ketorolac has been researched along with Inflammation in 41 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0." | 9.20 | The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery. ( Chung, BH; Jung, JW; Kim, EK; Kim, TI; Seo, KY, 2015) |
| "As a new ophthalmic non-steroidal anti-inflammatory drug (NSAID) with prodrug structure, Nepafenac was supposed to have a better efficacy than conventional NSAIDs both in patients' tolerability and ocular inflammation associated with cataract surgery." | 8.95 | Comparison of the efficacy and patients' tolerability of Nepafenac and Ketorolac in the treatment of ocular inflammation following cataract surgery: A meta-analysis of randomized controlled trials. ( Chen, Y; Wang, E; Xia, S; Zhao, X, 2017) |
| " Present studies examine effects of the nonsteroidal anti-inflammatory drug, ketorolac, upon RV inflammation and dysfunction." | 7.75 | Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats. ( Gellar, MA; Kline, JA; Obraztsova, M; Stuart, LK; Watts, JA, 2009) |
| "We previously reported that partial sciatic nerve ligation (PSNL) dramatically up-regulates cyclooxygenase 2 (COX2) in injured sciatic nerve, and local injection of the COX inhibitor, ketorolac, reverses tactile allodynia and suppresses increased phosphorylation of the transcription factor cAMP responsive element binding protein [Eur J Neurosci 15 (2002) 1037]." | 7.72 | Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. ( Eisenach, JC; Ma, W, 2003) |
| "Ketorolac is an effective non-steroidal anti-inflammatory drug, commonly used with local anaesthetics as part of local infiltration analgesia protocols following orthopaedic surgery." | 6.87 | Randomized controlled trial of intra-articular ketorolac on pain and inflammation after minor arthroscopic knee surgery. ( Bjerkeli, V; Gordh, T; Gregersen, I; Halvorsen, B; Rosseland, LA; Solheim, N; Stubhaug, A, 2018) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s." | 6.50 | Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014) |
| "Treatment with morphine (1mg/kg, s." | 5.38 | Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac. ( Fujita, I; Kita, Y; Okumura, T; Sakakibara, A, 2012) |
| "A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0." | 5.20 | The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery. ( Chung, BH; Jung, JW; Kim, EK; Kim, TI; Seo, KY, 2015) |
| " The aim was to explore the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg administered intravenously on experimental pain models in human beings." | 5.15 | A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K; Salomon, D, 2011) |
| "As a new ophthalmic non-steroidal anti-inflammatory drug (NSAID) with prodrug structure, Nepafenac was supposed to have a better efficacy than conventional NSAIDs both in patients' tolerability and ocular inflammation associated with cataract surgery." | 4.95 | Comparison of the efficacy and patients' tolerability of Nepafenac and Ketorolac in the treatment of ocular inflammation following cataract surgery: A meta-analysis of randomized controlled trials. ( Chen, Y; Wang, E; Xia, S; Zhao, X, 2017) |
| "Focusing on a high-risk group with preoperative inflammation could lead to a clinical trial to test the effect of ketorolac on cancer outcome." | 4.90 | Perspectives in anaesthesia for cancer surgery. ( De Kock, M; Forget, P, 2014) |
| " Our aim was, for the first time, to analyze the morpho-functional effects of postoperative administration of two commonly used NSAIDs, Diclofenac and Ketorolac, on the healing process of colo-colic anastomoses constructed under condition of fecal peritonitis in a rat model." | 3.96 | Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration. ( Casciani, F; Ghiselli, R; Guerrieri, M; Lucarini, G; Orlando, F; Ortenzi, M; Provinciali, M; Saccomanno, S; Salvolini, E, 2020) |
| "Although PRP and ketorolac reduced cellular inflammation markers (E-selectin, vascular cell adhesion molecule, and human leukocyte antigen DR) compared with control, neither caused as great a reduction as methylprednisolone." | 3.79 | An in vitro evaluation of the anti-inflammatory effects of platelet-rich plasma, ketorolac, and methylprednisolone. ( Apostolakos, J; Arciero, RA; Beitzel, K; Bradley, J; Cote, MP; Intravia, J; Mazzocca, AD; McCarthy, MB, 2013) |
| " Present studies examine effects of the nonsteroidal anti-inflammatory drug, ketorolac, upon RV inflammation and dysfunction." | 3.75 | Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats. ( Gellar, MA; Kline, JA; Obraztsova, M; Stuart, LK; Watts, JA, 2009) |
| "We previously reported that partial sciatic nerve ligation (PSNL) dramatically up-regulates cyclooxygenase 2 (COX2) in injured sciatic nerve, and local injection of the COX inhibitor, ketorolac, reverses tactile allodynia and suppresses increased phosphorylation of the transcription factor cAMP responsive element binding protein [Eur J Neurosci 15 (2002) 1037]." | 3.72 | Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. ( Eisenach, JC; Ma, W, 2003) |
| " Local injection of ketorolac, a nonselective COX inhibitor, into the ipsilateral plantar side or into the injury site of the sciatic nerve, effectively reversed the tactile allodynia induced by PSNL for > 5 days." | 3.71 | Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. ( Eisenach, JC; Ma, W, 2002) |
| "Ketorolac is an effective non-steroidal anti-inflammatory drug, commonly used with local anaesthetics as part of local infiltration analgesia protocols following orthopaedic surgery." | 2.87 | Randomized controlled trial of intra-articular ketorolac on pain and inflammation after minor arthroscopic knee surgery. ( Bjerkeli, V; Gordh, T; Gregersen, I; Halvorsen, B; Rosseland, LA; Solheim, N; Stubhaug, A, 2018) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s." | 2.50 | Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014) |
| "Most relapses in breast cancer are in the early category." | 2.49 | Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review. ( Baum, M; De Kock, M; Demicheli, R; Forget, P; Gukas, I; Hrushesky, WJ; Retsky, M; Rogers, RA; Sukhatme, V; Vaidya, JS, 2013) |
| "The initiation time of myoclonic seizures (ITMS), the initiation time of tonic-clonic seizures (ITTS), seizure duration (SD), and mortality rate (MR) were measured for 30 min." | 1.91 | Effects of Intracerebroventricular Injection of the Steroidal and Non-Steroidal Anti-Inflammatory Drugs on the Seizures during the Estrous Cycle in Rat. ( Fazlelahi, Z; Kaboutari, J; Panahi, N; Zendehdel, M, 2023) |
| "Ocular inflammation was induced where after the ocular coil was inserted, or eye drops, or no treatment was provided." | 1.62 | Pharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits. ( Bertens, CJF; Dias, AAJ; Ghosh, A; Gijs, M; Nuijts, RMMA; Sethu, S; van den Biggelaar, FJHM, 2021) |
| "This may also explain sudden confusion and dementia for the elderly after surgery." | 1.48 | Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly: An Unexpected Connection but with the Same Proposed Solution. ( Forget, P; Retsky, MW, 2018) |
| "Treatment with morphine (1mg/kg, s." | 1.38 | Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac. ( Fujita, I; Kita, Y; Okumura, T; Sakakibara, A, 2012) |
| "Paw inflammation was induced with 3% carrageenan and was measured with a plethysmometer at 30 minutes and 4, 8, and 24 hours after intraperitoneal injection." | 1.36 | Evaluation of the anti-inflammatory effects of ellagic acid. ( Corbett, S; Daniel, J; Drayton, R; Field, M; Garrett, N; Steinhardt, R, 2010) |
| "Ketorolac is a non-steroidal anti-inflammatory drug." | 1.34 | Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation. ( Chaturvedi, SC; Trivedi, P; Vyas, S, 2007) |
| " Footpad PG levels returned to base line or below within 5 min of dosing with ketorolac, which suggests rapid turnover of PG in the inflamed tissue." | 1.30 | Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. ( Isakson, PC; Portanova, J; Seibert, K; Shaffer, A; Zhang, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.44) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 15 (36.59) | 29.6817 |
| 2010's | 20 (48.78) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Muchowski, JM | 1 |
| Galeazzi, E | 1 |
| Greenhouse, R | 1 |
| Guzmán, A | 1 |
| Peréz, V | 1 |
| Ackerman, N | 1 |
| Ballaron, SA | 1 |
| Rovito, JR | 1 |
| Tomolonis, AJ | 1 |
| Young, JM | 1 |
| Martínez-Martínez, MDC | 1 |
| Parra-Flores, LI | 1 |
| Baeza-Flores, GDC | 1 |
| Torres-López, JE | 1 |
| Fazlelahi, Z | 1 |
| Kaboutari, J | 1 |
| Zendehdel, M | 1 |
| Panahi, N | 1 |
| Ghiselli, R | 1 |
| Lucarini, G | 1 |
| Ortenzi, M | 1 |
| Salvolini, E | 1 |
| Saccomanno, S | 1 |
| Orlando, F | 1 |
| Provinciali, M | 1 |
| Casciani, F | 1 |
| Guerrieri, M | 1 |
| Bertens, CJF | 1 |
| Gijs, M | 1 |
| Dias, AAJ | 1 |
| van den Biggelaar, FJHM | 1 |
| Ghosh, A | 1 |
| Sethu, S | 1 |
| Nuijts, RMMA | 1 |
| Kuchálik, J | 1 |
| Magnuson, A | 1 |
| Tina, E | 1 |
| Gupta, A | 1 |
| Solheim, N | 1 |
| Gregersen, I | 1 |
| Halvorsen, B | 1 |
| Bjerkeli, V | 1 |
| Stubhaug, A | 1 |
| Gordh, T | 1 |
| Rosseland, LA | 1 |
| Wu, PC | 1 |
| Shieh, DB | 1 |
| Hsiao, HT | 2 |
| Wang, JC | 1 |
| Lin, YC | 1 |
| Liu, YC | 1 |
| Matava, MJ | 1 |
| Retsky, MW | 1 |
| Forget, P | 4 |
| Hirsch, S | 1 |
| Corradini, L | 1 |
| Just, S | 1 |
| Arndt, K | 1 |
| Doods, H | 1 |
| Berlière, M | 1 |
| van Maanen, A | 1 |
| Duhoux, FP | 1 |
| Machiels, JP | 1 |
| Coulie, PG | 1 |
| Bouche, G | 1 |
| De Kock, M | 3 |
| Retsky, M | 1 |
| Demicheli, R | 1 |
| Hrushesky, WJ | 1 |
| Gukas, I | 1 |
| Rogers, RA | 1 |
| Baum, M | 1 |
| Sukhatme, V | 1 |
| Vaidya, JS | 1 |
| Nalamachu, S | 1 |
| Wortmann, R | 1 |
| Jung, JW | 1 |
| Chung, BH | 1 |
| Kim, EK | 1 |
| Seo, KY | 1 |
| Kim, TI | 1 |
| Ganapathy, PS | 1 |
| Lowder, CY | 1 |
| Srivastava, SK | 1 |
| Zhao, X | 1 |
| Xia, S | 1 |
| Wang, E | 1 |
| Chen, Y | 1 |
| Scarlett, JM | 1 |
| Zhu, X | 1 |
| Enriori, PJ | 1 |
| Bowe, DD | 1 |
| Batra, AK | 1 |
| Levasseur, PR | 1 |
| Grant, WF | 1 |
| Meguid, MM | 1 |
| Cowley, MA | 1 |
| Marks, DL | 1 |
| Watts, JA | 1 |
| Gellar, MA | 1 |
| Stuart, LK | 1 |
| Obraztsova, M | 1 |
| Kline, JA | 1 |
| Hamza, M | 2 |
| Wang, XM | 2 |
| Adam, A | 1 |
| Brahim, JS | 2 |
| Rowan, JS | 2 |
| Carmona, GN | 1 |
| Dionne, RA | 2 |
| Corbett, S | 1 |
| Daniel, J | 1 |
| Drayton, R | 1 |
| Field, M | 1 |
| Steinhardt, R | 1 |
| Garrett, N | 1 |
| Wu, T | 1 |
| Sokolov, AY | 1 |
| Lyubashina, OA | 1 |
| Panteleev, SS | 1 |
| Chizh, BA | 1 |
| Ing Lorenzini, K | 1 |
| Besson, M | 1 |
| Daali, Y | 1 |
| Salomon, D | 1 |
| Dayer, P | 1 |
| Desmeules, J | 1 |
| Fujita, I | 1 |
| Okumura, T | 1 |
| Sakakibara, A | 1 |
| Kita, Y | 1 |
| Mazzocca, AD | 1 |
| McCarthy, MB | 1 |
| Intravia, J | 1 |
| Beitzel, K | 1 |
| Apostolakos, J | 1 |
| Cote, MP | 1 |
| Bradley, J | 1 |
| Arciero, RA | 1 |
| Blais, V | 2 |
| Zhang, J | 1 |
| Rivest, S | 2 |
| Ma, W | 2 |
| Eisenach, JC | 2 |
| Yaksh, TL | 1 |
| Horais, KA | 1 |
| Tozier, N | 1 |
| Rathbun, M | 1 |
| Richter, P | 1 |
| Rossi, S | 1 |
| Grafe, M | 1 |
| Tong, C | 1 |
| Meschter, C | 1 |
| Cline, JM | 1 |
| Eisenach, J | 1 |
| Hsueh, SF | 1 |
| Lu, CY | 1 |
| Chao, CS | 1 |
| Tan, PH | 1 |
| Huang, YW | 1 |
| Hsieh, SW | 1 |
| Chung, NC | 1 |
| Lin, SH | 1 |
| Huang, PL | 1 |
| Lyu, PC | 1 |
| Yang, LC | 1 |
| Dogan, N | 1 |
| Erdem, AF | 1 |
| Gundogdu, C | 1 |
| Kursad, H | 1 |
| Kizilkaya, M | 1 |
| Turrin, NP | 1 |
| Vyas, S | 1 |
| Trivedi, P | 1 |
| Chaturvedi, SC | 1 |
| Zhang, Y | 1 |
| Shaffer, A | 1 |
| Portanova, J | 1 |
| Seibert, K | 1 |
| Isakson, PC | 1 |
| Hong, SH | 1 |
| Ondrey, FG | 1 |
| Avis, IM | 1 |
| Chen, Z | 1 |
| Loukinova, E | 1 |
| Cavanaugh, PF | 1 |
| Van Waes, C | 1 |
| Mulshine, JL | 1 |
| Junger, H | 1 |
