ketorolac has been researched along with Ureteral Calculi in 4 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Ureteral Calculi: Stones in the URETER that are formed in the KIDNEY. They are rarely more than 5 mm in diameter for larger renal stones cannot enter ureters. They are often lodged at the ureteral narrowing and can cause excruciating renal colic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the safety and efficacy of xylocaine gel and ketorolac as opioid-sparing analgesia compared with pethidine for shock wave lithotripsy (SWL) pain." | 9.30 | Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial. ( Abol-Enein, H; Atwa, AM; El-Assmy, A; Elbaset, MA; Fadallah, M; Ghobrial, FK; Hashem, A; Laymon, M; Sheir, KZ, 2019) |
| "To compare the safety and efficacy of xylocaine gel and ketorolac as opioid-sparing analgesia compared with pethidine for shock wave lithotripsy (SWL) pain." | 5.30 | Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial. ( Abol-Enein, H; Atwa, AM; El-Assmy, A; Elbaset, MA; Fadallah, M; Ghobrial, FK; Hashem, A; Laymon, M; Sheir, KZ, 2019) |
| "Ketorolac was significantly (P < ." | 2.69 | Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic. ( Blair, GA; D'Amico, F; Larkin, GL; Peacock, WF; Pearl, SM, 1999) |
| "For ESWL treatment of kidney stones of 20 mm or less and ureteral stones of 15 mm or less, we suggest local analgesia with topical Luan and intramuscular analgesia." | 1.32 | ESWL: Comparing two analgesic techniques. Our experience. ( Aquilino, M; Bonaccorsi, A; Guzzardi, F; Lazzara, A; Motta, M; Saita, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashem, A | 1 |
| Ghobrial, FK | 1 |
| Elbaset, MA | 1 |
| Atwa, AM | 1 |
| Fadallah, M | 1 |
| Laymon, M | 1 |
| El-Assmy, A | 1 |
| Sheir, KZ | 1 |
| Abol-Enein, H | 1 |
| Saita, A | 1 |
| Bonaccorsi, A | 1 |
| Aquilino, M | 1 |
| Guzzardi, F | 1 |
| Lazzara, A | 1 |
| Motta, M | 1 |
| Larkin, GL | 1 |
| Peacock, WF | 1 |
| Pearl, SM | 1 |
| Blair, GA | 1 |
| D'Amico, F | 1 |
| Cooper, JT | 1 |
| Stack, GM | 1 |
| Cooper, TP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial Comparing the Combination of Intravenous Lidocaine and Ketorolac to Either Analgesics Alone for ED Patients With Acute Renal Colic[NCT02902770] | Phase 4 | 150 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The trial will compare the patient's pain score on a 11 point Likert scale, ranging from 0 to 10 with 0 being no pain, 5 moderate pain and 10 very severe pain, at 30 minutes (NCT02902770)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Lidocaine and Normal Saline Push | 5.52 |
| Ketorolac and Normal Saline Drip | 3.88 |
| Lidocaine and Ketorolac | 3.14 |
3 trials available for ketorolac and Ureteral Calculi
| Article | Year |
|---|---|
Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non- | 2019 |
Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; | 1999 |
Intensive medical management of ureteral calculi.
Topics: Absenteeism; Acetaminophen; Anti-Infective Agents, Urinary; Calcium Channel Blockers; Drug Therapy, | 2000 |
1 other study available for ketorolac and Ureteral Calculi
| Article | Year |
|---|---|
ESWL: Comparing two analgesic techniques. Our experience.
Topics: Administration, Topical; Adult; Aged; Analgesia; Betamethasone; Drug Therapy, Combination; Female; H | 2004 |