ketorolac has been researched along with Lock Jaw in 3 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale." | 3.01 | Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. ( Araújo, FA; Barros, AM; Lucena, EE; Martins-de-Barros, AV; Sette de Souza, PH; Siqueira, AK, 2021) |
| "Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated." | 2.77 | Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. ( Brozoski, DT; Calvo, AM; Colombini-Ishikiriama, BL; Dionísio, TJ; Faria, FA; Giglio, FP; Lauris, JR; Modena, KC; Ribeiro, DA; Santos, CF; Trindade, PA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Martins-de-Barros, AV | 1 |
| Barros, AM | 1 |
| Siqueira, AK | 1 |
| Lucena, EE | 1 |
| Sette de Souza, PH | 1 |
| Araújo, FA | 1 |
| Isiordia-Espinoza, MA | 1 |
| Sánchez-Prieto, M | 1 |
| Tobías-Azúa, F | 1 |
| Reyes-García, JG | 1 |
| Trindade, PA | 1 |
| Giglio, FP | 1 |
| Colombini-Ishikiriama, BL | 1 |
| Calvo, AM | 1 |
| Modena, KC | 1 |
| Ribeiro, DA | 1 |
| Dionísio, TJ | 1 |
| Brozoski, DT | 1 |
| Lauris, JR | 1 |
| Faria, FA | 1 |
| Santos, CF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preemptive Use of Etoricoxib and Dexamethasone: Effect on Early Bone Healing, Inflammatory Response, and Postoperative Parameters After Impacted Lower Third Molar Surgery[NCT05791721] | Phase 4 | 90 participants (Actual) | Interventional | 2021-10-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for ketorolac and Lock Jaw
| Article | Year |
|---|---|
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial.
Topics: Dexamethasone; Double-Blind Method; Edema; Female; Humans; Ketorolac; Male; Molar, Third; Pain, Post | 2021 |
Pre-emptive analgesic effectiveness of meloxicam versus tramadol after mandibular third molar surgery: a pilot study.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; | 2012 |
Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal.
Topics: Analysis of Variance; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Edema; Fem | 2012 |