ketorolac has been researched along with Neuralgia in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Local injection of ketorolac, a nonselective COX inhibitor, into the ipsilateral plantar side or into the injury site of the sciatic nerve, effectively reversed the tactile allodynia induced by PSNL for > 5 days." | 3.71 | Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. ( Eisenach, JC; Ma, W, 2002) |
| "Although current neuropathic pain treatment guidelines do not recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs), whether NSAIDs can serve as a useful adjuvant to conventional multimodal therapy remains unclear." | 1.51 | Synergistic symptom-specific effects of ketorolac-tramadol and ketorolac-pregabalin in a rat model of peripheral neuropathy. ( Cheng, YT; Huang, YH; Lin, FS; Lin, WY; Sun, WZ; Yen, CT, 2019) |
| "Tactile allodynia was assessed 7 days after the surgery by measuring hindpaw withdrawal threshold to probing with von Frey filaments." | 1.30 | Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. ( Hunter, JC; Lashbrook, JM; Ossipov, MH; Porreca, F; Raffa, RB; Tallarida, RJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, WY | 2 |
| Sun, WZ | 2 |
| Yen, CT | 2 |
| Tseng, HF | 1 |
| Hung, CJ | 1 |
| Cheng, YT | 1 |
| Huang, YH | 1 |
| Lin, FS | 1 |
| Kausar, F | 1 |
| Davis, MP | 1 |
| Lashbrook, JM | 1 |
| Ossipov, MH | 1 |
| Hunter, JC | 1 |
| Raffa, RB | 1 |
| Tallarida, RJ | 1 |
| Porreca, F | 1 |
| Ma, W | 1 |
| Eisenach, JC | 1 |
6 other studies available for ketorolac and Neuralgia
| Article | Year |
|---|---|
Reply "Co-analgesics for neuropathic pain in the rat model of spared nerve injury".
Topics: Analgesics; Animals; Ketorolac; Neuralgia; Pregabalin; Rats; Tramadol | 2019 |
Co-analgesics for neuropathic pain in the rat model of spared nerve injury.
Topics: Analgesics; Animals; Ketorolac; Neuralgia; Pregabalin; Rats; Tramadol | 2019 |
Synergistic symptom-specific effects of ketorolac-tramadol and ketorolac-pregabalin in a rat model of peripheral neuropathy.
Topics: Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ketorolac; Male; Meloxic | 2019 |
Ketorolac in neuropathic pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brachial Plexus Neuropathies; Breast Neoplasms; Carcinoma, | 2006 |
Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Hyperalgesia; Injections, Sp | 1999 |
Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2002 |