ketorolac has been researched along with Teeth, Impacted in 12 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale." | 3.01 | Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. ( Araújo, FA; Barros, AM; Lucena, EE; Martins-de-Barros, AV; Sette de Souza, PH; Siqueira, AK, 2021) |
| "The difference in postoperative pain was assessed by four primary points: pain intensity as measured by a 10 mm visual analogue scale hourly for 12 h, median time to rescue analgesics, number of analgesics consumed and patient's overall 5-point global assessment scale." | 2.79 | Comparative study of intravenous Tramadol versus Ketorolac for preventing postoperative pain after third molar surgery--a prospective randomized study. ( Gopalraju, P; Lalitha, RM; Prasad, K; Ranganath, K, 2014) |
| "Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated." | 2.77 | Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. ( Brozoski, DT; Calvo, AM; Colombini-Ishikiriama, BL; Dionísio, TJ; Faria, FA; Giglio, FP; Lauris, JR; Modena, KC; Ribeiro, DA; Santos, CF; Trindade, PA, 2012) |
| " Efficacy assessments included pain intensity, which was measured on a 0- to 100-mm visual analog scale, total pain relief, and global pain evaluation up to 8 hours after dosing or until patients required rescue analgesia." | 2.75 | Intranasal ketorolac for pain secondary to third molar impaction surgery: a randomized, double-blind, placebo-controlled trial. ( Grant, GM; Mehlisch, DR, 2010) |
| "The difference in postoperative pain was assessed by four primary end-points: pain intensity as measured by a 100-mm visual analogue scale hourly for 12 h, median time to rescue analgesic, postoperative acetaminophen consumption, and patient's global assessment." | 2.71 | Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery. ( Ong, KS; Tan, JM, 2004) |
| "The mean postoperative pain was measured for both groups." | 1.91 | Efficacy of Oral Toradol (Ketorolac) Compared to Oral Tramadol as a Preemptive Analgesic in Impacted Third Molar Surgery. ( Fazal, M; Rao, U, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Rao, U | 1 |
| Fazal, M | 1 |
| Martins-de-Barros, AV | 1 |
| Barros, AM | 1 |
| Siqueira, AK | 1 |
| Lucena, EE | 1 |
| Sette de Souza, PH | 1 |
| Araújo, FA | 1 |
| Gopalraju, P | 1 |
| Lalitha, RM | 1 |
| Prasad, K | 1 |
| Ranganath, K | 1 |
| Isiordia-Espinoza, MA | 3 |
| Pozos-Guillen, A | 1 |
| Martinez-Rider, R | 3 |
| Perez-Urizar, J | 3 |
| Grant, GM | 1 |
| Mehlisch, DR | 1 |
| Pozos-Guillén, AJ | 1 |
| Herrera-Abarca, JE | 1 |
| Sánchez-Prieto, M | 1 |
| Tobías-Azúa, F | 1 |
| Reyes-García, JG | 1 |
| Trindade, PA | 1 |
| Giglio, FP | 1 |
| Colombini-Ishikiriama, BL | 1 |
| Calvo, AM | 1 |
| Modena, KC | 1 |
| Ribeiro, DA | 1 |
| Dionísio, TJ | 1 |
| Brozoski, DT | 1 |
| Lauris, JR | 1 |
| Faria, FA | 1 |
| Santos, CF | 1 |
| Dionne, RA | 1 |
| Gordon, SM | 1 |
| Rowan, J | 1 |
| Kent, A | 1 |
| Brahim, JS | 1 |
| Ong, KS | 1 |
| Tan, JM | 1 |
| Pozos-Guillén, Ade J | 1 |
| Aguirre-Bañuelos, P | 1 |
| Arellano-Guerrero, A | 1 |
| Hoyo-Vadillo, C | 1 |
| Walton, GM | 1 |
| Rood, JP | 1 |
| Snowdon, AT | 1 |
| Rickwood, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preemptive Use of Etoricoxib and Dexamethasone: Effect on Early Bone Healing, Inflammatory Response, and Postoperative Parameters After Impacted Lower Third Molar Surgery[NCT05791721] | Phase 4 | 90 participants (Actual) | Interventional | 2021-10-11 | Completed | ||
| Evaluating Post-operative Pain Management Efficacy of Intra Nasal Ketorolac in Ambulatory Urological Surgeries-A Randomized Double-blinded Placebo Controlled Study[NCT01736358] | Phase 4 | 50 participants (Actual) | Interventional | 2012-10-31 | Terminated (stopped due to Interim analysis showed futility of primary endpoint) | ||
| Efficacy of the Combination Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: a Randomized Clinical Trial.[NCT02110966] | Phase 4 | 56 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To find the incidence of immediate (until discharge) and 24hrs post operative side effects in the target population. (NCT01736358)
Timeframe: 24 hours after procedure
| Intervention | number of events (Number) |
|---|---|
| Intranasal Ketoralac | 0 |
