ketorolac has been researched along with Uveitis in 4 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the effect of topical ketorolac-tromethamine in the arachidonic acid metabolism on a model of endotoxin induced uveitis (EIU) in albino rabbits." | 7.70 | [Study of topical ketorolac effect on arachidonic acid metabolism in experimental anterior uveitis]. ( , 2000) |
| "To determine in rabbits whether periocular injection of ketorolac tromethamine effectively delivers the drug to the eye and, if so, whether this is efficacious in the treatment of experimental uveitis." | 7.69 | Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis. ( Fiscella, RG; Rabiah, PK; Tessler, HH, 1996) |
| "We studied the antiinflammatory effect of topical Ketorolac-Tromethamine on a model of endotoxin-induced uveitis in albino rabbits." | 3.70 | [Antiinflammatory capacity of topical ketorolac in experimental model of ocular inflammation]. ( Andrés, RC; Honrubia, FM; Júlvez, LP; Llorens, VP; Marín Del Tiempo, D; Moreno, OR; Novella, EF; Torrón, C, 2000) |
| "To determine in rabbits whether periocular injection of ketorolac tromethamine effectively delivers the drug to the eye and, if so, whether this is efficacious in the treatment of experimental uveitis." | 3.69 | Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis. ( Fiscella, RG; Rabiah, PK; Tessler, HH, 1996) |
| "Eyes treated with ketorolac and diclofenac demonstrated reduced aqueous leucocyte concentrations of 62% and 64% respectively, compared with untreated controls (p<0." | 1.35 | Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation. ( Barañano, DE; Durairaj, C; Edelhauser, HF; Handa, JT; Kim, SJ; Kompella, UB, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barañano, DE | 1 |
| Kim, SJ | 1 |
| Edelhauser, HF | 1 |
| Durairaj, C | 1 |
| Kompella, UB | 1 |
| Handa, JT | 1 |
| Rabiah, PK | 1 |
| Fiscella, RG | 1 |
| Tessler, HH | 1 |
| Moreno, OR | 1 |
| Andrés, RC | 1 |
| Júlvez, LP | 1 |
| Llorens, VP | 1 |
| Marín Del Tiempo, D | 1 |
| Novella, EF | 1 |
| Torrón, C | 1 |
| Honrubia, FM | 1 |
4 other studies available for ketorolac and Uveitis
| Article | Year |
|---|---|
Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; | 2009 |
Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Conjunctiva; Disease Models, Animal | 1996 |
[Antiinflammatory capacity of topical ketorolac in experimental model of ocular inflammation].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation, Preclinical; Female; Ketorolac; M | 2000 |
[Study of topical ketorolac effect on arachidonic acid metabolism in experimental anterior uveitis].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ketorol | 2000 |