Page last updated: 2024-10-30

ketorolac and Lock Jaw

ketorolac has been researched along with Lock Jaw in 3 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale."3.01Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. ( Araújo, FA; Barros, AM; Lucena, EE; Martins-de-Barros, AV; Sette de Souza, PH; Siqueira, AK, 2021)
"Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated."2.77Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. ( Brozoski, DT; Calvo, AM; Colombini-Ishikiriama, BL; Dionísio, TJ; Faria, FA; Giglio, FP; Lauris, JR; Modena, KC; Ribeiro, DA; Santos, CF; Trindade, PA, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Martins-de-Barros, AV1
Barros, AM1
Siqueira, AK1
Lucena, EE1
Sette de Souza, PH1
Araújo, FA1
Isiordia-Espinoza, MA1
Sánchez-Prieto, M1
Tobías-Azúa, F1
Reyes-García, JG1
Trindade, PA1
Giglio, FP1
Colombini-Ishikiriama, BL1
Calvo, AM1
Modena, KC1
Ribeiro, DA1
Dionísio, TJ1
Brozoski, DT1
Lauris, JR1
Faria, FA1
Santos, CF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Preemptive Use of Etoricoxib and Dexamethasone: Effect on Early Bone Healing, Inflammatory Response, and Postoperative Parameters After Impacted Lower Third Molar Surgery[NCT05791721]Phase 490 participants (Actual)Interventional2021-10-11Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for ketorolac and Lock Jaw

ArticleYear
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial.
    Medicina oral, patologia oral y cirugia bucal, 2021, Mar-01, Volume: 26, Issue:2

    Topics: Dexamethasone; Double-Blind Method; Edema; Female; Humans; Ketorolac; Male; Molar, Third; Pain, Post

2021
Pre-emptive analgesic effectiveness of meloxicam versus tramadol after mandibular third molar surgery: a pilot study.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012, Volume: 70, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method;

2012
Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2012, Volume: 114, Issue:1

    Topics: Analysis of Variance; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Edema; Fem

2012