ketorolac has been researched along with Neoplasms in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketorolac was associated with greater likelihood of complete pain relief, but the data were heterogeneous." | 2.82 | Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review. ( Butcher, B; Clark, K; Currow, D; Fazekas, B; Hutchings, E; Rowett, D, 2022) |
| "University Cancer Center." | 2.67 | Comparison of morphine and ketorolac for intravenous patient-controlled analgesia in postoperative cancer patients. ( Bosek, V; Miguel, R, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Butcher, B | 1 |
| Hutchings, E | 1 |
| Fazekas, B | 1 |
| Clark, K | 1 |
| Rowett, D | 1 |
| Currow, D | 1 |
| Scarlett, JM | 1 |
| Zhu, X | 1 |
| Enriori, PJ | 1 |
| Bowe, DD | 1 |
| Batra, AK | 1 |
| Levasseur, PR | 1 |
| Grant, WF | 1 |
| Meguid, MM | 1 |
| Cowley, MA | 1 |
| Marks, DL | 1 |
| Bosek, V | 1 |
| Miguel, R | 1 |
| De Conno, F | 1 |
| Zecca, E | 1 |
| Martini, C | 1 |
| Ripamonti, C | 1 |
| Caraceni, A | 1 |
| Saita, L | 1 |
| Blackwell, N | 1 |
| Bangham, L | 1 |
| Hughes, M | 1 |
| Melzack, D | 1 |
| Trotman, I | 1 |
| Hughes, A | 1 |
| Wilcock, A | 1 |
| Corcoran, R | 1 |
1 review available for ketorolac and Neoplasms
| Article | Year |
|---|---|
Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cancer Pain; Humans; Ketorolac; Neoplas | 2022 |
3 trials available for ketorolac and Neoplasms
| Article | Year |
|---|---|
Comparison of morphine and ketorolac for intravenous patient-controlled analgesia in postoperative cancer patients.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; | 1994 |
Subcutaneous ketorolac--a new development in pain control.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female; | 1993 |
Ketorolac: continuous subcutaneous infusion for cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Adm | 1997 |
2 other studies available for ketorolac and Neoplasms
| Article | Year |
|---|---|
Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
Topics: Agouti-Related Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arcuate Nucleus of Hypotha | 2008 |
Tolerability of ketorolac administered via continuous subcutaneous infusion for cancer pain: a preliminary report.
Topics: Adult; Aged; Analgesics; Female; Humans; Infusions, Parenteral; Ketorolac; Male; Middle Aged; Neopla | 1994 |