ketorolac has been researched along with Rib Fractures in 2 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Rib Fractures: Fractures of any of the RIBS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A retrospective cohort study was conducted spanning January 2003 to June 2011 assessing pneumonia within 30 days and potential adverse effects of ketorolac among all patients with rib fractures who received ketorolac <4 days after injury compared with a random sample of those who did not." | 9.19 | Use of ketorolac is associated with decreased pneumonia following rib fractures. ( Schermer, CR; Utter, GH; Yang, Y; Young, JB, 2014) |
| "Ketorolac is useful in acute pain management to avoid opiate-related complications; however, some surgeons fear associated acute kidney injury (AKI) and bleeding despite a paucity of literature on ketorolac use in trauma patients." | 8.02 | Ketorolac Use for Pain Management in Trauma Patients With Rib Fractures Does not Increase of Acute Kidney Injury or Incidence of Bleeding. ( Chao, E; DeHaan, S; Jureller, M; Kaban, JM; Laikhram, D; Lewis, E; Reddy, SH; Simon, R; Stone, ME; Torabi, J, 2021) |
| "A retrospective cohort study was conducted spanning January 2003 to June 2011 assessing pneumonia within 30 days and potential adverse effects of ketorolac among all patients with rib fractures who received ketorolac <4 days after injury compared with a random sample of those who did not." | 5.19 | Use of ketorolac is associated with decreased pneumonia following rib fractures. ( Schermer, CR; Utter, GH; Yang, Y; Young, JB, 2014) |
| "Ketorolac is useful in acute pain management to avoid opiate-related complications; however, some surgeons fear associated acute kidney injury (AKI) and bleeding despite a paucity of literature on ketorolac use in trauma patients." | 4.02 | Ketorolac Use for Pain Management in Trauma Patients With Rib Fractures Does not Increase of Acute Kidney Injury or Incidence of Bleeding. ( Chao, E; DeHaan, S; Jureller, M; Kaban, JM; Laikhram, D; Lewis, E; Reddy, SH; Simon, R; Stone, ME; Torabi, J, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Torabi, J | 1 |
| Kaban, JM | 1 |
| Lewis, E | 1 |
| Laikhram, D | 1 |
| Simon, R | 1 |
| DeHaan, S | 1 |
| Jureller, M | 1 |
| Chao, E | 1 |
| Reddy, SH | 1 |
| Stone, ME | 1 |
| Yang, Y | 1 |
| Young, JB | 1 |
| Schermer, CR | 1 |
| Utter, GH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Serratus Plane Block With Parenteral Opioid Analgesia Versus Patient Controlled Analgesia Alone in Acute Rib fracturEs[NCT03919916] | 58 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ketorolac and Rib Fractures
| Article | Year |
|---|---|
Use of ketorolac is associated with decreased pneumonia following rib fractures.
Topics: Anti-Inflammatory Agents, Non-Steroidal; California; Confidence Intervals; Dose-Response Relationshi | 2014 |
1 other study available for ketorolac and Rib Fractures
| Article | Year |
|---|---|
Ketorolac Use for Pain Management in Trauma Patients With Rib Fractures Does not Increase of Acute Kidney Injury or Incidence of Bleeding.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Stero | 2021 |