Page last updated: 2024-10-29

ketorolac and Osteoarthritis, Hip

ketorolac has been researched along with Osteoarthritis, Hip in 3 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Osteoarthritis, Hip: Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.

Research Excerpts

ExcerptRelevanceReference
"Ketorolac is an additional low-cost option for conservative management of primary osteoarthritis, and due to its differing mechanism of action, it may not propagate additional cartilage damage or preclude from early surgical intervention if unsuccessful."3.01Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial. ( Daines, SB; Fuerst, PG; Jurgensmeier, D; Jurgensmeier, K; Kunz, DE; Warth, LC, 2021)
"The treatment of osteoarthritis of the hip with intra-articular ketorolac injection is as effective as that with intra-articular corticosteroid injection."1.42Ultrasound guided intra-articular ketorolac versus corticosteroid injection in osteoarthritis of the hip: a retrospective comparative study. ( Ahn, J; Bae, BW; Kim, TK; Lee, WY; Park, KD; Park, Y, 2015)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Jurgensmeier, K1
Jurgensmeier, D1
Kunz, DE1
Fuerst, PG1
Warth, LC1
Daines, SB1
Park, KD1
Kim, TK1
Bae, BW1
Ahn, J1
Lee, WY1
Park, Y1
Busch, CA1
Whitehouse, MR1
Shore, BJ1
MacDonald, SJ1
McCalden, RW1
Bourne, RB1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study[NCT06081101]Early Phase 180 participants (Anticipated)Interventional2024-01-31Not yet recruiting
Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial[NCT04441112]Phase 2/Phase 3120 participants (Actual)Interventional2018-05-20Completed
Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures: A Randomized Controlled Trial[NCT02793947]Phase 4102 participants (Actual)Interventional2015-05-31Completed
Efficacy of Postoperative Pain Control Between Transarticular VS Periartiucular Multimodal Drug Infiltration in Total Hip Arthroplasty: Double-blinded Randomized Control Trial[NCT05325671]120 participants (Anticipated)Interventional2022-04-05Not yet recruiting
Ultrasound-guided Pericapsular Nerve Group (PENG) Block vs. Intraoperative Local Anesthetic Infiltration (ILAI) for Total Hip Arthroplasty (THA): a Single Center, Non-inferiority Randomized Control Trial.[NCT05898581]40 participants (Anticipated)Interventional2024-01-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Medication-related Side Effects

Patients will be monitored every 15 minutes in the recovery room and every 4 hours for the first two post-operative days by nursing personnel for medication side effects related to ropivacaine toxicity including blurred vision, hearing problems, transient peripheral paralysis, dizziness, convulsion, uncontrolled muscle contraction, hypotension, bradycardia, and new onset arrhythmia. (NCT02793947)
Timeframe: 48 hours following surgery

InterventionParticipants (Count of Participants)
Peri-incisional Injection0
Control (no Injection)0

Total Narcotic Consumption

Parenteral and oral narcotic agents will be utilized by patients for post-operative pain control per the standard of care. No alterations in narcotic prescription behavior will be observed for this study. (NCT02793947)
Timeframe: Narcotic consumption will be recorded every 8 hours for the first two post-operative days.

Interventionmg of morphine (Mean)
Peri-incisional Injection5.0
Control (no Injection)9.7

Visual Analog Scale Pain Assessment

"Patients will describe their current level of comfort on a 10 point scale while at rest. Zero corresponds to no pain and ten corresponds to the most extreme possible pain. Visual analog scores will be collected by nursing staff who are blinded to the treatment allocation." (NCT02793947)
Timeframe: Pain assessment will be collected immediately prior to surgery (pre-op), immediately following surgery in the post-anesthesia care unit (PACU), and every 4 hours following surgery for the first two post-operative days (48 hours total; 4H-48H)

,
Interventionunits on a scale (Median)
Pre-opPACU4H8H12H16H20H24H28H32H36H40H44H48H
Control (no Injection)5.03.25.05.05.04.04.04.03.55.04.03.54.03.0
Peri-incisional Injection5.01.61.02.03.53.54.03.03.03.04.03.03.03.0

Trials

2 trials available for ketorolac and Osteoarthritis, Hip

ArticleYear
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
    The Journal of arthroplasty, 2021, Volume: 36, Issue:2

    Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr

2021
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
    The Journal of arthroplasty, 2021, Volume: 36, Issue:2

    Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr

2021
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
    The Journal of arthroplasty, 2021, Volume: 36, Issue:2

    Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr

2021
Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial.
    The Journal of arthroplasty, 2021, Volume: 36, Issue:2

    Topics: Double-Blind Method; Humans; Injections, Intra-Articular; Ketorolac; Osteoarthritis, Hip; Osteoarthr

2021
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010
The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty.
    Clinical orthopaedics and related research, 2010, Volume: 468, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioi

2010

Other Studies

1 other study available for ketorolac and Osteoarthritis, Hip

ArticleYear
Ultrasound guided intra-articular ketorolac versus corticosteroid injection in osteoarthritis of the hip: a retrospective comparative study.
    Skeletal radiology, 2015, Volume: 44, Issue:9

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Female; Humans; Inject

2015