ketorolac has been researched along with Pyrexia in 7 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this preliminary study was to compare acetaminophen to ketorolac for treating patients with fever in the emergency department (ED)." | 9.09 | Ketorolac versus acetaminophen for treatment of acute fever in the emergency department. ( Ernst, A; Houry, D; Ledbetter, M; Weiss, S, 1999) |
| "The authors studied the antipyretic effect of three intramuscular doses of ketorolac (15, 30, and 60 mg), acetaminophen 650 mg PO, and placebo in healthy male volunteers using an endotoxin-induced fever model." | 9.07 | Evaluation of the antipyretic effect of ketorolac, acetaminophen, and placebo in endotoxin-induced fever. ( Bynum, L; Maneatis, T; McMahon, FG; Peterson, C; Vargas, R, 1994) |
| "The purpose of this preliminary study was to compare acetaminophen to ketorolac for treating patients with fever in the emergency department (ED)." | 5.09 | Ketorolac versus acetaminophen for treatment of acute fever in the emergency department. ( Ernst, A; Houry, D; Ledbetter, M; Weiss, S, 1999) |
| "The authors studied the antipyretic effect of three intramuscular doses of ketorolac (15, 30, and 60 mg), acetaminophen 650 mg PO, and placebo in healthy male volunteers using an endotoxin-induced fever model." | 5.07 | Evaluation of the antipyretic effect of ketorolac, acetaminophen, and placebo in endotoxin-induced fever. ( Bynum, L; Maneatis, T; McMahon, FG; Peterson, C; Vargas, R, 1994) |
| ") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)." | 3.72 | Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004) |
| "Treatment with ketorolac after abdominal myomectomy results in a statistically significant reduction in the rate of febrile episodes." | 2.70 | The effect of ketorolac on postoperative febrile episodes in patients after abdominal myomectomy. ( Ascher-Walsh, C; Blanco, J; Held, BI; Michels, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, N | 1 |
| McGinn, R | 1 |
| Stapleton, JM | 1 |
| Paull, G | 1 |
| Meade, RD | 1 |
| Kenny, GP | 1 |
| Held, BI | 1 |
| Michels, A | 1 |
| Blanco, J | 1 |
| Ascher-Walsh, C | 1 |
| Padi, SS | 1 |
| Jain, NK | 1 |
| Singh, S | 1 |
| Kulkarni, SK | 1 |
| Vargas, R | 1 |
| Maneatis, T | 1 |
| Bynum, L | 1 |
| Peterson, C | 1 |
| McMahon, FG | 1 |
| Scammell, TE | 1 |
| Griffin, JD | 1 |
| Elmquist, JK | 1 |
| Saper, CB | 1 |
| Houry, D | 1 |
| Ernst, A | 1 |
| Weiss, S | 1 |
| Ledbetter, M | 1 |
| Gerhardt, RT | 1 |
| Gerhardt, DM | 1 |
3 trials available for ketorolac and Pyrexia
| Article | Year |
|---|---|
The effect of ketorolac on postoperative febrile episodes in patients after abdominal myomectomy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Fever; Gynecologic Surg | 2002 |
Evaluation of the antipyretic effect of ketorolac, acetaminophen, and placebo in endotoxin-induced fever.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 1994 |
Ketorolac versus acetaminophen for treatment of acute fever in the emergency department.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Body Temperature; Doub | 1999 |
4 other studies available for ketorolac and Pyrexia
| Article | Year |
|---|---|
Evidence for cyclooxygenase-dependent sweating in young males during intermittent exercise in the heat.
Topics: Adult; Body Temperature Regulation; Cyclooxygenase Inhibitors; Exercise; Fever; Heat Stress Disorder | 2014 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever.
Topics: Analgesics, Non-Narcotic; Animals; Brain Mapping; Cyclooxygenase Inhibitors; Fever; Ketorolac; Lipop | 1998 |
Intravenous ketorolac in the treatment of fever.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Fever; Humans; Infusions, Intravenous | 2000 |