ketorolac has been researched along with Renal Insufficiency in 8 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This case report describes postoperative, reversible renal dysfunction and hypertension in a 5-year-old healthy boy after administration of relevant doses of ketorolac during anaesthesia." | 3.75 | [Ketorolac as a possible cause of reversible renal dysfunction in a 5-year-old child]. ( Knudsen, SM; Mantoni, T; Walther-Larsen, S, 2009) |
| "No cases of post-operative renal failure requiring dialysis were described." | 2.41 | Effects of nonsteroidal anti-inflammatory drugs on post-operative renal function in adults. ( Cooper, MG; Craig, JC; Keneally, JP; Knight, JF; Lee, A, 2000) |
| "Ketorolac was given to 167 patients intraoperatively or postoperatively within 24 h after LDN." | 1.46 | Perioperative Ketorolac Use: A Potential Risk Factor for Renal Dysfunction After Live-Donor Nephrectomy. ( Denny, JE; Kane, WJ; Kim, DY; Malinzak, LE; Nagai, S; Patel, AK; Putchakayala, KG; Safwan, M; Takahashi, K; Yoshida, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takahashi, K | 1 |
| Patel, AK | 1 |
| Nagai, S | 1 |
| Safwan, M | 1 |
| Putchakayala, KG | 1 |
| Kane, WJ | 1 |
| Malinzak, LE | 1 |
| Denny, JE | 1 |
| Yoshida, A | 1 |
| Kim, DY | 1 |
| Tabrizian, P | 1 |
| Giacca, M | 1 |
| Prigoff, J | 1 |
| Tran, B | 1 |
| Holzner, ML | 1 |
| Chin, E | 1 |
| Palese, M | 1 |
| Herron, D | 1 |
| Arvelakis, A | 1 |
| Rudow, DL | 1 |
| Florman, S | 1 |
| Shapiro, R | 1 |
| Knudsen, SM | 1 |
| Mantoni, T | 1 |
| Walther-Larsen, S | 1 |
| Iudin, MA | 1 |
| Kurpiakova, AF | 1 |
| Bykov, VN | 1 |
| Chepur, SV | 1 |
| Nikiforov, AS | 1 |
| Selbst, SM | 1 |
| Devavaram, P | 1 |
| Simckes, AM | 1 |
| Chen, SS | 1 |
| Osorio, AV | 1 |
| Garola, RE | 1 |
| Woods, GM | 1 |
| Lee, A | 1 |
| Cooper, MG | 1 |
| Craig, JC | 1 |
| Knight, JF | 1 |
| Keneally, JP | 1 |
1 review available for ketorolac and Renal Insufficiency
| Article | Year |
|---|---|
Effects of nonsteroidal anti-inflammatory drugs on post-operative renal function in adults.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Diclofenac; Humans; Ketorolac; Kidney; P | 2000 |
7 other studies available for ketorolac and Renal Insufficiency
| Article | Year |
|---|---|
Perioperative Ketorolac Use: A Potential Risk Factor for Renal Dysfunction After Live-Donor Nephrectomy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Glomerular Filtration Rate; Humans; Ketorola | 2017 |
Renal Safety of Intravenous Ketorolac Use After Donor Nephrectomy.
Topics: Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Female; Hum | 2019 |
[Ketorolac as a possible cause of reversible renal dysfunction in a 5-year-old child].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Hernia, Umbilical; Humans; Hypertension; | 2009 |
[Studying toxicity caused by interaction of caffeine and ketorolac].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Incompatibility; Drug Interactions; | 2012 |
Pediatric emergency medicine: legal briefs.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Diagnostic Errors; Emergency Medicine; Humans; | 2012 |
Ketorolac and renal compromise in neonates.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Infant, Newborn; Ketorolac; Pain, Postoperative; Re | 2007 |
Ketorolac-induced irreversible renal failure in sickle cell disease: a case report.
Topics: Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; | 1999 |