Page last updated: 2024-10-29

ketorolac and Inguinal Hernia

ketorolac has been researched along with Inguinal Hernia in 11 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"In this prospective, randomized, double-blinded study we sought to evaluate the efficacy and safety of combined use of intravenous ketorolac and acetaminophen in small children undergoing outpatient inguinal hernia repair."9.14Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children. ( Hong, JY; Kil, HK; Kim, WO; Won Han, S, 2010)
"Diclofenac suppository 50 mg and intravenous ketorolac 30 mg provided equivalent postoperative analgesia following ambulatory inguinal hernia repair under general anaesthesia."9.10Prospective randomized trial of pre-emptive analgesics following ambulatory inguinal hernia repair: intravenous ketorolac versus diclofenac suppository. ( Goh, LC; Lau, H; Lee, F; Patil, NG; Wong, C, 2002)
"For children undergoing inguinal surgery, the administration of a single dose of intravenous morphine after the induction of anesthesia smooths emergence from anesthesia as assessed by improved cooperation and sedation in the PACU, decreases the need for postoperative analgesics, but increases the incidence of vomiting in the first 24 h after surgery."9.07A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children. ( Nicolson, SC; Schreiner, MS; Weinstein, MS, 1994)
"100 male patients aged 60 to 80 years old, a line to elective laparoscopic inguinal hernia repair, were randomly divided into four groups: control group (Group A) and dezocine group (Group B), ketorolac tromethamine group (Group C), ketorolac tromethamine combined with dezocine group (Group D)."5.51Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair. ( Cai, Z; Fu, B; Kang, Y; Li, Y; Wang, J; Wu, Y, 2022)
"Ketorolac or weak opioids are equally effective on acute pain and on persistent postsurgical pain development after IHR, and drug choice should be based on their potential side effects and patient's comorbidities."5.20Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study. ( Allegri, M; Ambrosoli, AL; Braschi, A; Bugada, D; Fanelli, G; Klersy, C; Lavand'homme, P; Saccani Jotti, GM, 2015)
"In this prospective, randomized, double-blinded study we sought to evaluate the efficacy and safety of combined use of intravenous ketorolac and acetaminophen in small children undergoing outpatient inguinal hernia repair."5.14Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children. ( Hong, JY; Kil, HK; Kim, WO; Won Han, S, 2010)
"Diclofenac suppository 50 mg and intravenous ketorolac 30 mg provided equivalent postoperative analgesia following ambulatory inguinal hernia repair under general anaesthesia."5.10Prospective randomized trial of pre-emptive analgesics following ambulatory inguinal hernia repair: intravenous ketorolac versus diclofenac suppository. ( Goh, LC; Lau, H; Lee, F; Patil, NG; Wong, C, 2002)
"For children undergoing inguinal surgery, the administration of a single dose of intravenous morphine after the induction of anesthesia smooths emergence from anesthesia as assessed by improved cooperation and sedation in the PACU, decreases the need for postoperative analgesics, but increases the incidence of vomiting in the first 24 h after surgery."5.07A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children. ( Nicolson, SC; Schreiner, MS; Weinstein, MS, 1994)
"Only a relatively short immediate analgesic benefit could be demonstrated by a combination of IINB with spinal anaesthesia compared with IINB combined with general anaesthesia."2.71Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy. ( Permi, J; Rosenberg, PH; Toivonen, J, 2004)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (36.36)18.2507
2000's2 (18.18)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Wu, Y1
Cai, Z1
Li, Y1
Kang, Y1
Fu, B1
Wang, J1
Bugada, D2
Lavand'homme, P2
Ambrosoli, AL2
Klersy, C1
Braschi, A1
Fanelli, G2
Saccani Jotti, GM2
Allegri, M2
Cappelleri, G1
Meschi, T1
Saryazdi, HH1
Aghadavoudi, O1
Shafa, A1
Masoumi, A1
Saberian, P1
Hong, JY1
Won Han, S1
Kim, WO1
Kil, HK1
Lau, H1
Wong, C1
Goh, LC1
Patil, NG1
Lee, F1
Toivonen, J1
Permi, J1
Rosenberg, PH1
Ben-David, B2
Katz, E1
Gaitini, L2
Goldik, Z2
Twersky, RS1
Lebovits, A1
Williams, C1
Sexton, TR1
Weinstein, MS1
Nicolson, SC1
Schreiner, MS1
Baune-Goldstein, U1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Prospective Study of the Assessment, Prevention and Management of Acute Post-herniotomy Pain[NCT01345162]Phase 4200 participants (Actual)Interventional2010-03-31Completed
Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center,Prospective, Observational Study--The Process Implementation Stage[NCT03761550]480 participants (Actual)Observational2018-12-01Completed
Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center,Prospective, Observational Study--------For the Baseline Investigation and Technical Preparation Stage[NCT03759275]480 participants (Actual)Observational2018-09-01Completed
Ilioinguinal/Iliohypogastric vs. Quadratus Lumborum Nerve Blockade for Elective Open Inguinal Herniorrhaphy[NCT03007966]Phase 260 participants (Actual)Interventional2017-01-30Completed
Effect of Medial vs Traditional Approach to US-guided Transverse Abdominis Plane (TAP) Blocks on Analgesia After Open Inguinal Hernia Repair[NCT01589796]100 participants (Anticipated)Interventional2012-04-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Analgesic Efficacy

