ketorolac has been researched along with Hemorrhage in 19 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Hemorrhage: Bleeding or escape of blood from a vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We sought to determine if the use of intraoperative ketorolac as part of a multimodal ERAS protocol increased the risk of bleeding complications in breast surgery." | 9.30 | Intraoperative Ketorolac Use Does Not Increase the Risk of Bleeding in Breast Surgery. ( Andaz, C; Borgen, P; Flom, P; Fortes, TA; Manasseh, DM; Rojas, KE, 2019) |
| "Perioperative ketorolac alone is not associated with an increased risk of significant bleeding in children undergoing appendectomy for perforated appendicitis." | 8.12 | Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis. ( Kelley-Quon, LI; Kim, E; Kingston, P; Lascano, D; Ourshalimian, S; Russell, CJ, 2022) |
| "Ketorolac is useful in acute pain management to avoid opiate-related complications; however, some surgeons fear associated acute kidney injury (AKI) and bleeding despite a paucity of literature on ketorolac use in trauma patients." | 8.02 | Ketorolac Use for Pain Management in Trauma Patients With Rib Fractures Does not Increase of Acute Kidney Injury or Incidence of Bleeding. ( Chao, E; DeHaan, S; Jureller, M; Kaban, JM; Laikhram, D; Lewis, E; Reddy, SH; Simon, R; Stone, ME; Torabi, J, 2021) |
| "Determine the impact of ketorolac on post-tonsillectomy hemorrhage (PTH) and narcotic administration in children undergoing tonsillectomy." | 7.96 | Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia. ( Dahl, JP; Gettelfinger, JD; Matt, BH; Pflum, ZE; Rabbani, CC; Sadhasivam, S; Ye, MJ, 2020) |
| "0001) and required twice the rescue dosage (p = 0." | 6.68 | Effect of ketorolac on bleeding time and postoperative pain in children: a double-blind, placebo-controlled comparison with meperidine. ( Bean-Lijewski, JD; Hunt, RD, 1996) |
| " We sought to determine if the use of intraoperative ketorolac as part of a multimodal ERAS protocol increased the risk of bleeding complications in breast surgery." | 5.30 | Intraoperative Ketorolac Use Does Not Increase the Risk of Bleeding in Breast Surgery. ( Andaz, C; Borgen, P; Flom, P; Fortes, TA; Manasseh, DM; Rojas, KE, 2019) |
| "Acetaminophen plus codeine is effective in pain control in polytrauma patients at least in our series." | 5.14 | Acetaminophen plus codeine compared to ketorolac in polytrauma patients. ( Buccelletti, F; Calcinaro, S; Carroccia, A; De Marco, G; Franceschi, F; Gentiloni Silveri, N; Giannuzzi, R; Gilardi, E; Giupponi, B; Mancini, F; Marini, M; Marsiliani, D; Merra, G; Potenza, A, 2010) |
| "Ketorolac can be used to treat pain after congenital heart surgery without an increased risk of bleeding complications." | 5.11 | Prospective randomized trial of ketorolac after congenital heart surgery. ( Daggett, C; Drant, S; Gupta, A; Lewis, A; Rivero, N, 2004) |
| "The use of ketorolac in children undergoing tonsillectomy remains limited because of the concern about postoperative bleeding." | 4.93 | Pediatric Tonsillectomy and Ketorolac. ( Austin, PN; Phillips-Reed, LD; Rodriguez, RE, 2016) |
| "Perioperative ketorolac alone is not associated with an increased risk of significant bleeding in children undergoing appendectomy for perforated appendicitis." | 4.12 | Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis. ( Kelley-Quon, LI; Kim, E; Kingston, P; Lascano, D; Ourshalimian, S; Russell, CJ, 2022) |
| "Ketorolac is useful in acute pain management to avoid opiate-related complications; however, some surgeons fear associated acute kidney injury (AKI) and bleeding despite a paucity of literature on ketorolac use in trauma patients." | 4.02 | Ketorolac Use for Pain Management in Trauma Patients With Rib Fractures Does not Increase of Acute Kidney Injury or Incidence of Bleeding. ( Chao, E; DeHaan, S; Jureller, M; Kaban, JM; Laikhram, D; Lewis, E; Reddy, SH; Simon, R; Stone, ME; Torabi, J, 2021) |
| "Determine the impact of ketorolac on post-tonsillectomy hemorrhage (PTH) and narcotic administration in children undergoing tonsillectomy." | 3.96 | Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia. ( Dahl, JP; Gettelfinger, JD; Matt, BH; Pflum, ZE; Rabbani, CC; Sadhasivam, S; Ye, MJ, 2020) |
| "Caffeine or ketorolac decrease the risk of retinopathy of prematurity and may act synergistically to improve beneficial effect." | 3.83 | Pharmacologic synergism of ocular ketorolac and systemic caffeine citrate in rat oxygen-induced retinopathy. ( Ahmad, T; Aranda, JV; Beharry, KD; Bronshtein, V; Cai, CL; Lazzaro, DR; Sadeh, J; Valencia, GB, 2016) |
