Page last updated: 2024-10-29

ketorolac and Meniscitis

ketorolac has been researched along with Meniscitis in 1 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dogan, N1
Erdem, AF1
Gundogdu, C1
Kursad, H1
Kizilkaya, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections: a Prospective Double-Blinded Randomized Trial[NCT04895280]Phase 4400 participants (Anticipated)Interventional2024-04-30Not yet recruiting
Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial[NCT04115644]Phase 482 participants (Actual)Interventional2017-05-01Terminated (stopped due to Covid-19 and we failed to submit annual report for 2017 and 2018)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Visual Analog Scale

Pain as measured by the Visual Analog Scale after first injection. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Baseline - immediately after the injection

Interventionscore on a scale (Mean)
Group 1 (Control)3.197
Group 2 (Ketorolac)3.577
Group 3 (Kenalog)3.677

Visual Analog Scale

Pain as measured by the Visual Analog Scale prior to first injection. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Baseline - pre-injection

Interventionscore on a scale (Mean)
Group 1 (Control)5.77
Group 2 (Ketorolac)4.57
Group 3 (Kenalog)4.67

Visual Analog Scale

Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Day 2

Interventionscore on a scale (Mean)
Group 1 (Control)2.347
Group 2 (Ketorolac)2.837
Group 3 (Kenalog)2.67

Visual Analog Scale

Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 1

Interventionscore on a scale (Mean)
Group 1 (Control)3.397
Group 2 (Ketorolac)3.7
Group 3 (Kenalog)3.257

Visual Analog Scale

Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 12

Interventionscore on a scale (Mean)
Group 1 (Control)3.447
Group 2 (Ketorolac)1.417
Group 3 (Kenalog)2.027

Visual Analog Scale

Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 2

Interventionscore on a scale (Mean)
Group 1 (Control)3.547
Group 2 (Ketorolac)2.67
Group 3 (Kenalog)2.57

Visual Analog Scale

Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 4

Interventionscore on a scale (Mean)
Group 1 (Control)3.547
Group 2 (Ketorolac)2.67
Group 3 (Kenalog)2.317

Visual Analog Scale

Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 6

Interventionscore on a scale (Mean)
Group 1 (Control)3.357
Group 2 (Ketorolac)2.757
Group 3 (Kenalog)2.687

Other Studies

1 other study available for ketorolac and Meniscitis

ArticleYear
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
    Canadian journal of physiology and pharmacology, 2004, Volume: 82, Issue:7

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma

2004
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
    Canadian journal of physiology and pharmacology, 2004, Volume: 82, Issue:7

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma

2004
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
    Canadian journal of physiology and pharmacology, 2004, Volume: 82, Issue:7

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma

2004
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
    Canadian journal of physiology and pharmacology, 2004, Volume: 82, Issue:7

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma

2004