Page last updated: 2024-10-29
ketorolac and Orthopedic Disorders
ketorolac has been researched along with Orthopedic Disorders in 1 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain." | 9.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
| "To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain." | 5.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Turturro, MA | 1 |
| Paris, PM | 1 |
| Seaberg, DC | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339] | Phase 4 | 300 participants (Anticipated) | Interventional | 2018-01-15 | Recruiting |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trials
1 trial available for ketorolac and Orthopedic Disorders