ketorolac has been researched along with Intraocular Pressure in 9 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To verify the influence of a non-steroidal anti-inflammatory drug (NSAID), ketorolac (topical and oral) on the intraocular pressure reduction induced by 0." | 9.13 | Topical and oral ketorolac administration increases the intraocular pressure-lowering effect of latanoprost. ( Campa, C; Costagliola, C; Incorvaia, C; Parmeggiani, F; Perri, P; Romano, MR, 2008) |
| "To elucidate an association between latanoprost and clinically significant cystoid macular edema (CME) in patients after uneventful phacoemulsification with intraocular lens implantation." | 7.71 | Latanoprost and clinically significant cystoid macular edema after uneventful phacoemulsification with intraocular lens implantation. ( Ramanathan, S; Yeh, PC, 2002) |
| "Patients older than 18 years with intraocular pressure (IOP) of more than 18 mmHg for whom the clinician decided SLT was the appropriately indicated therapy were randomized to 1 of 3 groups in a ratio of 1:1:1 as follows: ketorolac 0." | 5.30 | SALT Trial: Steroids after Laser Trabeculoplasty: Impact of Short-Term Anti-inflammatory Treatment on Selective Laser Trabeculoplasty Efficacy. ( Albeiruti, E; Fajardo, R; Goldberg, JL; Groth, SL; Loewen, N; Nunez, M; Schuman, JS; Sharpsten, L, 2019) |
| "Between July 2005 and October 2007, 61 consecutive medically uncontrolled glaucoma patients scheduled for first-time trabeculectomy were randomized to 1 of 3 study topical medication groups: nonsteroidal anti-inflammatory drugs (ketorolac), steroids (fluorometholone), or placebo (artificial tears)." | 5.14 | Preoperative nonsteroidal anti-inflammatory drug or steroid and outcomes after trabeculectomy: a randomized controlled trial. ( Breusegem, C; Fieuws, S; Renier, C; Spielberg, L; Stalmans, I; Van de Veire, S; Van Ginderdeuren, R; Vandewalle, E; Zeyen, T, 2010) |
| "To verify the influence of a non-steroidal anti-inflammatory drug (NSAID), ketorolac (topical and oral) on the intraocular pressure reduction induced by 0." | 5.13 | Topical and oral ketorolac administration increases the intraocular pressure-lowering effect of latanoprost. ( Campa, C; Costagliola, C; Incorvaia, C; Parmeggiani, F; Perri, P; Romano, MR, 2008) |
| "To elucidate an association between latanoprost and clinically significant cystoid macular edema (CME) in patients after uneventful phacoemulsification with intraocular lens implantation." | 3.71 | Latanoprost and clinically significant cystoid macular edema after uneventful phacoemulsification with intraocular lens implantation. ( Ramanathan, S; Yeh, PC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Groth, SL | 1 |
| Albeiruti, E | 1 |
| Nunez, M | 1 |
| Fajardo, R | 1 |
| Sharpsten, L | 1 |
| Loewen, N | 1 |
| Schuman, JS | 1 |
| Goldberg, JL | 1 |
| Phillis, CA | 1 |
| Bourke, RD | 1 |
| Lee, TH | 1 |
| Choi, W | 1 |
| Ji, YS | 1 |
| Yoon, KC | 1 |
| Sahu, S | 1 |
| Ram, J | 1 |
| Bansal, R | 1 |
| Pandav, SS | 1 |
| Gupta, A | 1 |
| Costagliola, C | 1 |
| Campa, C | 1 |
| Perri, P | 1 |
| Parmeggiani, F | 1 |
| Romano, MR | 1 |
| Incorvaia, C | 1 |
| Maca, SM | 1 |
| Amon, M | 1 |
| Findl, O | 1 |
| Kahraman, G | 1 |
| Barisani-Asenbauer, T | 1 |
| Breusegem, C | 1 |
| Spielberg, L | 1 |
| Van Ginderdeuren, R | 1 |
| Vandewalle, E | 1 |
| Renier, C | 1 |
| Van de Veire, S | 1 |
| Fieuws, S | 1 |
| Zeyen, T | 1 |
| Stalmans, I | 1 |
| Yeh, PC | 1 |
| Ramanathan, S | 1 |
| Kim, SJ | 1 |
| Adams, NA | 1 |
| Toma, HS | 1 |
| Belair, ML | 1 |
| Thorne, JE | 1 |
| Green, WR | 1 |
| Jabs, DA | 1 |
5 trials available for ketorolac and Intraocular Pressure
| Article | Year |
|---|---|
SALT Trial: Steroids after Laser Trabeculoplasty: Impact of Short-Term Anti-inflammatory Treatment on Selective Laser Trabeculoplasty Efficacy.
Topics: Administration, Ophthalmic; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Fema | 2019 |
Effect of topical ketorolac 0.4%, nepafenac 0.1%, and bromfenac 0.09% on postoperative inflammation using laser flare photometry in patients having phacoemulsification.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Be | 2015 |
Topical and oral ketorolac administration increases the intraocular pressure-lowering effect of latanoprost.
Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Antihyperten | 2008 |
Efficacy and tolerability of preservative-free and preserved diclofenac and preserved ketorolac eyedrops after cataract surgery.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Benzalkonium Compounds; Diclofenac | 2010 |
Preoperative nonsteroidal anti-inflammatory drug or steroid and outcomes after trabeculectomy: a randomized controlled trial.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antihyper | 2010 |
4 other studies available for ketorolac and Intraocular Pressure
| Article | Year |
|---|---|
Bilateral Subretinal Fluid Mimicking Subretinal Neovascularization Within 24 Hours After Selective Laser Trabeculoplasty.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood-Retinal Barrier; Corneal Pachymetry; Drug Thera | 2016 |
Comparison of ketorolac 0.45% versus diclofenac 0.1% for macular thickness and volume after uncomplicated cataract surgery.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Intrao | 2016 |
Latanoprost and clinically significant cystoid macular edema after uneventful phacoemulsification with intraocular lens implantation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Glaucoma, Open-Angle; Humans; Intr | 2002 |
Safety of intravitreal ketorolac and diclofenac: an electroretinographic and histopathologic study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dark Adaptation; Diclofenac; Electroretinography; | 2008 |