| "0001) and required twice the rescue dosage (p = 0." | 2.68 | Effect of ketorolac on bleeding time and postoperative pain in children: a double-blind, placebo-controlled comparison with meperidine. ( Bean-Lijewski, JD; Hunt, RD, 1996) |
| "Ketorolac use has significantly expanded for postoperative pain management since it first became available in the United States, primarily due to well established effects on patient pain scores and its ability to reduce perioperative opioid requirements." | 2.55 | Safety Considerations in the Use of Ketorolac for Postoperative Pain. ( Kodumudi, G; Lipana, L; Maslin, B; Roth, B; Vadivelu, N, 2017) |
| "Ketorolac was associated with significantly longer closure times vs untreated control at both the 2." | 1.56 | Platelet Function: Meloxicam Intravenous in Whole Blood Samples From Healthy Volunteers. ( Du, W; Freyer, A; Hobson, S; Jahr, JS; Mack, R; McCallum, S; Minger, K; Searle, S, 2020) |
| "Ellagic acid is a major compound found in certain fruits and nuts." | 1.36 | The effect of ellagic acid on platelet activation as measured by the quantification of P-selectin using flow cytometry. ( Attilio, P; Kane, N; Merritt, C; O'Sullivan, J; Sims, J, 2010) |
| "Ketorolac is an injectable nonsteroidal anti-inflammatory drug that is often used as a transitional short-term analgesic to treat moderate pain and to decrease opioid use." | 1.33 | Safety of ketorolac in neonates and infants after cardiac surgery. ( Carberry, KE; Moffett, BS; Mott, AR; Wann, TI, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 6 (31.58) | 2.80 |
| Authors | Studies |
|---|---|
| Kingston, P | 1 |
| Lascano, D | 1 |
| Ourshalimian, S | 1 |
| Russell, CJ | 1 |
| Kim, E | 1 |
| Kelley-Quon, LI | 1 |
| Jahr, JS | 1 |
| Searle, S | 1 |
| McCallum, S | 1 |
| Mack, R | 1 |
| Minger, K | 1 |
| Freyer, A | 1 |
| Du, W | 1 |
| Hobson, S | 1 |
| Rabbani, CC | 2 |
| Pflum, ZE | 2 |
| Ye, MJ | 2 |
| Gettelfinger, JD | 2 |
| Sadhasivam, S | 2 |
| Matt, BH | 2 |
| Dahl, JP | 2 |
| Torabi, J | 1 |
| Kaban, JM | 1 |
| Lewis, E | 1 |
| Laikhram, D | 1 |
| Simon, R | 1 |
| DeHaan, S | 1 |
| Jureller, M | 1 |
| Chao, E | 1 |
| Reddy, SH | 1 |
| Stone, ME | 1 |
| Pinchman, E | 1 |
| Metcalfe, B | 1 |
| Higgins, M | 1 |
| Mouzakes, J | 1 |
| Ehlers, M | 1 |
| Rojas, KE | 1 |
| Fortes, TA | 1 |
| Flom, P | 1 |
| Manasseh, DM | 1 |
| Andaz, C | 1 |
| Borgen, P | 1 |
| Aranda, JV | 2 |
| Cai, CL | 1 |
| Ahmad, T | 1 |
| Bronshtein, V | 1 |
| Sadeh, J | 1 |
| Valencia, GB | 2 |
| Lazzaro, DR | 1 |
| Beharry, KD | 2 |
| Maslin, B | 1 |
| Lipana, L | 1 |
| Roth, B | 1 |
| Kodumudi, G | 1 |
| Vadivelu, N | 1 |
| Phillips-Reed, LD | 1 |
| Austin, PN | 1 |
| Rodriguez, RE | 1 |
| Franceschi, F | 1 |
| Buccelletti, F | 1 |
| Marsiliani, D | 1 |
| Carroccia, A | 1 |
| Giupponi, B | 1 |
| De Marco, G | 1 |
| Gilardi, E | 1 |
| Merra, G | 1 |
| Mancini, F | 1 |
| Potenza, A | 1 |
| Giannuzzi, R | 1 |
| Calcinaro, S | 1 |
| Marini, M | 1 |
| Gentiloni Silveri, N | 1 |
| Attilio, P | 1 |
| Merritt, C | 1 |
| Sims, J | 1 |
| Kane, N | 1 |
| O'Sullivan, J | 1 |
| Gupta, A | 1 |
| Daggett, C | 1 |
| Drant, S | 1 |
| Rivero, N | 1 |
| Lewis, A | 1 |
| Moffett, BS | 1 |
| Wann, TI | 1 |
| Carberry, KE | 1 |
| Mott, AR | 1 |
| O'Leary, M | 1 |
| Martin, P | 1 |
| McLean, AS | 1 |
| Robb, PJ | 1 |
| Rollin, AM | 1 |
| Saunders, DA | 1 |
| Bean-Lijewski, JD | 1 |
| Hunt, RD | 1 |
| O'Hanlon, JJ | 1 |
| Beers, H | 1 |
| Huss, BK | 1 |
| Milligan, KR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Perioperative Usage of Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectom[NCT05074056] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| A Randomized Blinded Placebo Controlled Trial Assessing Ketorolac (Toradol) at Oocyte Retrieval[NCT06026553] | Phase 1 | 400 participants (Anticipated) | Interventional | 2022-08-10 | Recruiting | ||
| Prospective, Randomized, Allocation-Concealed, Blinded Study Designed to Compare Ketorolac Sublingual and Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children[NCT02653742] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| A Randomized, Double-blinded, Placebo-controlled Study of Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy[NCT03453541] | Phase 4 | 600 participants (Anticipated) | Interventional | 2017-11-21 | Recruiting | ||
