ketorolac has been researched along with Osteoarthritis, Hip in 3 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Osteoarthritis, Hip: Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.
Excerpt | Relevance | Reference |
---|---|---|
"Ketorolac is an additional low-cost option for conservative management of primary osteoarthritis, and due to its differing mechanism of action, it may not propagate additional cartilage damage or preclude from early surgical intervention if unsuccessful." | 3.01 | Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial. ( Daines, SB; Fuerst, PG; Jurgensmeier, D; Jurgensmeier, K; Kunz, DE; Warth, LC, 2021) |
"The treatment of osteoarthritis of the hip with intra-articular ketorolac injection is as effective as that with intra-articular corticosteroid injection." | 1.42 | Ultrasound guided intra-articular ketorolac versus corticosteroid injection in osteoarthritis of the hip: a retrospective comparative study. ( Ahn, J; Bae, BW; Kim, TK; Lee, WY; Park, KD; Park, Y, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (66.67) | 24.3611 |
2020's | 1 (33.33) | 2.80 |
Authors | Studies |
---|---|
Jurgensmeier, K | 1 |
Jurgensmeier, D | 1 |
Kunz, DE | 1 |
Fuerst, PG | 1 |
Warth, LC | 1 |
Daines, SB | 1 |
Park, KD | 1 |
Kim, TK | 1 |
Bae, BW | 1 |
Ahn, J | 1 |
Lee, WY | 1 |
Park, Y | 1 |
Busch, CA | 1 |
Whitehouse, MR | 1 |
Shore, BJ | 1 |
MacDonald, SJ | 1 |
McCalden, RW | 1 |
Bourne, RB | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study[NCT06081101] | Early Phase 1 | 80 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial[NCT04441112] | Phase 2/Phase 3 | 120 participants (Actual) | Interventional | 2018-05-20 | Completed | ||
Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures: A Randomized Controlled Trial[NCT02793947] | Phase 4 | 102 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
Efficacy of Postoperative Pain Control Between Transarticular VS Periartiucular Multimodal Drug Infiltration in Total Hip Arthroplasty: Double-blinded Randomized Control Trial[NCT05325671] | 120 participants (Anticipated) | Interventional | 2022-04-05 | Not yet recruiting | |||
Ultrasound-guided Pericapsular Nerve Group (PENG) Block vs. Intraoperative Local Anesthetic Infiltration (ILAI) for Total Hip Arthroplasty (THA): a Single Center, Non-inferiority Randomized Control Trial.[NCT05898581] | 40 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Patients will be monitored every 15 minutes in the recovery room and every 4 hours for the first two post-operative days by nursing personnel for medication side effects related to ropivacaine toxicity including blurred vision, hearing problems, transient peripheral paralysis, dizziness, convulsion, uncontrolled muscle contraction, hypotension, bradycardia, and new onset arrhythmia. (NCT02793947)
Timeframe: 48 hours following surgery
Intervention | Participants (Count of Participants) |
---|---|
Peri-incisional Injection | 0 |
Control (no Injection) | 0 |
Parenteral and oral narcotic agents will be utilized by patients for post-operative pain control per the standard of care. No alterations in narcotic prescription behavior will be observed for this study. (NCT02793947)
Timeframe: Narcotic consumption will be recorded every 8 hours for the first two post-operative days.
Intervention | mg of morphine (Mean) |
---|---|
Peri-incisional Injection | 5.0 |
Control (no Injection) | 9.7 |
"Patients will describe their current level of comfort on a 10 point scale while at rest. Zero corresponds to no pain and ten corresponds to the most extreme possible pain. Visual analog scores will be collected by nursing staff who are blinded to the treatment allocation." (NCT02793947)
Timeframe: Pain assessment will be collected immediately prior to surgery (pre-op), immediately following surgery in the post-anesthesia care unit (PACU), and every 4 hours following surgery for the first two post-operative days (48 hours total; 4H-48H)
Intervention | units on a scale (Median) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-op | PACU | 4H | 8H | 12H | 16H | 20H | 24H | 28H | 32H | 36H | 40H | 44H | 48H | |
Control (no Injection) | 5.0 | 3.2 | 5.0 | 5.0 | 5.0 | 4.0 | 4.0 | 4.0 | 3.5 | 5.0 | 4.0 | 3.5 | 4.0 | 3.0 |
Peri-incisional Injection | 5.0 | 1.6 | 1.0 | 2.0 | 3.5 | 3.5 | 4.0 | 3.0 | 3.0 | 3.0 | 4.0 | 3.0 | 3.0 | 3.0 |
2 trials available for ketorolac and Osteoarthritis, Hip
Article | Year |
---|---|
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr | 2021 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi | 2010 |
1 other study available for ketorolac and Osteoarthritis, Hip
Article | Year |
---|---|
Ultrasound guided intra-articular ketorolac versus corticosteroid injection in osteoarthritis of the hip: a retrospective comparative study.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Female; Humans; Inject | 2015 |