ketorolac has been researched along with Pruritus in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Secondary measures were morphine usage in the first 8 and 24h postoperatively, numeric rating scores (NRS) up to 24h, sedation, nausea, vomiting, respiratory depression, pruritus and bleeding complications." | 5.24 | Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial. ( Davis, M; De Guzman, C; Duttchen, KM; Lo, A; McLuckie, D; Roman-Smith, H; Walker, A, 2017) |
| "The therapeutic utility of cyclooxygenase (CO) inhibitors, such as ketorolac, in reducing the inflammatory events associated with allergic conjunctivitis is not unexpected since prostanoids (PG) elicit conjunctival redness (PGD2, PGE2, PGF2 alpha), edema (PGD2, TxA2), eosinophil infiltration (PGD2, PGJ2) and mucous cell discharge (PGD2, PGJ2, TxA2)." | 3.69 | The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. ( Hawley, SB; Joseph, R; Merlino, GF; Nieves, AL; Spada, CS; Woodward, DF, 1995) |
| "Topically administered ketorolac (Acular), a cyclooxygenase inhibitor, has recently been reported as clinically beneficial for treating allergic conjunctivitis." | 3.69 | Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching. ( Friedlaender, MH; Nieves, AL; Woodward, DF, 1996) |
| "Postoperative pain was managed with patient-controlled analgesia using ketorolac." | 2.78 | Is pain after TKA better with periarticular injection or intrathecal morphine? ( Kanitnate, S; Manuwong, S; Panichkul, P; Tammachote, N; Yakumpor, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duttchen, KM | 1 |
| Lo, A | 1 |
| Walker, A | 1 |
| McLuckie, D | 1 |
| De Guzman, C | 1 |
| Roman-Smith, H | 1 |
| Davis, M | 1 |
| Singh, SI | 1 |
| Rehou, S | 1 |
| Marmai, KL | 1 |
| Jones, APM | 1 |
| Tammachote, N | 1 |
| Kanitnate, S | 1 |
| Manuwong, S | 1 |
| Yakumpor, T | 1 |
| Panichkul, P | 1 |
| Woodward, DF | 2 |
| Nieves, AL | 2 |
| Hawley, SB | 1 |
| Joseph, R | 1 |
| Merlino, GF | 1 |
| Spada, CS | 1 |
| Friedlaender, MH | 1 |
| Reinhart, DJ | 1 |
| Goldberg, ME | 1 |
| Roth, JV | 1 |
| Dua, R | 1 |
| Nevo, I | 1 |
| Klein, KW | 1 |
| Torjman, M | 1 |
| Vekeman, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Low-dose Epidural Morphine Combined With Single-injection Femoral Nerve Block on Postoperative Analgesia in Patients After Total Knee Arthroplasty[NCT03203967] | 110 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery[NCT02487303] | 148 participants (Actual) | Interventional | 2015-03-17 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cumulative opiate consumption (IV morphine equivalents) (NCT02487303)
Timeframe: 24 hours
| Intervention | mg (Mean) |
|---|---|
| Acetaminophen Intravenous | 2.9 |
| Acetaminophen Oral | 3.8 |
| No Acetaminophen | 5.7 |
Time patient meets discharge criteria will be recorded (NCT02487303)
Timeframe: 24 hours postoperative
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 48.4 |
| Acetaminophen Oral | 48.6 |
| No Acetaminophen | 50.5 |
Time to first opiate pain medicine requested by patient (NCT02487303)
Timeframe: 48 hours
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 25.3 |
| Acetaminophen Oral | 24.0 |
| No Acetaminophen | 21.3 |
"Visual Analog Scale (VAS) pain assessment with ambulation. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain and worst pain. For pain intensity, the scale is most commonly anchored by no pain (score of 0) and pain as bad as it could be or worst imaginable pain (score of 100 [100-mm scale]) ." (NCT02487303)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Acetaminophen Intravenous | 37.8 |
| Acetaminophen Oral | 44.3 |
| No Acetaminophen | 50.8 |
4 trials available for ketorolac and Pruritus
| Article | Year |
|---|---|
Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial.
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double | 2017 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
Is pain after TKA better with periarticular injection or intrathecal morphine?
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Antipruritics; Arthr | 2013 |
Transdermal fentanyl system plus im ketorolac for the treatment of postoperative pain.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 1997 |
2 other studies available for ketorolac and Pruritus
| Article | Year |
|---|---|
The pruritogenic and inflammatory effects of prostanoids in the conjunctiva.
Topics: Animals; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Cyclooxygenase Inhibitors; D | 1995 |
Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching.
Topics: Animals; Conjunctivitis, Allergic; Female; Guinea Pigs; Ketorolac; Male; Prostaglandins; Pruritus; R | 1996 |