ketorolac has been researched along with Sensitivity and Specificity in 10 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parecoxib sodium was safe and well tolerated." | 2.70 | Intravenous parecoxib sodium foracute pain after orthopedic knee surgery. ( Hogue, C; Hubbard, RC; Rasmussen, GL; Steckner, K; Torri, S, 2002) |
| " Further, the method was also successfully applied to a single-dose pharmacokinetic study in rats." | 1.38 | Development and validation of liquid chromatography-mass spectrometric method for simultaneous determination of moxifloxacin and ketorolac in rat plasma: application to pharmacokinetic study. ( Banerjee, SK; Borkar, RM; Padiya, R; Raju, B; Ramesh, M; Srinivas, R, 2012) |
| "Ketorolac is an analgesic drug known to induce its therapeutic effect by inhibiting prostaglandin synthesis." | 1.29 | Ionophoretic-like properties of ketorolac for calcium. ( Bravo, C; Chàvez, E; Chàvez, R; Corona, N; González, C; Pichardo, J; Reyes-Vivas, H; Uribe, A; Zazueta, C, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, L | 1 |
| Guarino, BB | 1 |
| Jordan-Sciutto, KL | 1 |
| Winkelstein, BA | 1 |
| Raju, B | 1 |
| Ramesh, M | 1 |
| Borkar, RM | 1 |
| Padiya, R | 1 |
| Banerjee, SK | 1 |
| Srinivas, R | 1 |
| Orlandini, S | 1 |
| Furlanetto, S | 1 |
| Pinzauti, S | 1 |
| D'Orazio, G | 1 |
| Fanali, S | 1 |
| White, A | 1 |
| Bigby, T | 1 |
| Stevenson, D | 1 |
| Chàvez, R | 1 |
| Bravo, C | 1 |
| Zazueta, C | 1 |
| Pichardo, J | 1 |
| Uribe, A | 1 |
| Corona, N | 1 |
| Reyes-Vivas, H | 1 |
| González, C | 1 |
| Chàvez, E | 1 |
| Liu, H | 1 |
| Wehmeyer, KR | 1 |
| Mills, MH | 1 |
| Mather, LE | 1 |
| Gu, XS | 1 |
| Huang, JL | 1 |
| Laifer, SA | 1 |
| Rauk, PN | 1 |
| Tsina, I | 1 |
| Tam, YL | 1 |
| Boyd, A | 1 |
| Rocha, C | 1 |
| Massey, I | 1 |
| Tarnowski, T | 1 |
| Rasmussen, GL | 1 |
| Steckner, K | 1 |
| Hogue, C | 1 |
| Torri, S | 1 |
| Hubbard, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study to Evaluate Efficacy and Safety of Postoperative Intravenous Parecoxib Sodium Followed by Oral Celecoxib Post Total Knee Arthroplasty in Osteoarthritis Patients[NCT02198924] | Phase 4 | 246 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for ketorolac and Sensitivity and Specificity
| Article | Year |
|---|---|
Intranasal ketorolac challenge for the diagnosis of aspirin-exacerbated respiratory disease.
Topics: Administration, Intranasal; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Dr | 2006 |
Intravenous parecoxib sodium foracute pain after orthopedic knee surgery.
Topics: Aged; Analgesia; Arthroplasty, Replacement, Knee; Dose-Response Relationship, Drug; Double-Blind Met | 2002 |
8 other studies available for ketorolac and Sensitivity and Specificity
| Article | Year |
|---|---|
Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction.
Topics: Activating Transcription Factor 4; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Ster | 2011 |
Development and validation of liquid chromatography-mass spectrometric method for simultaneous determination of moxifloxacin and ketorolac in rat plasma: application to pharmacokinetic study.
Topics: Animals; Aza Compounds; Chromatography, High Pressure Liquid; Drug Stability; Fluoroquinolones; Keto | 2012 |
Analysis of ketorolac and its related impurities by capillary electrochromatography.
Topics: Calibration; Chromatography, Micellar Electrokinetic Capillary; Ketorolac; Reproducibility of Result | 2004 |
Ionophoretic-like properties of ketorolac for calcium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Calcium; Hydrogen-Ion Concen | 1993 |
Supercritical fluid extraction as a sample preparation technique for the direct isolation of drugs from plasma prior to analysis.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Chemical Phenomena; Chemistry, Physical; Chromatograp | 1994 |
Determination of ketorolac enantiomers in plasma using enantioselective liquid chromatography on an alpha 1-acid glycoprotein chiral stationary phase and ultraviolet detection.
Topics: Chromatography, High Pressure Liquid; Humans; Ketorolac; Kinetics; Orosomucoid; Sensitivity and Spec | 1994 |
Ritodrine increases leukotriene B4 concentrations in pregnant sheep.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arteries; Female; Infusions, Intravenous; Ketorola | 1993 |
An indirect (derivatization) and a direct HPLC method for the determination of the enantiomers of ketorolac in plasma.
Topics: Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Drug Stability; Evaluation Studies a | 1996 |