"percentage of patients with NRS≥4. (NRS=numeric rating scale; o quantify pain from0=no pain to 10=worst pain possible).~NRS≥4 is cosidered as suboptimal pain control worth to be treated with adjunctive analgesics. We therefore condidered the difference in percentage of patients experiencing not optimal pain control in the two groups to understand, if any, the difference in analgesic efficacy between the two drugs." (NCT01345162)
Timeframe: 4 days postherniotomy

Interventionpercentage of patients with NRS≥4 (Number)
Ketorolac26.5
Acetaminophene + Tramadol32.3

Number of Participants With Presence of Opioid Related Side Effects--Itching

(NCT03007966)
Timeframe: 24 hrs Post Nerve Block

InterventionParticipants (Count of Participants)
Ilioinguinal / Iliohypogastric Block2
Quadratus Lumborum Block3

Number of Participants With Presence of Opioid Related Side Effects--Itching

(NCT03007966)
Timeframe: 8 hrs Post Nerve Block

InterventionParticipants (Count of Participants)
Ilioinguinal / Iliohypogastric Block0
Quadratus Lumborum Block4

Number of Participants With Presence of Opioid Related Side Effects--Nausea

(NCT03007966)
Timeframe: 24 hrs Post Nerve Block

InterventionParticipants (Count of Participants)
Ilioinguinal / Iliohypogastric Block6
Quadratus Lumborum Block3

Number of Participants With Presence of Opioid Related Side Effects--Nausea

(NCT03007966)
Timeframe: 8 hrs Post Nerve Block

InterventionParticipants (Count of Participants)
Ilioinguinal / Iliohypogastric Block9
Quadratus Lumborum Block5

Number of Participants With Presence of Opioid Related Side Effects--Vomiting

(NCT03007966)
Timeframe: 24 hrs Post Nerve Block

InterventionParticipants (Count of Participants)
Ilioinguinal / Iliohypogastric Block3
Quadratus Lumborum Block2

Number of Participants With Presence of Opioid Related Side Effects--Vomiting

(NCT03007966)
Timeframe: 8 hrs Post Nerve Block

InterventionParticipants (Count of Participants)
Ilioinguinal / Iliohypogastric Block3
Quadratus Lumborum Block3

Post-operative Verbal Pain Score at Rest

Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24 hrs Post Nerve Block

Interventionscore on a scale (Mean)
Ilioinguinal / Iliohypogastric Block3
Quadratus Lumborum Block2.7

