Page last updated: 2024-10-29

ketorolac and Hematoma

ketorolac has been researched along with Hematoma in 14 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Hematoma: A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.

Research Excerpts

ExcerptRelevanceReference
"After accounting for associations with longer operative times, concomitant IBBR, and bilateral procedures, ketorolac administration did not remain an independent risk factor for hematoma formation."8.12Postoperative Hematomas in the Era of Outpatient Mastectomy: Is Ketorolac Really to Blame? ( Abujbarah, SM; Ahmad, S; Casey, W; Craner, R; Cronin, PA; Jogerst, K; Kosiorek, HE; Pockaj, BA; Rebecca, A, 2022)
" Ketorolac has well-documented opioid-sparing effects in the postoperative period; however, its use is limited because of concerns of postoperative bleeding and hematoma formation."7.88Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases. ( Firriolo, JM; Labow, BI; Nuzzi, LC; Schmidtberg, LC, 2018)
"Incidence of postoperative hematoma and perioperative ketorolac administration."7.77Ketorolac in thyroid surgery: quantifying the risk of hematoma. ( Chin, CJ; Franklin, JH; Fung, K; Sowerby, L; Turner, B; Yoo, JH, 2011)
"Antithrombotic agent usage, postoperative pain, and two or more doses of ketorolac postoperatively were identified as independent risk factors for PH."5.51Perioperative risk factors for post-thyroidectomy hematoma: Significance of pain and ketorolac usage. ( Ahn, SH; Jeong, WJ; Jung, YH; Kim, Y; Lee, M; Rhee, J, 2019)
"Ketorolac has a strong antiplatelet activity and further acts by the inhibition of platelet function, which may last as long as 24 h after the last administration."5.32Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. ( Halkic, N; Vuilleumier, H, 2003)
"After accounting for associations with longer operative times, concomitant IBBR, and bilateral procedures, ketorolac administration did not remain an independent risk factor for hematoma formation."4.12Postoperative Hematomas in the Era of Outpatient Mastectomy: Is Ketorolac Really to Blame? ( Abujbarah, SM; Ahmad, S; Casey, W; Craner, R; Cronin, PA; Jogerst, K; Kosiorek, HE; Pockaj, BA; