ketorolac has been researched along with Inguinal Hernia in 11 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this prospective, randomized, double-blinded study we sought to evaluate the efficacy and safety of combined use of intravenous ketorolac and acetaminophen in small children undergoing outpatient inguinal hernia repair." | 9.14 | Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children. ( Hong, JY; Kil, HK; Kim, WO; Won Han, S, 2010) |
| "Diclofenac suppository 50 mg and intravenous ketorolac 30 mg provided equivalent postoperative analgesia following ambulatory inguinal hernia repair under general anaesthesia." | 9.10 | Prospective randomized trial of pre-emptive analgesics following ambulatory inguinal hernia repair: intravenous ketorolac versus diclofenac suppository. ( Goh, LC; Lau, H; Lee, F; Patil, NG; Wong, C, 2002) |
| "For children undergoing inguinal surgery, the administration of a single dose of intravenous morphine after the induction of anesthesia smooths emergence from anesthesia as assessed by improved cooperation and sedation in the PACU, decreases the need for postoperative analgesics, but increases the incidence of vomiting in the first 24 h after surgery." | 9.07 | A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children. ( Nicolson, SC; Schreiner, MS; Weinstein, MS, 1994) |
| "100 male patients aged 60 to 80 years old, a line to elective laparoscopic inguinal hernia repair, were randomly divided into four groups: control group (Group A) and dezocine group (Group B), ketorolac tromethamine group (Group C), ketorolac tromethamine combined with dezocine group (Group D)." | 5.51 | Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair. ( Cai, Z; Fu, B; Kang, Y; Li, Y; Wang, J; Wu, Y, 2022) |
| "Ketorolac or weak opioids are equally effective on acute pain and on persistent postsurgical pain development after IHR, and drug choice should be based on their potential side effects and patient's comorbidities." | 5.20 | Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study. ( Allegri, M; Ambrosoli, AL; Braschi, A; Bugada, D; Fanelli, G; Klersy, C; Lavand'homme, P; Saccani Jotti, GM, 2015) |
| "In this prospective, randomized, double-blinded study we sought to evaluate the efficacy and safety of combined use of intravenous ketorolac and acetaminophen in small children undergoing outpatient inguinal hernia repair." | 5.14 | Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children. ( Hong, JY; Kil, HK; Kim, WO; Won Han, S, 2010) |
| "Diclofenac suppository 50 mg and intravenous ketorolac 30 mg provided equivalent postoperative analgesia following ambulatory inguinal hernia repair under general anaesthesia." | 5.10 | Prospective randomized trial of pre-emptive analgesics following ambulatory inguinal hernia repair: intravenous ketorolac versus diclofenac suppository. ( Goh, LC; Lau, H; Lee, F; Patil, NG; Wong, C, 2002) |
| "For children undergoing inguinal surgery, the administration of a single dose of intravenous morphine after the induction of anesthesia smooths emergence from anesthesia as assessed by improved cooperation and sedation in the PACU, decreases the need for postoperative analgesics, but increases the incidence of vomiting in the first 24 h after surgery." | 5.07 | A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children. ( Nicolson, SC; Schreiner, MS; Weinstein, MS, 1994) |
| "Only a relatively short immediate analgesic benefit could be demonstrated by a combination of IINB with spinal anaesthesia compared with IINB combined with general anaesthesia." | 2.71 | Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy. ( Permi, J; Rosenberg, PH; Toivonen, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, Y | 1 |
| Cai, Z | 1 |
| Li, Y | 1 |
| Kang, Y | 1 |
| Fu, B | 1 |
| Wang, J | 1 |
| Bugada, D | 2 |
| Lavand'homme, P | 2 |
| Ambrosoli, AL | 2 |
| Klersy, C | 1 |
| Braschi, A | 1 |
| Fanelli, G | 2 |
| Saccani Jotti, GM | 2 |
| Allegri, M | 2 |
| Cappelleri, G | 1 |
| Meschi, T | 1 |
| Saryazdi, HH | 1 |
| Aghadavoudi, O | 1 |
| Shafa, A | 1 |
| Masoumi, A | 1 |
| Saberian, P | 1 |
| Hong, JY | 1 |
| Won Han, S | 1 |
| Kim, WO | 1 |
| Kil, HK | 1 |
| Lau, H | 1 |
| Wong, C | 1 |
| Goh, LC | 1 |
| Patil, NG | 1 |
| Lee, F | 1 |
| Toivonen, J | 1 |
| Permi, J | 1 |
| Rosenberg, PH | 1 |
| Ben-David, B | 2 |
| Katz, E | 1 |
| Gaitini, L | 2 |
| Goldik, Z | 2 |
| Twersky, RS | 1 |
| Lebovits, A | 1 |
| Williams, C | 1 |
| Sexton, TR | 1 |
| Weinstein, MS | 1 |
| Nicolson, SC | 1 |
| Schreiner, MS | 1 |
| Baune-Goldstein, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Prospective Study of the Assessment, Prevention and Management of Acute Post-herniotomy Pain[NCT01345162] | Phase 4 | 200 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center，Prospective, Observational Study--The Process Implementation Stage[NCT03761550] | 480 participants (Actual) | Observational | 2018-12-01 | Completed | |||
