ketorolac has been researched along with Hyperkalemia in 3 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report and describe the apparent first case of hyperkalemia following intramuscular administration of ketorolac and to discuss the proposed mechanism of action." | 7.68 | Hyperkalemia associated with ketorolac. ( Giannini, VS; Rotenberg, FA, 1992) |
| "To report and describe the apparent first case of hyperkalemia following intramuscular administration of ketorolac and to discuss the proposed mechanism of action." | 3.68 | Hyperkalemia associated with ketorolac. ( Giannini, VS; Rotenberg, FA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kelley, M | 1 |
| Bastani, B | 1 |
| Jaquenod, M | 1 |
| Rönnhedh, C | 1 |
| Cousins, MJ | 1 |
| Eckstein, RP | 1 |
| Jordan, V | 1 |
| Mather, LE | 1 |
| Power, I | 1 |
| Rotenberg, FA | 1 |
| Giannini, VS | 1 |
3 other studies available for ketorolac and Hyperkalemia
| Article | Year |
|---|---|
Ketorolac-induced acute renal failure and hyperkalemia.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hyperkalemia; Ketorolac; Male; | 1995 |
Factors influencing ketorolac-associated perioperative renal dysfunction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Glomerular Filtration Rate; Hyperkalemia; Ketorola | 1998 |
Hyperkalemia associated with ketorolac.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hyperkalemia; Injections, Intramuscular | 1992 |