Page last updated: 2024-10-29

ketorolac and Infertility

ketorolac has been researched along with Infertility in 1 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Infertility: A reduced or absent capacity to reproduce.

Research Excerpts

ExcerptRelevanceReference
"To study the effect of ketorolac, a potent anti-inflammatory medication, on in vitro fertilization (IVF) pregnancy outcomes when used at the time of oocyte retrieval."7.79The effect of ketorolac on pregnancy rates when used immediately after oocyte retrieval. ( Hurst, BS; Kacemi-Bourhim, L; Marshburn, PB; Matthews, M; Mesen, TB; Norton, HJ; Usadi, RS, 2013)
"To study the effect of ketorolac, a potent anti-inflammatory medication, on in vitro fertilization (IVF) pregnancy outcomes when used at the time of oocyte retrieval."3.79The effect of ketorolac on pregnancy rates when used immediately after oocyte retrieval. ( Hurst, BS; Kacemi-Bourhim, L; Marshburn, PB; Matthews, M; Mesen, TB; Norton, HJ; Usadi, RS, 2013)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mesen, TB1
Kacemi-Bourhim, L1
Marshburn, PB1
Usadi, RS1
Matthews, M1
Norton, HJ1
Hurst, BS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Blinded Placebo Controlled Trial Assessing Ketorolac (Toradol) at Oocyte Retrieval[NCT06026553]Phase 1400 participants (Anticipated)Interventional2022-08-10Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

1 other study available for ketorolac and Infertility

ArticleYear
The effect of ketorolac on pregnancy rates when used immediately after oocyte retrieval.
    Fertility and sterility, 2013, Volume: 100, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedule; Embryo Implantation; F

2013