| Placebo | 0 |
To evaluate the post operative pain score using the Visual Analog Scale (VAS) 2 hours after surgery. The scale for VAS is 0 is no pain to 10 being the worst pain. (NCT01736358)
Timeframe: 2 hours after surgery
| Intervention | score on a scale (Median) |
|---|---|
| Intranasal Ketoralac | 4 |
| Placebo | 3 |
To evaluate the post operative pain score using the Visual Analog Scale (VAS) 1 hour after surgery. The scale for VAS is 0 is no pain to 10 being the worst pain. (NCT01736358)
Timeframe: 1 hour after surgery
| Intervention | score on a scale (Median) |
|---|---|
| Intranasal Ketoralac | 3.5 |
| Placebo | 4.5 |
To evaluate the post operative pain score using the Visual Analog Scale (VAS) 30 minutes after surgery. The scale for VAS is 0 is no pain to 10 being the worst pain. (NCT01736358)
Timeframe: 30 minutes after surgery
| Intervention | score on a scale (Median) |
|---|---|
| Intranasal Ketoralac | 4 |
| Placebo | 3.5 |
this study will assess the effect of perioperative usage of single-dose of intranasal ketorolac on post operative opioid requirements within 3 hours after surgery. (NCT01736358)
Timeframe: 3 hours after surgery
| Intervention | mg (Median) |
|---|---|
| Intranasal Ketoralac | 27.43 |
| Placebo | 30 |
11 trials available for ketorolac and Teeth, Impacted
| Article | Year |
|---|---|
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial.
Topics: Dexamethasone; Double-Blind Method; Edema; Female; Humans; Ketorolac; Male; Molar, Third; Pain, Post | 2021 |
Comparative study of intravenous Tramadol versus Ketorolac for preventing postoperative pain after third molar surgery--a prospective randomized study.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Ag | 2014 |
Comparison of the analgesic efficacy of oral ketorolac versus intramuscular tramadol after third molar surgery: A parallel, double-blind, randomized, placebo-controlled clinical trial.
Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans | 2016 |
Intranasal ketorolac for pain secondary to third molar impaction surgery: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Intranasal; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhi | 2010 |
Preemptive analgesic effectiveness of oral ketorolac plus local tramadol after impacted mandibular third molar surgery.
Topics: Administration, Oral; Administration, Topical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2011 |
Preemptive analgesic effectiveness of oral ketorolac plus local tramadol after impacted mandibular third molar surgery.
Topics: Administration, Oral; Administration, Topical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2011 |
Preemptive analgesic effectiveness of oral ketorolac plus local tramadol after impacted mandibular third molar surgery.
Topics: Administration, Oral; Administration, Topical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2011 |
Preemptive analgesic effectiveness of oral ketorolac plus local tramadol after impacted mandibular third molar surgery.
Topics: Administration, Oral; Administration, Topical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2011 |
Pre-emptive analgesic effectiveness of meloxicam versus tramadol after mandibular third molar surgery: a pilot study.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; | 2012 |
Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal.
Topics: Analysis of Variance; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Edema; Fem | 2012 |
Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation.
Topics: Adult; Analgesia; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Dino | 2003 |
Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-Inflamm | 2004 |
Analgesic efficacy of tramadol by route of administration in a clinical model of pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2005 |
Ketorolac and diclofenac for postoperative pain relief following oral surgery.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, | 1993 |
1 other study available for ketorolac and Teeth, Impacted
| Article | Year |
|---|---|
Efficacy of Oral Toradol (Ketorolac) Compared to Oral Tramadol as a Preemptive Analgesic in Impacted Third Molar Surgery.
Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans | 2023 |