ketorolac has been researched along with Hematoma in 14 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Hematoma: A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After accounting for associations with longer operative times, concomitant IBBR, and bilateral procedures, ketorolac administration did not remain an independent risk factor for hematoma formation." | 8.12 | Postoperative Hematomas in the Era of Outpatient Mastectomy: Is Ketorolac Really to Blame? ( Abujbarah, SM; Ahmad, S; Casey, W; Craner, R; Cronin, PA; Jogerst, K; Kosiorek, HE; Pockaj, BA; Rebecca, A, 2022) |
| " Ketorolac has well-documented opioid-sparing effects in the postoperative period; however, its use is limited because of concerns of postoperative bleeding and hematoma formation." | 7.88 | Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases. ( Firriolo, JM; Labow, BI; Nuzzi, LC; Schmidtberg, LC, 2018) |
| "Incidence of postoperative hematoma and perioperative ketorolac administration." | 7.77 | Ketorolac in thyroid surgery: quantifying the risk of hematoma. ( Chin, CJ; Franklin, JH; Fung, K; Sowerby, L; Turner, B; Yoo, JH, 2011) |
| "Antithrombotic agent usage, postoperative pain, and two or more doses of ketorolac postoperatively were identified as independent risk factors for PH." | 5.51 | Perioperative risk factors for post-thyroidectomy hematoma: Significance of pain and ketorolac usage. ( Ahn, SH; Jeong, WJ; Jung, YH; Kim, Y; Lee, M; Rhee, J, 2019) |
| "Ketorolac has a strong antiplatelet activity and further acts by the inhibition of platelet function, which may last as long as 24 h after the last administration." | 5.32 | Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. ( Halkic, N; Vuilleumier, H, 2003) |
| "After accounting for associations with longer operative times, concomitant IBBR, and bilateral procedures, ketorolac administration did not remain an independent risk factor for hematoma formation." | 4.12 | Postoperative Hematomas in the Era of Outpatient Mastectomy: Is Ketorolac Really to Blame? ( Abujbarah, SM; Ahmad, S; Casey, W; Craner, R; Cronin, PA; Jogerst, K; Kosiorek, HE; Pockaj, BA; Rebecca, A, 2022) |
| " Ketorolac has well-documented opioid-sparing effects in the postoperative period; however, its use is limited because of concerns of postoperative bleeding and hematoma formation." | 3.88 | Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases. ( Firriolo, JM; Labow, BI; Nuzzi, LC; Schmidtberg, LC, 2018) |
| "We conducted a retrospective review following concerns involving a suspected increase in the requirement for surgical re-exploration for hematoma evacuation when ketorolac was administered perioperatively in patients undergoing reduction mammoplasty." | 3.78 | Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty. ( Cawthorn, TR; Davidson, JS; Phelan, R; Turner, KE, 2012) |
| "Antithrombotic agent usage, postoperative pain, and two or more doses of ketorolac postoperatively were identified as independent risk factors for PH." | 1.51 | Perioperative risk factors for post-thyroidectomy hematoma: Significance of pain and ketorolac usage. ( Ahn, SH; Jeong, WJ; Jung, YH; Kim, Y; Lee, M; Rhee, J, 2019) |
| "Ketorolac was associated with fewer readmissions (OR, 0." | 1.48 | Postoperative Ketorolac in Breast and Body Contouring Procedures: A Nationwide Claims Analysis. ( Bennett, KG; Chung, KC; Chung, TT; Kelley, BP; Sacks, G; Sears, ED; Waljee, JF, 2018) |
| "Ketorolac has a strong antiplatelet activity and further acts by the inhibition of platelet function, which may last as long as 24 h after the last administration." | 1.32 | Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. ( Halkic, N; Vuilleumier, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Abujbarah, SM | 1 |
| Jogerst, K | 1 |
| Kosiorek, HE | 1 |
| Ahmad, S | 1 |
| Cronin, PA | 1 |
| Casey, W | 1 |
| Craner, R | 1 |
| Rebecca, A | 1 |
| Pockaj, BA | 1 |
| Mikhaylov, Y | 1 |
| Weinstein, B | 1 |
| Schrank, TP | 1 |
| Swartz, JD | 1 |
| Ulm, JP | 1 |
| Armstrong, MB | 1 |
| Delaney, KO | 1 |
| Firriolo, JM | 1 |
| Nuzzi, LC | 1 |
| Schmidtberg, LC | 1 |
| Labow, BI | 1 |
| Kelley, BP | 1 |
| Chung, KC | 1 |
| Chung, TT | 1 |
| Bennett, KG | 1 |
| Sacks, G | 1 |
| Sears, ED | 1 |
| Waljee, JF | 1 |
| Lee, M | 1 |
| Rhee, J | 1 |
| Kim, Y | 1 |
| Jung, YH | 1 |
| Ahn, SH | 1 |
| Jeong, WJ | 1 |
| Brown, V | 1 |
| Martin, J | 1 |
| Magee, D | 1 |
| Chin, CJ | 1 |
| Franklin, JH | 1 |
| Turner, B | 1 |
| Sowerby, L | 1 |
| Fung, K | 1 |
| Yoo, JH | 1 |
| Cawthorn, TR | 1 |
| Phelan, R | 1 |
| Davidson, JS | 1 |
| Turner, KE | 1 |
| Vuilleumier, H | 1 |
| Halkic, N | 1 |
| Ignjatovic, D | 1 |
| Alcaraz, A | 1 |
| López-Herce, J | 1 |
| Seriñá, C | 1 |
| Bueso-Inchausti, A | 1 |
| Saez, MJ | 1 |
