ketorolac has been researched along with Inflammation, Endodontic in 13 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis." | 9.69 | Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023) |
| "The purpose of this randomized, double-blind study was to evaluate the anesthetic efficacy of lidocaine-ketorolac administration by Inferior Alveolar Nerve Block (IANB) in patients with irreversible pulpitis." | 9.34 | Anesthetic Efficacy of Lidocaine/Ketorolac in Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Randomized Clinical Trial. ( Aggarwal, V; Faghihian, H; Faghihian, R; Khademi, A, 2020) |
| "Previous studies in patients with irreversible pulpitis have reported increased success of the inferior alveolar nerve block (IANB) using premedication with ketorolac." | 9.27 | Effect of a Combination of Intranasal Ketorolac and Nitrous Oxide on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Study. ( Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Stentz, D, 2018) |
| "The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine whether ketorolac buccal infiltrations (BIs) helped to improve the success of inferior alveolar nerve blocks (IANBs) in patients with acute irreversible pulpitis (AIP)." | 9.22 | Efficacy of Ketorolac Buccal Infiltrations and Inferior Alveolar Nerve Blocks in Patients with Irreversible Pulpitis: A Prospective, Double-blind, Randomized Clinical Trial. ( Abbott, PV; Akhlaghi, NM; Hormozi, B; Khalilak, Z, 2016) |
| "Preoperative administration of ibuprofen or ketorolac has no significant effect on success rate of inferior alveolar nerve block in patients with irreversible pulpitis." | 9.14 | Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical tri ( Aggarwal, V; Kabi, D; Singla, M, 2010) |
| "To examine whether an intra-oral injection of a nonsteroidal anti-inflammatory drug (ketorolac), in association with conventional local anaesthetic techniques, would improve the pulp extirpation rate in teeth with irreversible pulpitis." | 9.11 | The use of an intra-oral injection of ketorolac in the treatment of irreversible pulpitis. ( Dorman, ML; Girdler, NM; Mellor, AC, 2005) |
| "The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis." | 5.69 | Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023) |
| "This randomized double-blinded trial aimed to compare the anesthetic success of inferior alveolar nerve blocks (IANBs) with 2% lidocaine in mandibular molars with symptomatic irreversible pulpitis (SIP) after oral premedication of prednisolone, dexamethasone, and ketorolac with placebo." | 5.69 | Effect of Preoperative Oral Steroids in Comparison to Anti-inflammatory on Anesthetic Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis-A Double-blinded Randomized Clinical Trial. ( Hegde, V; Kulkarni, V; Nagendrababu, V; Setzer, FC; Shaikh, S; Shanmugasundaram, S; Suresh, N, 2023) |
| "The purpose of this randomized, double-blind study was to evaluate the anesthetic efficacy of lidocaine-ketorolac administration by Inferior Alveolar Nerve Block (IANB) in patients with irreversible pulpitis." | 5.34 | Anesthetic Efficacy of Lidocaine/Ketorolac in Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Randomized Clinical Trial. ( Aggarwal, V; Faghihian, H; Faghihian, R; Khademi, A, 2020) |
| " The purpose of this study was to compare the efficacy of intranasal ketorolac (Sprix; Egalet US Inc, Wayne, PA) with a combination of ibuprofen/acetaminophen in an acute pain model of untreated endodontic patients experiencing moderate to severe pain and symptomatic apical periodontitis." | 5.30 | Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation. ( Balzer, S; Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Watts, K, 2019) |
| "The aim of the present double-blind, randomized, controlled clinical trial was to evaluate the effect of ketorolac buccal infiltration of on postendodontic pain of patients with symptomatic irreversible pulpitis in mandibular first/second molars." | 5.30 | The effect of ketorolac buccal infiltration on postoperative endodontic pain: a prospective, double-blind, randomized, controlled clinical trial. ( Akhlaghi, N; Akhoundi, N; Azarshab, M; Meraji, N, 2019) |
| "Previous studies in patients with irreversible pulpitis have reported increased success of the inferior alveolar nerve block (IANB) using premedication with ketorolac." | 5.27 | Effect of a Combination of Intranasal Ketorolac and Nitrous Oxide on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Study. ( Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Stentz, D, 2018) |