| Sorkin, LS | 1 |
| Gupta, AK | 1 |
| Madan, S | 1 |
| Majumdar, DK | 1 |
| Maitra, A | 1 |
| Du Manoir, B | 1 |
| Fletcher, D | 1 |
| Al-Samsam, T | 1 |
| Chelly, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Perioperative Ketorolac in High Risk Breast Cancer Patients With and Without Inflammation. A Prospective Randomized Placebo-controlled Trial.[NCT01806259] | Phase 3 | 203 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections: a Prospective Double-Blinded Randomized Trial[NCT04895280] | Phase 4 | 400 participants (Anticipated) | Interventional | 2024-04-30 | Not yet recruiting | ||
| Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial[NCT04115644] | Phase 4 | 82 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Covid-19 and we failed to submit annual report for 2017 and 2018) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 years for the primary analysis + 3 additional years for secondary analysis (From date of randomization until the date of death from any cause assessed up to 5 years) (NCT01806259)
Timeframe: 5 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketorolac 30 mg | 93 |
| NaCl 0.9% 3mL | 105 |
2 years for the primary analysis + 3 additional years for secondary analysis (From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 5 years) (NCT01806259)
Timeframe: 5 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketorolac 30 mg | 80 |
| NaCl 0.9% 3mL | 96 |
Pain as measured by the Visual Analog Scale after first injection. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Baseline - immediately after the injection
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.197 |
| Group 2 (Ketorolac) | 3.577 |
| Group 3 (Kenalog) | 3.677 |
Pain as measured by the Visual Analog Scale prior to first injection. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Baseline - pre-injection
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 5.77 |
| Group 2 (Ketorolac) | 4.57 |
| Group 3 (Kenalog) | 4.67 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Day 2
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 2.347 |
| Group 2 (Ketorolac) | 2.837 |
| Group 3 (Kenalog) | 2.67 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 1
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.397 |
| Group 2 (Ketorolac) | 3.7 |
| Group 3 (Kenalog) | 3.257 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 12
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.447 |
| Group 2 (Ketorolac) | 1.417 |
| Group 3 (Kenalog) | 2.027 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 2
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.547 |
| Group 2 (Ketorolac) | 2.67 |
| Group 3 (Kenalog) | 2.57 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 4
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.547 |
| Group 2 (Ketorolac) | 2.67 |
| Group 3 (Kenalog) | 2.317 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 6
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.357 |
| Group 2 (Ketorolac) | 2.757 |
| Group 3 (Kenalog) | 2.687 |
5 reviews available for ketorolac and Inflammation
| Article | Year |
|---|---|
Injectable Nonsteroidal Anti-Inflammatory Drugs in Sport.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Athletes; Athletic Injuries; Humans; Inflammation; Injectio | 2018 |
Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Computer Simulation; Disease-Free Surviva | 2013 |
Perspectives in anaesthesia for cancer surgery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Breast Neoplasms; Clinical Trials as Topic; Fem | 2014 |
Role of indomethacin in acute pain and inflammation management: a review of the literature.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Inflammation; Ketorolac; | 2014 |
Comparison of the efficacy and patients' tolerability of Nepafenac and Ketorolac in the treatment of ocular inflammation following cataract surgery: A meta-analysis of randomized controlled trials.