| Sancho, L | 1 |
| Gerancher, JC | 1 |
| Waterer, R | 1 |
| Middleton, J | 1 |
| Sharma, S | 1 |
| Chang, DW | 1 |
| Koutz, C | 1 |
| Evans, GR | 1 |
| Robb, GL | 1 |
| Langstein, HN | 1 |
| Kroll, SS | 1 |
| Garcha, IS | 1 |
| Bostwick, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Perioperative Systemic Acetaminophen to Improve Postoperative Quality of Recovery After Ambulatory Breast Surgery[NCT01852955] | 70 participants (Actual) | Interventional | 2013-11-30 | Completed | |||
| Does Ketorolac Increase the Risk of Hematoma After Reduction Mammoplasty? A Case-control Study.[NCT03280043] | 80 participants (Actual) | Observational | 2015-09-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Postoperative opioid consumption over 24 hours. Converted into oral mg of morpine equivalents. (NCT01852955)
Timeframe: 24 hour
| Intervention | oral mg of morpine equivalents (Median) |
|---|---|
| IV Acetaminophen | 20 |
| Placebo | 30 |
Postoperative pain within the post anesthesia care unit after surgery. Area under the numeric rating scale for pain versus time curve in the post anesthesia care unit (score * min).Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve in the post anesthesia care unit ( score * min). Area under a curve units of the horizontal axis multiplied by the units of the vertical axis. A higher value indicates more pain and time in the Post Anesthesia Care Unit.The range is 0 pain to x time in minutes x 1 hour to 5 hour ( 60-300 minutes) . The pain scores were collected at 15 minute intervals from the time of admission to the PACU. The area under the NRS pain scale versus time curve was calculated using the trapezoidal method as an indicator of pain burden during early recovery (Graph Pad Prism ver 5.03, Graph Pad Software INC. (NCT01852955)
Timeframe: Time in the post anesthesia care unit after surgery (average of 5 hours)
| Intervention | (units on a scale * minutes (Median) |
|---|---|
| IV Acetaminophen | 255 |
| Placebo | 240 |
Quality of recovery score 24 hours after the surgical procedure. Total score range of 40 (poor recovery) and a score of 200 (good recovery). (NCT01852955)
Timeframe: 24 hours after the surgical procedure
| Intervention | units on a scale (Median) |
|---|---|
| IV Acetaminophen | 189 |
| Placebo | 183 |
1 review available for ketorolac and Hematoma
| Article | Year |
|---|---|
Transient paraparesis after postdural puncture spinal hematoma in a patient receiving ketorolac.
Topics: Aged; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Ketorol | 1997 |
13 other studies available for ketorolac and Hematoma
| Article | Year |
|---|---|
Postoperative Hematomas in the Era of Outpatient Mastectomy: Is Ketorolac Really to Blame?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Female; Hematoma; Humans; Ketorolac; Mast | 2022 |
Ketorolac and Hematoma Incidence in Postmastectomy Implant-Based Breast Reconstruction.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Implants; Breast Neoplasms; Female; Hematoma; Humans | 2018 |
Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedul | 2018 |
Postoperative Ketorolac in Breast and Body Contouring Procedures: A Nationwide Claims Analysis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Contouring; Breast; Female; Hematoma; Hum | 2018 |
Perioperative risk factors for post-thyroidectomy hematoma: Significance of pain and ketorolac usage.
Topics: Adult; Case-Control Studies; Female; Follow-Up Studies; Hematoma; Humans; Incidence; Ketorolac; Male | 2019 |
A rare case of subcapsular liver haematoma following laparoscopic cholecystectomy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Cholecystectomy, Laparoscopic; Cholelithias | 2015 |
Ketorolac in thyroid surgery: quantifying the risk of hematoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Ketorolac; Male; Middle Aged; Thy | 2011 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K | 2012 |
Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Coagulation; Chemical and Drug Induced Liver I | 2003 |
Comment to: Vuilleumier H, Halkic N. Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. Surg Endosc 2006, online first.
Topics: Blood Coagulation; Cholecystectomy, Laparoscopic; Follow-Up Studies; Gastrointestinal Hemorrhage; He | 2007 |
Gastrointestinal bleeding following ketorolac administration in a pediatric patient.
Topics: Analgesics, Non-Narcotic; Aneurysm, False; Aortic Coarctation; Female; Gastrointestinal Hemorrhage; | 1996 |
Incidence of hematoma associated with ketorolac after TRAM flap breast reconstruction.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 2001 |
Postoperative hematomas associated with Toradol.
Topics: Analgesics; Hematoma; Humans; Ketorolac; Postoperative Complications; Tolmetin | 1991 |