ketorolac has been researched along with Muscle Contraction in 3 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pravadoline was also inhibitory in the MVD." | 1.28 | Antinociceptive (aminoalkyl)indoles. ( Bell, MR; D'Ambra, TE; Daum, SJ; Eissenstat, MA; Herrmann, JL; Hlasta, DJ; Kumar, V; Philion, RE; Rosi, D; Wetzel, JR, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, MR | 1 |
| D'Ambra, TE | 1 |
| Kumar, V | 1 |
| Eissenstat, MA | 1 |
| Herrmann, JL | 1 |
| Wetzel, JR | 1 |
| Rosi, D | 1 |
| Philion, RE | 1 |
| Daum, SJ | 1 |
| Hlasta, DJ | 1 |
| Crecelius, AR | 1 |
| Kirby, BS | 1 |
| Hearon, CM | 1 |
| Luckasen, GJ | 1 |
| Larson, DG | 1 |
| Dinenno, FA | 1 |
| Wen, CC | 1 |
| Coyle, TL | 1 |
| Jerde, TJ | 1 |
| Nakada, SY | 1 |
1 trial available for ketorolac and Muscle Contraction
| Article | Year |
|---|---|
Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+) /K(+) -ATPase inhibition.
Topics: Adenosine; Adult; Barium Compounds; Brachial Artery; Chlorides; Exercise; Female; Forearm; Hand Stre | 2015 |
2 other studies available for ketorolac and Muscle Contraction
| Article | Year |
|---|---|
Antinociceptive (aminoalkyl)indoles.
Topics: Analgesia; Analgesics; Animals; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Indoles; M | 1991 |
Ketorolac effectively inhibits ureteral contractility in vitro.
Topics: Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; In Vitro Techniques; Indometha | 2008 |