Page last updated: 2024-10-29

ketorolac and Hypertension

ketorolac has been researched along with Hypertension in 6 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"This case report describes postoperative, reversible renal dysfunction and hypertension in a 5-year-old healthy boy after administration of relevant doses of ketorolac during anaesthesia."3.75[Ketorolac as a possible cause of reversible renal dysfunction in a 5-year-old child]. ( Knudsen, SM; Mantoni, T; Walther-Larsen, S, 2009)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asirvatham-Jeyaraj, N1
Jones, AD1
Burnett, R1
Fink, GD1
Bordlee, JW1
Beakley, BD1
Mody, R1
McConville, AP1
Weed, JT1
McClure, BP1
Foldes, PJ1
Ma, JG1
Kaye, AD1
Eskander, JP1
Sitkin, SI1
Davydova, OB1
Kostin, IO1
Gasparian, AL1
Knudsen, SM1
Mantoni, T1
Walther-Larsen, S1
Rossi, P1
Nappi, G1
Carvajal, K1
El Hafidi, M1
BaƱos, G1

Trials

1 trial available for ketorolac and Hypertension

ArticleYear
[Use of analgesia and sedation in dental implantology in patients with concomitant hypertension].
    Stomatologiia, 2015, Volume: 94, Issue:1

    Topics: Anesthesia, Dental; Anesthesia, Local; Blood Pressure; Conscious Sedation; Dental Implantation; Fema

2015

Other Studies

5 other studies available for ketorolac and Hypertension

ArticleYear
Brain Prostaglandin D2 Increases Neurogenic Pressor Activity and Mean Arterial Pressure in Angiotensin II-Salt Hypertensive Rats.
    Hypertension (Dallas, Tex. : 1979), 2019, Volume: 74, Issue:6

    Topics: Angiotensin II; Animals; Arterial Pressure; Biomarkers; Brain; Chromatography, Liquid; Cyclooxygenas

2019
A case of paradoxical presentation of a postural postdural puncture headache after combined spinal-epidural anesthesia.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia,

2017
[Ketorolac as a possible cause of reversible renal dysfunction in a 5-year-old child].
    Ugeskrift for laeger, 2009, Apr-20, Volume: 171, Issue:17

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Hernia, Umbilical; Humans; Hypertension;

2009
Bath-related headache: the first European case.
    Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:12

    Topics: Adrenergic beta-Antagonists; Analgesics; Baths; Female; Headache; Humans; Hypertension; Ketorolac; M

2006
Myocardial damage due to ischemia and reperfusion in hypertriglyceridemic and hypertensive rats: participation of free radicals and calcium overload.
    Journal of hypertension, 1999, Volume: 17, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Calcium; Creatine Kinase; Cyclic N-Oxides; Free Radicals; Heart Rate;

1999