ketorolac has been researched along with Pericementitis in 2 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The selective COX-2 inhibitors hold promise for clinical efficacy with less toxicity from chronic administration and may prove advantageous for the relief of chronic orofacial pain." | 2.41 | Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry. ( Berthold, CW; Dionne, RA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luan, Q | 1 |
| Desta, T | 1 |
| Chehab, L | 1 |
| Sanders, VJ | 1 |
| Plattner, J | 1 |
| Graves, DT | 1 |
| Dionne, RA | 1 |
| Berthold, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preliminary Studies for Whole Genome Association Study (WGAS) in Acute Perioperative Pain[NCT01557751] | 156 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The primary endpoint is the pain reported by subjects, using the NRS-Pain with movement on the second day after surgery.The assumption behind this study is that certain genetic variants (e.g. single-nucleotide polymorphism (SNP) are responsible for part of total variation of certain clinical phenotypes (e.g. post-operative pain here).~Numeric Rating Score Pain Assessment (0-10 scale where 0 indicates no pain at all and 10 indicates the worst pain imaginable) on Post Op Day 2, Pain with Movement" (NCT01557751)
Timeframe: Postoperative day (POD) 2
| Intervention | units on a scale (Mean) |
|---|---|
| Total Knee Arthroplasty Subjects Who Are Genotyped | 2.83 |
1 review available for ketorolac and Pericementitis
| Article | Year |
|---|---|
Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; beta-Endorphin; Cyclooxygenase 2; Cyclo | 2001 |
1 other study available for ketorolac and Pericementitis
| Article | Year |
|---|---|
Inhibition of experimental periodontitis by a topical boron-based antimicrobial.
Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Anti-Inflammatory | 2008 |