ketorolac has been researched along with Low Back Ache in 9 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain." | 9.19 | Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014) |
| "The study objective was to assess the efficacy and patient acceptance of ketorolac as an alternative to meperidine for the treatment of severe musculoskeletal low back pain (LBP)." | 9.09 | Ketorolac versus meperidine: ED treatment of severe musculoskeletal low back pain. ( Leahey, N; Schneider, S; Veenema, KR, 2000) |
| "The aim of this study was to compare the efficacy of KT and naproxen (NA) in the treatment of acute low back pain (LBP) of moderate-to-severe intensity." | 7.83 | Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain. ( Amazonas, RB; Bocchi de Oliveira, MF; Ecclissato, Cda C; Plapler, PG; Scheinberg, MA, 2016) |
| "Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain." | 5.19 | Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014) |
| "The study objective was to assess the efficacy and patient acceptance of ketorolac as an alternative to meperidine for the treatment of severe musculoskeletal low back pain (LBP)." | 5.09 | Ketorolac versus meperidine: ED treatment of severe musculoskeletal low back pain. ( Leahey, N; Schneider, S; Veenema, KR, 2000) |
| "The aim of this study was to compare the efficacy of KT and naproxen (NA) in the treatment of acute low back pain (LBP) of moderate-to-severe intensity." | 3.83 | Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain. ( Amazonas, RB; Bocchi de Oliveira, MF; Ecclissato, Cda C; Plapler, PG; Scheinberg, MA, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Slawson, DC | 1 |
| Irizarry, E | 1 |
| Restivo, A | 1 |
| Salama, M | 1 |
| Davitt, M | 1 |
| Feliciano, C | 1 |
| Cortijo-Brown, A | 1 |
| Friedman, BW | 1 |
| Tanen, DA | 1 |
| Shimada, M | 1 |
| Danish, DC | 1 |
| Dos Santos, F | 1 |
| Makela, M | 1 |
| Riffenburgh, RH | 1 |
| Vygonskaya, MV | 1 |
| Filatova, EG | 1 |
| Plapler, PG | 1 |
| Scheinberg, MA | 1 |
| Ecclissato, Cda C | 1 |
| Bocchi de Oliveira, MF | 1 |
| Amazonas, RB | 1 |
| Young, KM | 1 |
| Hubbell, K | 1 |
| Le Roux, PD | 1 |
| Samudrala, S | 1 |
| Veenema, KR | 1 |
| Leahey, N | 1 |
| Schneider, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind, Double Dummy To Non-Inferiority Comparison Of Ketorolac Tromethamine Versus Naproxen For Moderate to Severe Back Pain Treatment[NCT01471886] | Phase 3 | 83 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketorolac and Low Back Ache
| Article | Year |
|---|---|
[Muscle-skeletal pain].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Combined Modality Therapy; Humans; Ketorolac; | 2016 |
4 trials available for ketorolac and Low Back Ache
| Article | Year |
|---|---|
A randomized controlled trial of ibuprofen versus ketorolac versus diclofenac for acute, nonradicular low back pain.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibupro | 2021 |
Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial.
Topics: Acute Pain; Administration, Intravenous; Adult; Anesthetics, Local; Cyclooxygenase Inhibitors; Doubl | 2014 |
Postoperative pain after lumbar disc surgery: a comparison between parenteral ketorolac and narcotics.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 1999 |
Ketorolac versus meperidine: ED treatment of severe musculoskeletal low back pain.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Low B | 2000 |
4 other studies available for ketorolac and Low Back Ache
| Article | Year |
|---|---|
Ibuprofen, Ketorolac, and Diclofenac Are Equivalent for the Treatment of Acute, Nonradicular Low Back Pain.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ibupro | 2022 |
Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketorolac; Low Back Pain; Napr | 2016 |
Simple rules, complex behavior.
Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Constipation; Diagnosis, D | 2008 |
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int | 1996 |