| Continuous Infusion Versus Intermittent Ketorolac for Postoperative Pain Control in Pediatric Cardiac Surgery Patients[NCT04040452] | Phase 4 | 166 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ketorolac and Hemorrhage
| Article | Year |
|---|---|
Safety Considerations in the Use of Ketorolac for Postoperative Pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Hemorrhage; Humans; Ketorolac; Pain, Postoperative | 2017 |
Safety Considerations in the Use of Ketorolac for Postoperative Pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Hemorrhage; Humans; Ketorolac; Pain, Postoperative | 2017 |
Safety Considerations in the Use of Ketorolac for Postoperative Pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Hemorrhage; Humans; Ketorolac; Pain, Postoperative | 2017 |
Safety Considerations in the Use of Ketorolac for Postoperative Pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Hemorrhage; Humans; Ketorolac; Pain, Postoperative | 2017 |
Pediatric Tonsillectomy and Ketorolac.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Hemorrhage; Humans; In | 2016 |
Nonsteroidal anti-inflammatory drugs (NSAIDs) in the newborn - which ones?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Hemorrhage; Humans; Ibuprofen; I | 2009 |
5 trials available for ketorolac and Hemorrhage
| Article | Year |
|---|---|
Intraoperative Ketorolac Use Does Not Increase the Risk of Bleeding in Breast Surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasm | 2019 |
Acetaminophen plus codeine compared to ketorolac in polytrauma patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, | 2010 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Prospective randomized trial of ketorolac after congenital heart surgery.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cardiopulmonary Bypass; Chi | 2004 |
Effect of ketorolac on bleeding time and postoperative pain in children: a double-blind, placebo-controlled comparison with meperidine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Bleeding Time; Child; Child, Preschool; Double-Blind M | 1996 |
A comparison of the effect of intramuscular diclofenac, ketorolac or piroxicam on post-operative pain following laparoscopy.
Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bronchial Disea | 1996 |
11 other studies available for ketorolac and Hemorrhage
| Article | Year |
|---|---|
Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis.
Topics: Appendectomy; Appendicitis; Child; Hemorrhage; Humans; Ibuprofen; Ketorolac; Retrospective Studies | 2022 |
Platelet Function: Meloxicam Intravenous in Whole Blood Samples From Healthy Volunteers.
Topics: Adenosine Diphosphate; Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia.
Topics: Adenoidectomy; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; | 2020 |
Ketorolac Use for Pain Management in Trauma Patients With Rib Fractures Does not Increase of Acute Kidney Injury or Incidence of Bleeding.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Stero | 2021 |
Letter to the editor: In support of "Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia".
Topics: Adenoidectomy; Analgesia; Child; Hemorrhage; Humans; Ketorolac; Tonsillectomy | 2021 |
This is in response to the Letter to the Editor for our publication "Intraoperative ketorolac for pediatric tonsillectomy: Effect on post-tonsillectomy hemorrhage and perioperative analgesia" submitted by Pinchman et al. (IJPORL-D-20-01791).
Topics: Adenoidectomy; Analgesia; Child; Hemorrhage; Humans; Ketorolac; Tonsillectomy | 2021 |
Pharmacologic synergism of ocular ketorolac and systemic caffeine citrate in rat oxygen-induced retinopathy.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Apyrase; Arteries; Body Weight; | 2016 |
The effect of ellagic acid on platelet activation as measured by the quantification of P-selectin using flow cytometry.
Topics: Anesthesia; Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dietary Supplements; Drug Evaluati | 2010 |
Safety of ketorolac in neonates and infants after cardiac surgery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Urea Nitrogen; Cardiac Surgical Procedures; Cohort St | 2006 |
Oliguria and haemorrhage after intramuscular injection of ketorolac trometamol.
Topics: Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Hemorrhage; Humans; Injections, Intramusc | 1993 |
Diclofenac and post-tonsillectomy haemorrhage.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Hemorrhage; Humans; K | 1995 |