ketorolac has been researched along with Pain, Breakthrough in 2 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wilson, SH | 1 |
| Wolf, BJ | 1 |
| Robinson, SM | 1 |
| Nelson, C | 1 |
| Hebbar, L | 1 |
| De Franceschi, L | 1 |
| Mura, P | 1 |
| Schweiger, V | 1 |
| Vencato, E | 1 |
| Quaglia, FM | 1 |
| Delmonte, L | 1 |
| Evangelista, M | 1 |
| Polati, E | 1 |
| Olivieri, O | 1 |
| Finco, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery[NCT02487303] | 148 participants (Actual) | Interventional | 2015-03-17 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cumulative opiate consumption (IV morphine equivalents) (NCT02487303)
Timeframe: 24 hours
| Intervention | mg (Mean) |
|---|---|
| Acetaminophen Intravenous | 2.9 |
| Acetaminophen Oral | 3.8 |
| No Acetaminophen | 5.7 |
Time patient meets discharge criteria will be recorded (NCT02487303)
Timeframe: 24 hours postoperative
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 48.4 |
| Acetaminophen Oral | 48.6 |
| No Acetaminophen | 50.5 |
Time to first opiate pain medicine requested by patient (NCT02487303)
Timeframe: 48 hours
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 25.3 |
| Acetaminophen Oral | 24.0 |
| No Acetaminophen | 21.3 |
"Visual Analog Scale (VAS) pain assessment with ambulation. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain and worst pain. For pain intensity, the scale is most commonly anchored by no pain (score of 0) and pain as bad as it could be or worst imaginable pain (score of 100 [100-mm scale]) ." (NCT02487303)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Acetaminophen Intravenous | 37.8 |
| Acetaminophen Oral | 44.3 |
| No Acetaminophen | 50.8 |
1 trial available for ketorolac and Pain, Breakthrough
| Article | Year |
|---|---|
Intravenous vs Oral Acetaminophen for Analgesia After Cesarean Delivery: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Analgesics, Non-Narcotic; A | 2019 |
1 other study available for ketorolac and Pain, Breakthrough
| Article | Year |
|---|---|
Fentanyl Buccal Tablet: A New Breakthrough Pain Medication in Early Management of Severe Vaso-Occlusive Crisis in Sickle Cell Disease.
Topics: Administration, Buccal; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Inflammator | 2016 |