Topics: Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Cataract Extraction; H | 2017 |
6 trials available for ketorolac and Inflammation
| Article | Year |
|---|---|
Does local infiltration analgesia reduce peri-operative inflammation following total hip arthroplasty? A randomized, double-blind study.
Topics: Amides; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; | 2017 |
Randomized controlled trial of intra-articular ketorolac on pain and inflammation after minor arthroscopic knee surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Cells, Cultured; Female; Humans; Inflam | 2018 |
Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Female; Humans; Inflammation; Ketorolac; | 2013 |
The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Cataract; Cataract Extr | 2015 |
Nitric oxide is negatively correlated to pain during acute inflammation.
Topics: Acute Disease; Adolescent; Adult; Female; Gene Expression Regulation, Enzymologic; Humans; Inflammat | 2010 |
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cross-Over | 2011 |
30 other studies available for ketorolac and Inflammation
| Article | Year |
|---|---|
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenom | 1989 |
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr | 2022 |
Effects of Intracerebroventricular Injection of the Steroidal and Non-Steroidal Anti-Inflammatory Drugs on the Seizures during the Estrous Cycle in Rat.
Topics: Animals; Anti-Inflammatory Agents; Estrous Cycle; Female; Inflammation; Ketorolac; Methylprednisolon | 2023 |
Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Di | 2020 |
Pharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Drug Delivery Systems; Eye; Female; | 2021 |
Magnetic field distribution modulation of intrathecal delivered ketorolac iron-oxide nanoparticle conjugates produce excellent analgesia for chronic inflammatory pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Inflammation; Injections, Spinal; Ketorolac; Magne | 2018 |
Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly: An Unexpected Connection but with the Same Proposed Solution.
Topics: Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Confusi | 2018 |
The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behav | 2013 |
Aggressive Initial Presentation of HLA-B27 Uveitis in Older Individuals: A Case Series.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Glucocorticoids; HLA-B27 A | 2018 |
Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
Topics: Agouti-Related Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arcuate Nucleus of Hypotha | 2008 |
Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Cyclooxygenase 2; Cyclooxygenase | 2009 |
Kinin B1 receptors contributes to acute pain following minor surgery in humans.
Topics: Acute Disease; Adolescent; Adult; Bradykinin; Cyclooxygenase Inhibitors; Down-Regulation; Female; Ge | 2010 |
Evaluation of the anti-inflammatory effects of ellagic acid.
Topics: Anesthetics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; | 2010 |
Neurophysiological markers of central sensitisation in the trigeminal pathway and their modulation by the cyclo-oxygenase inhibitor ketorolac.
Topics: Animals; Biomarkers; Cyclooxygenase Inhibitors; Disease Models, Animal; Dura Mater; Electric Stimula | 2010 |
Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Hyperalgesia; | 2012 |
An in vitro evaluation of the anti-inflammatory effects of platelet-rich plasma, ketorolac, and methylprednisolone.
Topics: Adult; Anti-Inflammatory Agents; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; In | 2013 |
In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain.
Topics: Adrenal Glands; Animals; Brain; Chemokine CCL2; Corticosterone; Cyclooxygenase 2; Cyclooxygenase 2 I | 2002 |
Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Carrageenan; Cell Count; Cyclooxygenase | 2003 |
Intrathecal ketorolac in dogs and rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Dogs; Dose-Response Relationship, Dru | 2004 |
Nonsteroidal anti-inflammatory drugs increase expression of inducible COX-2 isoform of cyclooxygenase in spinal cord of rats with adjuvant induced inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2004 |
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma | 2004 |
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma | 2004 |
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma | 2004 |
The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Inflamma | 2004 |
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.
Topics: Animals; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase I | 2005 |
Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Carrag | 2007 |
Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Hyperalgesia; Inflammation; Ketorolac; Male; Rats; | 1997 |
Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation?
Topics: Animals; Antibodies; Arachidonic Acid; Cell Division; Clinical Trials, Phase II as Topic; Culture Me | 2000 |
Isoprostanes induce plasma extravasation in rat skin.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Evans Blue; Extravasation of Diagnostic | 2000 |
Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies.
Topics: Acrylamides; Acrylates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Excipients; | 2000 |
Preemptive analgesic effect or short delay for inflammation?
Topics: Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Ketorolac; Pain Measu | 2002 |
Is the administration of ketorolac associated with preemptive analgesia?
Topics: Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Ketorolac; Pain Measu | 2002 |
Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2002 |