Page last updated: 2024-10-29

ketorolac and Hyperemia

ketorolac has been researched along with Hyperemia in 8 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crecelius, AR1
Luckasen, GJ1
Larson, DG1
Dinenno, FA2
Casey, DP2
Joyner, MJ5
Parker, BA1
Tschakovsky, ME1
Augeri, AL1
Polk, DM1
Thompson, PD1
Kiernan, FJ1
Lopez, MG1
Silva, BM1
Schrage, WG3
Dietz, NM1
Eisenach, JH1
Lorenzo, S1
Minson, CT1

Trials

2 trials available for ketorolac and Hyperemia

ArticleYear
Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails.
    European journal of applied physiology, 2013, Volume: 113, Issue:6

    Topics: Blood Pressure; Enzyme Inhibitors; Exercise; Female; Forearm; Hand Strength; Humans; Hyperemia; Isch

2013
Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans.
    The Journal of physiology, 2007, Feb-15, Volume: 579, Issue:Pt 1

    Topics: Aged; Aged, 80 and over; Aging; Blood Pressure; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female

2007

Other Studies

6 other studies available for ketorolac and Hyperemia

ArticleYear
KIR channel activation contributes to onset and steady-state exercise hyperemia in humans.
    American journal of physiology. Heart and circulatory physiology, 2014, Sep-01, Volume: 307, Issue:5

    Topics: Adult; Barium Compounds; Chlorides; Cyclooxygenase Inhibitors; Exercise; Female; Forearm; Humans; Hy

2014
Prostaglandins do not contribute to the nitric oxide-mediated compensatory vasodilation in hypoperfused exercising muscle.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:1

    Topics: Acetylcholine; Blood Pressure; Brachial Artery; Catheterization; Cyclooxygenase Inhibitors; Enzyme I

2011
Heterogenous vasodilator pathways underlie flow-mediated dilation in men and women.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:3

    Topics: Adult; Analysis of Variance; Blood Flow Velocity; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fema

2011
Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans.
    The Journal of physiology, 2004, Jun-01, Volume: 557, Issue:Pt 2

    Topics: Adult; Brachial Artery; Cyclooxygenase Inhibitors; Drug Combinations; Enzyme Inhibitors; Exercise; F

2004
Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:5

    Topics: Adenosine Triphosphate; Adult; Enzyme Inhibitors; Exercise; Female; Forearm; Glyburide; Humans; Hype

2006
Human cutaneous reactive hyperaemia: role of BKCa channels and sensory nerves.
    The Journal of physiology, 2007, Nov-15, Volume: 585, Issue:Pt 1

    Topics: Adult; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Hyperemia; Ketorolac; Large-Con

2007