Post-operative Verbal Pain Score at Rest

Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 8 hrs Post Nerve Block

Interventionscore on a scale (Mean)
Ilioinguinal / Iliohypogastric Block3.6
Quadratus Lumborum Block3.3

Post-operative Verbal Pain Score With Activity

Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24hrs Post Nerve Block

Interventionscore on a scale (Mean)
Ilioinguinal / Iliohypogastric Block4.9
Quadratus Lumborum Block5.3

Post-operative Verbal Pain Score With Movement

Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome. (NCT03007966)
Timeframe: 8 hrs Post Nerve Block

Interventionscore on a scale (Mean)
Ilioinguinal / Iliohypogastric Block5.10
Quadratus Lumborum Block5.03

Time to First Oral Analgesic

When does the patient require their first post operative analgesic dose? (NCT03007966)
Timeframe: 24hrs Post Nerve Block

Interventionminutes (Median)
Ilioinguinal / Iliohypogastric Block141
Quadratus Lumborum Block91

Total Opioid Consumption

Total opioids consumed during the first 24hrs post operatively. Measured as 24hr Oxycodone Equivalent (NCT03007966)
Timeframe: 24 hrs Post Nerve Block

Interventionmilligrams (Mean)
Ilioinguinal / Iliohypogastric Block19.7
Quadratus Lumborum Block25.2

Trials

10 trials available for ketorolac and Inguinal Hernia

ArticleYear
Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair.
    Medicine, 2022, May-20, Volume: 101, Issue:20

    Topics: Aged; Aged, 80 and over; Analgesia; Bridged Bicyclo Compounds, Heterocyclic; Hemodynamics; Hernia, I

2022
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:8

    Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain;

2015
A COMPARATIVE STUDY OF THE ANALGESIC EFFECT OF INTRAVENOUS PETHIDINE VS. KETOROLAC AFTER INGUINAL HERNIA SURGERY IN CHILDREN UNDER GENERAL ANESTHESIA.
    Middle East journal of anaesthesiology, 2016, Volume: 23, Issue:5

    Topics: Analgesics; Anesthesia, General; Child; Child, Preschool; Double-Blind Method; Female; Hernia, Ingui

2016
Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children.
    The Journal of urology, 2010, Volume: 183, Issue:4

    Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In

2010
Prospective randomized trial of pre-emptive analgesics following ambulatory inguinal hernia repair: intravenous ketorolac versus diclofenac suppository.
    ANZ journal of surgery, 2002, Volume: 72, Issue:10

    Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anti-Inflammatory Agents, Non-Steroidal; Ch

2002
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:4

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane

2004
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:4

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane

2004
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:4

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane

2004
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:4

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane

2004
Comparison of i.m. and local infiltration of ketorolac with and without local anaesthetic.
    British journal of anaesthesia, 1995, Volume: 75, Issue:4

    Topics: Administration, Topical; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Local

1995
Ketorolac versus fentanyl for postoperative pain management in outpatients.
    The Clinical journal of pain, 1995, Volume: 11, Issue:2

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Arthroscopy; Double-Blind Method; F

1995
A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children.
    Anesthesiology, 1994, Volume: 81, Issue:3

    Topics: Age Factors; Ambulatory Surgical Procedures; Analgesics; Child; Child, Preschool; Double-Blind Metho

1994
Is preoperative ketorolac a useful adjunct to regional anesthesia for inguinal herniorrhaphy?
    Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:3

    Topics: Adjuvants, Anesthesia; Administration, Oral; Ambulatory Surgical Procedures; Analgesics, Non-Narcoti

1996

Other Studies

1 other study available for ketorolac and Inguinal Hernia

ArticleYear
Effect of Preoperative Inflammatory Status and Comorbidities on Pain Resolution and Persistent Postsurgical Pain after Inguinal Hernia Repair.
    Mediators of inflammation, 2016, Volume: 2016

    Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pai

2016