ketorolac has been researched along with Vesico-Ureteral Reflux in 7 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Vesico-Ureteral Reflux: Retrograde flow of urine from the URINARY BLADDER into the URETER. This is often due to incompetence of the vesicoureteral valve leading to ascending bacterial infection into the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the efficacy of ketorolac in suppressing postoperative bladder spasms after ureteroneocystostomy (ureteral reimplantation)." | 9.09 | Ketorolac suppresses postoperative bladder spasms after pediatric ureteral reimplantation. ( Atala, A; Bauer, SB; Borer, JG; Cilento, BG; Diamond, DA; Houck, CS; Park, JM; Peters, CA; Retik, AB; Sethna, NF; Sullivan, LJ, 2000) |
| " All patients received ketorolac and acetaminophen with codeine for pain, and early in the series 7 patients received morphine." | 7.75 | Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes. ( Chamie, K; Chi, A; Hu, B; Keegan, KA; Kurzrock, EA, 2009) |
| "We evaluated the efficacy of ketorolac in suppressing postoperative bladder spasms after ureteroneocystostomy (ureteral reimplantation)." | 5.09 | Ketorolac suppresses postoperative bladder spasms after pediatric ureteral reimplantation. ( Atala, A; Bauer, SB; Borer, JG; Cilento, BG; Diamond, DA; Houck, CS; Park, JM; Peters, CA; Retik, AB; Sethna, NF; Sullivan, LJ, 2000) |
| " All patients received ketorolac and acetaminophen with codeine for pain, and early in the series 7 patients received morphine." | 3.75 | Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes. ( Chamie, K; Chi, A; Hu, B; Keegan, KA; Kurzrock, EA, 2009) |
| "Ketorolac was more effective in reducing the frequency of bladder spasms and rescue analgesic requirements." | 2.76 | Ketorolac or fentanyl continuous infusion for post-operative analgesia in children undergoing ureteroneocystostomy. ( Choi, EK; Hong, JY; Jo, YY; Kil, HK, 2011) |
| "Ketorolac use was associated with reduced length of stay (2 vs 3 days, P <." | 1.36 | Ketorolac is underutilized after ureteral reimplantation despite reduced hospital cost and reduced length of stay. ( Graham, DA; Nelson, CP; Routh, JC, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Palmer, JS | 2 |
| Chamie, K | 1 |
| Chi, A | 1 |
| Hu, B | 1 |
| Keegan, KA | 1 |
| Kurzrock, EA | 1 |
| Routh, JC | 1 |
| Graham, DA | 1 |
| Nelson, CP | 1 |
| Wiener, JS | 1 |
| Jo, YY | 1 |
| Hong, JY | 1 |
| Choi, EK | 1 |
| Kil, HK | 1 |
| Tripi, PA | 1 |
| Thomas, S | 1 |
| Elder, JS | 1 |
| Park, JM | 1 |
| Houck, CS | 1 |
| Sethna, NF | 1 |
| Sullivan, LJ | 1 |
| Atala, A | 1 |
| Borer, JG | 1 |
| Cilento, BG | 1 |
| Diamond, DA | 1 |
| Peters, CA | 1 |
| Retik, AB | 1 |
| Bauer, SB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oxybutynin for Post-surgical Bladder Pain and Urgency[NCT03952299] | Phase 3 | 100 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | ||
| Transversus Abdominis Plane Block Versus Caudal Epidural for Lower Abdominal Surgery in Children: A Double-Blinded Randomized Controlled Trial[NCT02160821] | Phase 4 | 45 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Prospective, Randomized, Double-Blinded, Allocation Concealed Study Comparing the Efficacy of Liposomal Bupivacaine Over Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Primary Total Knee Arthro[NCT02624856] | Phase 4 | 0 participants (Actual) | Interventional | 2015-11-30 | Withdrawn (stopped due to Lack of funding) | ||
| Comparison of Clonidine and Morphine Plus Bupivacaine in Caudal Peridural Anesthesia for Postoperative Analgesia After Pediatric Urogenital Surgery[NCT00672347] | Phase 1/Phase 2 | 80 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for ketorolac and Vesico-Ureteral Reflux
| Article | Year |
|---|---|
Ketorolac or fentanyl continuous infusion for post-operative analgesia in children undergoing ureteroneocystostomy.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Cystostomy; Double-Bl | 2011 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial.
Topics: Analgesics; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; | 2005 |
Ketorolac suppresses postoperative bladder spasms after pediatric ureteral reimplantation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Cystostomy; Double-Blind Method; H | 2000 |
4 other studies available for ketorolac and Vesico-Ureteral Reflux
| Article | Year |
|---|---|
Editorial comment.
Topics: Analgesics; Humans; Ketorolac; Minimally Invasive Surgical Procedures; Morphine; Pain Measurement; P | 2009 |
Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes.
Topics: Analgesics; Child, Preschool; Female; Humans; Ketorolac; Male; Minimally Invasive Surgical Procedure | 2009 |
Ketorolac is underutilized after ureteral reimplantation despite reduced hospital cost and reduced length of stay.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Drug Utilization; Fema | 2010 |
Editorial comment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Utilization; Humans; Ketorolac; Vesico-Ureteral | 2010 |