Page last updated: 2024-10-29
ketorolac and Reproductive Sterility
ketorolac has been researched along with Reproductive Sterility in 1 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "To study the effect of ketorolac, a potent anti-inflammatory medication, on in vitro fertilization (IVF) pregnancy outcomes when used at the time of oocyte retrieval." | 7.79 | The effect of ketorolac on pregnancy rates when used immediately after oocyte retrieval. ( Hurst, BS; Kacemi-Bourhim, L; Marshburn, PB; Matthews, M; Mesen, TB; Norton, HJ; Usadi, RS, 2013) |
| "To study the effect of ketorolac, a potent anti-inflammatory medication, on in vitro fertilization (IVF) pregnancy outcomes when used at the time of oocyte retrieval." | 3.79 | The effect of ketorolac on pregnancy rates when used immediately after oocyte retrieval. ( Hurst, BS; Kacemi-Bourhim, L; Marshburn, PB; Matthews, M; Mesen, TB; Norton, HJ; Usadi, RS, 2013) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Mesen, TB | 1 |
| Kacemi-Bourhim, L | 1 |
| Marshburn, PB | 1 |
| Usadi, RS | 1 |
| Matthews, M | 1 |
| Norton, HJ | 1 |
| Hurst, BS | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| A Randomized Blinded Placebo Controlled Trial Assessing Ketorolac (Toradol) at Oocyte Retrieval[NCT06026553] | Phase 1 | 400 participants (Anticipated) | Interventional | 2022-08-10 | Recruiting |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Other Studies
1 other study available for ketorolac and Reproductive Sterility