Page last updated: 2024-10-29

ketorolac and Neoplasms

ketorolac has been researched along with Neoplasms in 6 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Ketorolac was associated with greater likelihood of complete pain relief, but the data were heterogeneous."2.82Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review. ( Butcher, B; Clark, K; Currow, D; Fazekas, B; Hutchings, E; Rowett, D, 2022)
"University Cancer Center."2.67Comparison of morphine and ketorolac for intravenous patient-controlled analgesia in postoperative cancer patients. ( Bosek, V; Miguel, R, 1994)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Butcher, B1
Hutchings, E1
Fazekas, B1
Clark, K1
Rowett, D1
Currow, D1
Scarlett, JM1
Zhu, X1
Enriori, PJ1
Bowe, DD1
Batra, AK1
Levasseur, PR1
Grant, WF1
Meguid, MM1
Cowley, MA1
Marks, DL1
Bosek, V1
Miguel, R1
De Conno, F1
Zecca, E1
Martini, C1
Ripamonti, C1
Caraceni, A1
Saita, L1
Blackwell, N1
Bangham, L1
Hughes, M1
Melzack, D1
Trotman, I1
Hughes, A1
Wilcock, A1
Corcoran, R1

Reviews

1 review available for ketorolac and Neoplasms

ArticleYear
Opioid-sparing effects of ketorolac in palliative care patients receiving opioids for chronic cancer-related pain: A systematic literature review.
    Palliative medicine, 2022, Volume: 36, Issue:1

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cancer Pain; Humans; Ketorolac; Neoplas

2022

Trials

3 trials available for ketorolac and Neoplasms

ArticleYear
Comparison of morphine and ketorolac for intravenous patient-controlled analgesia in postoperative cancer patients.
    The Clinical journal of pain, 1994, Volume: 10, Issue:4

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans;

1994
Subcutaneous ketorolac--a new development in pain control.
    Palliative medicine, 1993, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female;

1993
Ketorolac: continuous subcutaneous infusion for cancer pain.
    Journal of pain and symptom management, 1997, Volume: 13, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Adm

1997

Other Studies

2 other studies available for ketorolac and Neoplasms

ArticleYear
Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
    Endocrinology, 2008, Volume: 149, Issue:10

    Topics: Agouti-Related Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arcuate Nucleus of Hypotha

2008
Tolerability of ketorolac administered via continuous subcutaneous infusion for cancer pain: a preliminary report.
    Journal of pain and symptom management, 1994, Volume: 9, Issue:2

    Topics: Adult; Aged; Analgesics; Female; Humans; Infusions, Parenteral; Ketorolac; Male; Middle Aged; Neopla

1994