| "The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine whether ketorolac buccal infiltrations (BIs) helped to improve the success of inferior alveolar nerve blocks (IANBs) in patients with acute irreversible pulpitis (AIP)." | 5.22 | Efficacy of Ketorolac Buccal Infiltrations and Inferior Alveolar Nerve Blocks in Patients with Irreversible Pulpitis: A Prospective, Double-blind, Randomized Clinical Trial. ( Abbott, PV; Akhlaghi, NM; Hormozi, B; Khalilak, Z, 2016) |
| "Preoperative administration of ibuprofen or ketorolac has no significant effect on success rate of inferior alveolar nerve block in patients with irreversible pulpitis." | 5.14 | Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical tri ( Aggarwal, V; Kabi, D; Singla, M, 2010) |
| "To examine whether an intra-oral injection of a nonsteroidal anti-inflammatory drug (ketorolac), in association with conventional local anaesthetic techniques, would improve the pulp extirpation rate in teeth with irreversible pulpitis." | 5.11 | The use of an intra-oral injection of ketorolac in the treatment of irreversible pulpitis. ( Dorman, ML; Girdler, NM; Mellor, AC, 2005) |
| " Pain levels were also recorded at 15 and 30 minutes after the initial IN dosing (before endodontic treatment); 30 minutes after completion of endodontic treatment; and 4, 8, and 12 hours after the initial IN spray." | 2.76 | Sniffing out endodontic pain: use of an intranasal analgesic in a randomized clinical trial. ( Bowles, WR; Eggleston, GW; Johnson, N; Lunos, S; Turner, CL; Wiedmann, TS, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 4 (30.77) | 2.80 |
| Authors | Studies |
|---|---|
| Elnaghy, AM | 3 |
| Elshazli, AH | 3 |
| Elsaka, SE | 3 |
| Hegde, V | 1 |
| Shanmugasundaram, S | 1 |
| Shaikh, S | 1 |
| Kulkarni, V | 1 |
| Suresh, N | 1 |
| Setzer, FC | 1 |
| Nagendrababu, V | 1 |
| Nivedha, V | 1 |
| Sherwood, IA | 1 |
| Abbott, PV | 2 |
| Ramaprabha, B | 1 |
| Bhargavi, PV | 1 |
| Faghihian, H | 1 |
| Faghihian, R | 1 |
| Khademi, A | 1 |
| Aggarwal, V | 2 |
| Stentz, D | 1 |
| Drum, M | 2 |
| Reader, A | 2 |
| Nusstein, J | 2 |
| Fowler, S | 2 |
| Beck, M | 2 |
| Watts, K | 1 |
| Balzer, S | 1 |
| Akhlaghi, N | 1 |
| Azarshab, M | 1 |
| Akhoundi, N | 1 |
| Meraji, N | 1 |
| Yadav, M | 1 |
| Grewal, MS | 1 |
| Grewal, S | 1 |
| Deshwal, P | 1 |
| Akhlaghi, NM | 1 |
| Hormozi, B | 1 |
| Khalilak, Z | 1 |
| Singla, M | 1 |
| Kabi, D | 1 |
| Turner, CL | 1 |
| Eggleston, GW | 1 |
| Lunos, S | 1 |
| Johnson, N | 1 |
| Wiedmann, TS | 1 |
| Bowles, WR | 1 |
| Mellor, AC | 1 |
| Dorman, ML | 1 |
| Girdler, NM | 1 |
| Penniston, SG | 1 |
| Hargreaves, KM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Preoperative Oral Tramadol on the Anaesthetic Efficacy of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind, Controlled Study[NCT04961268] | 250 participants (Actual) | Interventional | 2020-06-01 | Completed | |||
| Effectiveness of Oral Premedication on the Success Rate of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: A Prospective, Double-blind, Randomized Controlled Trial[NCT05097768] | 250 participants (Actual) | Interventional | 2021-08-15 | Completed | |||
| Comparative Evaluation of Preoperative Methylprednisolone or Ibuprofen on Anesthetic Efficacy of Inferior Alveolar Nerve Blocks in Patients With Symptomatic Irreversible Pulpitis[NCT04157036] | Phase 3 | 3 participants (Actual) | Interventional | 2020-02-01 | Terminated (stopped due to COVID halted recruitment for 2 years. A majority of patients eligible for the study had already taken preoperative analgesics, which disqualified them for the study.) | ||
| Effect of Ketorolac Premedication on Anesthetic Efficiency of Inferior Alveolar Nerve Block, Pre-Treatment and Post-Endodontic Pain in Teeth With Irreversible Pulpitis: A Randomized Controlled Double Blinded Trial[NCT02940405] | 38 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | |||
| Comparison of the Efficacy of Prophylactic Intraligamentary Injection of Piroxicam Versus Mepecaine for Management of Post-endodontic Pain in Posterior Teeth[NCT03006107] | 26 participants (Anticipated) | Interventional | 2016-12-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 trials available for ketorolac and Inflammation, Endodontic
1 other study available for ketorolac and Inflammation, Endodontic
| Article | Year |
|---|---|
Pre-operative ketorolac efficacy with different anesthetics, irrigants during single visit root canal treatment of mandibular molars with acute irreversible pulpitis.
Topics: Anesthesia, Dental; Anesthetics, Local; Carticaine; Dental Pulp Cavity; Double-Blind Method; Humans; | 2020 |