ketorolac has been researched along with Kidney Diseases in 13 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The parameters considered as prognostic factors were pain relief with ketorolac (K) or ketorolac plus opiate treatment (KO), and stone size (>or= or <6 mm)." | 3.71 | Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic. ( Prina, LD; Rancatore, E; Secic, M; Weber, RE, 2002) |
| "In the patients with renal colic the average resistive index (RI) was significantly greater on the side of the colic after administration of either indomethacin or ketorolac (p<0." | 2.71 | Resistive index in patients with renal colic: differences after medical treatment with indomethacin and ketorolac. ( Bertolotto, M; Calderan, L; Gasparini, C; Pozzi Mucelli, R; Quaia, E, 2003) |
| "Ketorolac, which may cause renal vasoconstriction by cyclooxygenase inhibition, is often administered to patients anesthetized with sevoflurane that is metabolized to inorganic fluoride (F(-)), another potential nephrotoxin." | 2.70 | Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery. ( Eriksson, H; Koivusalo, AM; Laisalmi, M; Lindgren, L; Pere, P; Rosenberg, P, 2001) |
| " The time to first administration of rescue analgesic, up to 24 h following dosing with the study medication, was recorded." | 2.67 | A comparison of intramuscular ketorolac and pethidine in the alleviation of renal colic. ( Arkell, DG; Fletcher, MS; Iacovou, JW; Kaisary, AV; Philip, NH; Sandhu, DP, 1994) |
| "Twenty-five patients with renal colic were participants." | 1.29 | The use of intravenous ketorolac for the treatment of renal colic in the emergency department. ( Allegra, JR; Larsen, LS; Miller, A, 1993) |
| "Ketorolac proved safe for short-term intravenous use in children more than 1 year of age when patients with known contraindications to the use of non-steroidal antiinflammatory drugs were excluded." | 1.29 | Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. ( Berde, CB; Houck, CS; McDermott, JS; Sethna, NF; Wilder, RT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prina, LD | 1 |
| Rancatore, E | 1 |
| Secic, M | 1 |
| Weber, RE | 1 |
| Bertolotto, M | 1 |
| Quaia, E | 1 |
| Gasparini, C | 1 |
| Calderan, L | 1 |
| Pozzi Mucelli, R | 1 |
| Safdar, B | 1 |
| Degutis, LC | 1 |
| Landry, K | 1 |
| Vedere, SR | 1 |
| Moscovitz, HC | 1 |
| D'Onofrio, G | 1 |
| Sandhu, DP | 1 |
| Iacovou, JW | 1 |
| Fletcher, MS | 1 |
| Kaisary, AV | 1 |
| Philip, NH | 1 |
| Arkell, DG | 1 |
| Larsen, LS | 1 |
| Miller, A | 1 |
| Allegra, JR | 1 |
| Cordell, WH | 1 |
| Wright, SW | 1 |
| Wolfson, AB | 1 |
| Timerding, BL | 1 |
| Maneatis, TJ | 1 |
| Lewis, RH | 1 |
| Bynum, L | 1 |
| Nelson, DR | 1 |
| Houck, CS | 1 |
| Wilder, RT | 1 |
| McDermott, JS | 1 |
| Sethna, NF | 1 |
| Berde, CB | 1 |
| Stein, A | 1 |
| Ben Dov, D | 1 |
| Finkel, B | 1 |
| Mecz, Y | 1 |
| Kitzes, R | 1 |
| Lurie, A | 1 |
| Bergus, GR | 1 |
| Cohen, E | 1 |
| Hafner, R | 1 |
| Rotenberg, Z | 1 |
| Fadilla, M | 1 |
| Garty, M | 1 |
| Nicolás Torralba, JA | 1 |
| Rigabert Montiel, M | 1 |
| Bañón Pérez, V | 1 |
| Valdelvira Nadal, P | 1 |
| Pérez Albacete, M | 1 |
| Di Trolio, RN | 1 |
| Sing, RF | 1 |
| Bates, GM | 1 |
| Laisalmi, M | 1 |
| Eriksson, H | 1 |
| Koivusalo, AM | 1 |
| Pere, P | 1 |
| Rosenberg, P | 1 |
| Lindgren, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial Comparing the Combination of Intravenous Lidocaine and Ketorolac to Either Analgesics Alone for ED Patients With Acute Renal Colic[NCT02902770] | Phase 4 | 150 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The trial will compare the patient's pain score on a 11 point Likert scale, ranging from 0 to 10 with 0 being no pain, 5 moderate pain and 10 very severe pain, at 30 minutes (NCT02902770)
Timeframe: 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Lidocaine and Normal Saline Push | 5.52 |
| Ketorolac and Normal Saline Drip | 3.88 |
| Lidocaine and Ketorolac | 3.14 |
9 trials available for ketorolac and Kidney Diseases
| Article | Year |
|---|---|
Resistive index in patients with renal colic: differences after medical treatment with indomethacin and ketorolac.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Colic; Humans; Indomethacin; Ketorolac; Kidn | 2003 |
Intravenous morphine plus ketorolac is superior to either drug alone for treatment of acute renal colic.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Double-Blind | 2006 |
A comparison of intramuscular ketorolac and pethidine in the alleviation of renal colic.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Colic; Double-B | 1994 |
Comparison of intravenous ketorolac, meperidine, and both (balanced analgesia) for renal colic.
Topics: Adult; Aged; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; Double-Blind Method; Dr | 1996 |
Single-dose intramuscular ketorolac versus diclofenac for pain management in renal colic.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Double-Blind Method; Female | 1996 |
Pain relief for renal colic.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Double-Blind Method; Drug | 1996 |
Comparison of ketorolac and diclofenac in the treatment of renal colic.
Topics: Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Coli | 1998 |
[Intramuscular ketorolac compared to subcutaneous tramadol in the initial emergency treatment of renal colic].
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Colic; Emergencies; Humans; Injections, Intramuscular; | 1999 |
Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery.
Topics: Acetylglucosaminidase; Adult; Anesthetics, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Biom | 2001 |
4 other studies available for ketorolac and Kidney Diseases
| Article | Year |
|---|---|
Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Emergency Service, Hospital; Fem | 2002 |
The use of intravenous ketorolac for the treatment of renal colic in the emergency department.
Topics: Adult; Analgesics; Colic; Emergencies; Humans; Injections, Intravenous; Ketorolac; Kidney Diseases; | 1993 |
Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Prescho | 1996 |
Use of ketorolac in renal colic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Humans; Ketorolac; Kidney Diseases; Male; Middle Age | 1999 |