ketorolac has been researched along with Meningitis, Pneumococcal in 2 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study used a rabbit model of hearing loss in experimental pneumococcal meningitis to evaluate the therapeutic effect of two anti-inflammatory agents, dexamethasone and ketorolac, coadministered with ampicillin." | 7.70 | Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. ( Bhatt, SM; Burkard, RF; Merchant, SN; Nadol, JB; Rappaport, JM, 1999) |
| " This study used a rabbit model of hearing loss in experimental pneumococcal meningitis to evaluate the therapeutic effect of two anti-inflammatory agents, dexamethasone and ketorolac, coadministered with ampicillin." | 3.70 | Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. ( Bhatt, SM; Burkard, RF; Merchant, SN; Nadol, JB; Rappaport, JM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Basu, S | 1 |
| Varghese, R | 1 |
| Debroy, R | 1 |
| Ramaiah, S | 1 |
| Veeraraghavan, B | 1 |
| Anbarasu, A | 1 |
| Rappaport, JM | 1 |
| Bhatt, SM | 1 |
| Burkard, RF | 1 |
| Merchant, SN | 1 |
| Nadol, JB | 1 |
2 other studies available for ketorolac and Meningitis, Pneumococcal
| Article | Year |
|---|---|
Non-steroidal anti-inflammatory drugs ketorolac and etodolac can augment the treatment against pneumococcal meningitis by targeting penicillin-binding proteins.
Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bact | 2022 |
Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac.
Topics: Acoustic Stimulation; Ampicillin; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-S | 1999 |