| Perioperative Pain Management With Multi-discipline Team(pMDT) in Thoracic Surgery: a Multi-center，Prospective, Observational Study--------For the Baseline Investigation and Technical Preparation Stage[NCT03759275] | 480 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| Ilioinguinal/Iliohypogastric vs. Quadratus Lumborum Nerve Blockade for Elective Open Inguinal Herniorrhaphy[NCT03007966] | Phase 2 | 60 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Effect of Medial vs Traditional Approach to US-guided Transverse Abdominis Plane (TAP) Blocks on Analgesia After Open Inguinal Hernia Repair[NCT01589796] | 100 participants (Anticipated) | Interventional | 2012-04-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"percentage of patients with NRS≥4. (NRS=numeric rating scale; o quantify pain from0=no pain to 10=worst pain possible).~NRS≥4 is cosidered as suboptimal pain control worth to be treated with adjunctive analgesics. We therefore condidered the difference in percentage of patients experiencing not optimal pain control in the two groups to understand, if any, the difference in analgesic efficacy between the two drugs." (NCT01345162)
Timeframe: 4 days postherniotomy
| Intervention | percentage of patients with NRS≥4 (Number) |
|---|---|
| Ketorolac | 26.5 |
| Acetaminophene + Tramadol | 32.3 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 2 |
| Quadratus Lumborum Block | 3 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 0 |
| Quadratus Lumborum Block | 4 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 6 |
| Quadratus Lumborum Block | 3 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 9 |
| Quadratus Lumborum Block | 5 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 3 |
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2.7 |
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3.6 |
| Quadratus Lumborum Block | 3.3 |
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 4.9 |
| Quadratus Lumborum Block | 5.3 |
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome. (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 5.10 |
| Quadratus Lumborum Block | 5.03 |
When does the patient require their first post operative analgesic dose? (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | minutes (Median) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 141 |
| Quadratus Lumborum Block | 91 |
Total opioids consumed during the first 24hrs post operatively. Measured as 24hr Oxycodone Equivalent (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | milligrams (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 19.7 |
| Quadratus Lumborum Block | 25.2 |
10 trials available for ketorolac and Inguinal Hernia
| Article | Year |
|---|---|
Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair.
Topics: Aged; Aged, 80 and over; Analgesia; Bridged Bicyclo Compounds, Heterocyclic; Hemodynamics; Hernia, I | 2022 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study.
Topics: Acute Pain; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; | 2015 |
A COMPARATIVE STUDY OF THE ANALGESIC EFFECT OF INTRAVENOUS PETHIDINE VS. KETOROLAC AFTER INGUINAL HERNIA SURGERY IN CHILDREN UNDER GENERAL ANESTHESIA.
Topics: Analgesics; Anesthesia, General; Child; Child, Preschool; Double-Blind Method; Female; Hernia, Ingui | 2016 |
Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In | 2010 |
Prospective randomized trial of pre-emptive analgesics following ambulatory inguinal hernia repair: intravenous ketorolac versus diclofenac suppository.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anti-Inflammatory Agents, Non-Steroidal; Ch | 2002 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Comparison of i.m. and local infiltration of ketorolac with and without local anaesthetic.
Topics: Administration, Topical; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Local | 1995 |
Ketorolac versus fentanyl for postoperative pain management in outpatients.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Arthroscopy; Double-Blind Method; F | 1995 |
A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children.
Topics: Age Factors; Ambulatory Surgical Procedures; Analgesics; Child; Child, Preschool; Double-Blind Metho | 1994 |
Is preoperative ketorolac a useful adjunct to regional anesthesia for inguinal herniorrhaphy?
Topics: Adjuvants, Anesthesia; Administration, Oral; Ambulatory Surgical Procedures; Analgesics, Non-Narcoti | 1996 |
1 other study available for ketorolac and Inguinal Hernia
| Article | Year |
|---|---|
Effect of Preoperative Inflammatory Status and Comorbidities on Pain Resolution and Persistent Postsurgical Pain after Inguinal Hernia Repair.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pai | 2016 |