Page last updated: 2024-10-29

ketorolac and Strabismus

ketorolac has been researched along with Strabismus in 9 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Strabismus: Misalignment of the visual axes of the eyes. In comitant strabismus the degree of ocular misalignment does not vary with the direction of gaze. In noncomitant strabismus the degree of misalignment varies depending on direction of gaze or which eye is fixating on the target. (Miller, Walsh & Hoyt's Clinical Neuro-Ophthalmology, 4th ed, p641)

Research Excerpts

ExcerptRelevanceReference
"To determine the efficacy of preoperative intravenous ketorolac in reducing intraoperative and postoperative pain and improving patient satisfaction in patients undergoing single-stage adjustable strabismus surgery."9.15The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial. ( Bae, SJ; Chang, JH; Chung, SA; Kim, WK; Lee, JB; Rhiu, S, 2011)
"5% ketorolac eye drops at the start and end of strabismus repair surgery."9.10Amethocaine or ketorolac eyedrops provide inadequate analgesia in pediatric strabismus surgery. ( Azavedo, L; Bhananker, S; Bonn, G; Kim, J; Splinter, W, 2003)
"To determine the efficacy of oral granisetron in preventing postoperative vomiting (POV) following strabismus repair in children."9.09Oral granisetron for strabismus surgery in children. ( D'Errico, CC; Lauder, GR; Munro, HM; Tait, AR; Voepel-Lewis, T; Wagner, DS, 1999)
"Fifty-four ASA I and II children 1 to 10 yr of age undergoing strabismus surgery were randomized to receive in a double-blind fashion intravenous ketorolac (0."9.08The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery. ( Guarnieri, KM; Mendel, HG; Sundt, LM; Torjman, MC, 1995)
" ketorolac and morphine in paediatric outpatients undergoing strabismus surgery."9.07Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Riegger, LQ; Wilton, NC, 1994)
" The authors compare the effectiveness of a single intravenous dose of ketorolac with a single oral dose of either acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus."9.07Ketorolac versus acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus. ( Morrison, NA; Repka, MX, 1994)
"To determine the efficacy of preoperative intravenous ketorolac in reducing intraoperative and postoperative pain and improving patient satisfaction in patients undergoing single-stage adjustable strabismus surgery."5.15The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial. ( Bae, SJ; Chang, JH; Chung, SA; Kim, WK; Lee, JB; Rhiu, S, 2011)
"5% ketorolac eye drops at the start and end of strabismus repair surgery."5.10Amethocaine or ketorolac eyedrops provide inadequate analgesia in pediatric strabismus surgery. ( Azavedo, L; Bhananker, S; Bonn, G; Kim, J; Splinter, W, 2003)
"To determine the efficacy of oral granisetron in preventing postoperative vomiting (POV) following strabismus repair in children."5.09Oral granisetron for strabismus surgery in children. ( D'Errico, CC; Lauder, GR; Munro, HM; Tait, AR; Voepel-Lewis, T; Wagner, DS, 1999)
"Fifty-four ASA I and II children 1 to 10 yr of age undergoing strabismus surgery were randomized to receive in a double-blind fashion intravenous ketorolac (0."5.08The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery. ( Guarnieri, KM; Mendel, HG; Sundt, LM; Torjman, MC, 1995)
" ketorolac and morphine in paediatric outpatients undergoing strabismus surgery."5.07Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Riegger, LQ; Wilton, NC, 1994)
" The authors compare the effectiveness of a single intravenous dose of ketorolac with a single oral dose of either acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus."5.07Ketorolac versus acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus. ( Morrison, NA; Repka, MX, 1994)
"Postoperative pain is a significant cause of morbidity in pediatric anesthesia, which can result in delayed discharge and unplanned hospital admission."1.56Reducing postoperative pain in children undergoing strabismus surgery: From bundle implementation to clinical decision support tools. ( Ali, U; Balakrishnan, S; Campbell, F; Igbeyi, B; Kotzer, G; Matava, C; Mc Donnell, C; Shackell, K; Tsang, M, 2020)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Ali, U1
Tsang, M1
Campbell, F1
Matava, C1
Igbeyi, B1
Balakrishnan, S1
Shackell, K1
Kotzer, G1
Mc Donnell, C1
Rhiu, S1
Chung, SA1
Kim, WK1
Chang, JH1
Bae, SJ1
Lee, JB1
Kim, J1
Azavedo, L1
Bhananker, S1
Bonn, G1
Splinter, W1
Mendel, HG1
Guarnieri, KM1
Sundt, LM1
Torjman, MC1
Munro, HM3
Riegger, LQ2
Reynolds, PI2
Wilton, NC1
Lewis, IH1
Morrison, NA1
Repka, MX1
D'Errico, CC1
Lauder, GR1
Wagner, DS1
Voepel-Lewis, T1
Tait, AR1
Bridge, HS1
Montgomery, CJ1
Kennedy, RA1
Merrick, PM1

Trials

7 trials available for ketorolac and Strabismus

ArticleYear
The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial.
    Eye (London, England), 2011, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Analgesia; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cycloox

2011
Amethocaine or ketorolac eyedrops provide inadequate analgesia in pediatric strabismus surgery.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Anesthesia, Local; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Presch

2003
The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery.
    Anesthesia and analgesia, 1995, Volume: 80, Issue:6

    Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia; Child; Child, P

1995
Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery.
    British journal of anaesthesia, 1994, Volume: 72, Issue:6

    Topics: Ambulatory Surgical Procedures; Analgesics; Child; Child, Preschool; Double-Blind Method; Female; Hu

1994
Ketorolac versus acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus.
    Ophthalmology, 1994, Volume: 101, Issue:5

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory A

1994
Oral granisetron for strabismus surgery in children.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1999, Volume: 46, Issue:1

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Antiemetics;

1999
Analgesic efficacy of ketorolac 0.5% ophthalmic solution (Accular) in paediatric strabismus surgery.
    Paediatric anaesthesia, 2000, Volume: 10, Issue:5

    Topics: Child; Child, Preschool; Double-Blind Method; Female; Humans; Ketorolac; Male; Ophthalmic Solutions;

2000

Other Studies

2 other studies available for ketorolac and Strabismus

ArticleYear
Reducing postoperative pain in children undergoing strabismus surgery: From bundle implementation to clinical decision support tools.
    Paediatric anaesthesia, 2020, Volume: 30, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child

2020
Ketorolac and strabismus surgery.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:4

    Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Postoperative Complications; Strabismus; Tolmetin; Vomi

1996