ketorolac has been researched along with Osteoarthritis of Knee in 10 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Knee osteoarthritis is a disabling disease that costs billions of dollars to treat." | 6.82 | Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study. ( Bellamy, JL; Goff, BJ; Sayeed, SA, 2016) |
| "Ketorolac is an additional low-cost option for conservative management of primary osteoarthritis, and due to its differing mechanism of action, it may not propagate additional cartilage damage or preclude from early surgical intervention if unsuccessful." | 3.01 | Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial. ( Daines, SB; Fuerst, PG; Jurgensmeier, D; Jurgensmeier, K; Kunz, DE; Warth, LC, 2021) |
| "The outcome parameters were postoperative pain assessed by using a visual analog scale (VAS), the maximal angle of knee flexion, and quadriceps function from day 1 to 6 weeks after surgery." | 2.90 | Timing of periarticular injection has no effect on postoperative pain and functional recovery in simultaneous bilateral total knee arthroplasty: a prospective randomized, double-blinded trial. ( Jarusriwanna, A; Laoruengthana, A; Pongpirul, K; Rasamimongkol, S; Rattanaprichavej, P; Varakornpipat, P, 2019) |
| "Postoperative pain is one of the issues that concern most patients after total knee arthroplasty (TKA)." | 2.87 | Periarticular multimodal drug injection is better than single anesthetic drug in controlling pain after total knee arthroplasty. ( Kanitnate, S; Manuwong, S; Panichkul, P; Tammachote, N, 2018) |
| "Knee osteoarthritis is a disabling disease that costs billions of dollars to treat." | 2.82 | Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study. ( Bellamy, JL; Goff, BJ; Sayeed, SA, 2016) |
| "Ketorolac group members were given three weekly intra-articular injections of HA with ketorolac and then two weekly intra-articular injections of HA; and HA group members were given five weekly intra-articular HA injections." | 2.76 | Rapid analgesic onset of intra-articular hyaluronic acid with ketorolac in osteoarthritis of the knee. ( Chang, WH; Lee, SC; Rha, DW, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, M | 1 |
| Zhang, D | 1 |
| Shi, B | 1 |
| Jurgensmeier, K | 1 |
| Jurgensmeier, D | 1 |
| Kunz, DE | 1 |
| Fuerst, PG | 1 |
| Warth, LC | 1 |
| Daines, SB | 1 |
| Tammachote, N | 1 |
| Kanitnate, S | 1 |
| Manuwong, S | 1 |
| Panichkul, P | 1 |
| Laoruengthana, A | 1 |
| Jarusriwanna, A | 1 |
| Rattanaprichavej, P | 1 |
| Rasamimongkol, S | 1 |
| Varakornpipat, P | 1 |
| Pongpirul, K | 1 |
| Kulkarni, M | 1 |
| Mallesh, M | 1 |
| Wakankar, H | 1 |
| Prajapati, R | 1 |
| Pandit, H | 1 |
| Kelley, TC | 1 |
| Adams, MJ | 1 |
| Mulliken, BD | 1 |
| Dalury, DF | 1 |
| Kim, TW | 1 |
| Park, SJ | 1 |
| Lim, SH | 1 |
| Seong, SC | 1 |
| Lee, S | 1 |
| Lee, MC | 1 |
| Bellamy, JL | 1 |
| Goff, BJ | 1 |
| Sayeed, SA | 1 |
| Lee, SC | 1 |
| Rha, DW | 1 |
| Chang, WH | 1 |
| Martens, PB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study[NCT06081101] | Early Phase 1 | 80 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial[NCT04441112] | Phase 2/Phase 3 | 120 participants (Actual) | Interventional | 2018-05-20 | Completed | ||
| A Prospective, Randomized Trial Evaluating Regional Anesthesia, Long-Acting Local Anesthesia, and Traditional Care for Pain Control of Operatively Treated Ankle Fractures[NCT03696199] | Phase 4 | 70 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | ||
| KINCISE™ Surgical Automated System in Total Hip Arthroplasty (THA)[NCT05223777] | 50 participants (Anticipated) | Interventional | 2021-09-09 | Recruiting | |||
| Efficacy and Cost-effectiveness of Intra-Articular Ketorolac Injection for Knee Osteoarthritis: A Randomized, Controlled, Double-Blinded Study[NCT03694821] | Phase 4 | 18 participants (Actual) | Interventional | 2018-07-05 | Terminated (stopped due to Low enrollment) | ||
| The Effect of Different Intra-articular Injections on Pain and Function in Primary Gonarthrosis[NCT05291793] | 80 participants (Actual) | Interventional | 2020-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for ketorolac and Osteoarthritis of Knee
| Article | Year |
|---|---|
Comparison of the Post-Total Knee Arthroplasty Analgesic Effect of Intraoperative Periarticular Injection of Different Analgesics.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthroplas | 2019 |
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
Periarticular multimodal drug injection is better than single anesthetic drug in controlling pain after total knee arthroplasty.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Arthroplasty, Replacement, Knee; | 2018 |
Timing of periarticular injection has no effect on postoperative pain and functional recovery in simultaneous bilateral total knee arthroplasty: a prospective randomized, double-blinded trial.
Topics: Aged; Arthroplasty, Replacement, Knee; Bupivacaine; Double-Blind Method; Drug Administration Schedul | 2019 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Clonidine; Doub | 2013 |
Which analgesic mixture is appropriate for periarticular injection after total knee arthroplasty? Prospective, randomized, double-blind study.
Topics: Aged; Aged, 80 and over; Amides; Analgesics; Arthroplasty, Replacement, Knee; Double-Blind Method; D | 2015 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Rapid analgesic onset of intra-articular hyaluronic acid with ketorolac in osteoarthritis of the knee.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Drug Therapy, Combination; Female; Follow | 2011 |
2 other studies available for ketorolac and Osteoarthritis of Knee
| Article | Year |
|---|---|
Effect of Methylprednisolone in Periarticular Infiltration for Primary Total Knee Arthroplasty on Pain and Rehabilitation.
Topics: Aged; Arthroplasty, Replacement, Knee; Epinephrine; Female; Humans; Ketorolac; Knee Joint; Male; Met | 2019 |
Bilateral symmetric inflammatory reaction to hylan G-F 20 injection.
Topics: Aged; Antirheumatic Agents; Female; Glucocorticoids; Humans; Hyaluronic Acid; Injections, Intra-Arti | 2001 |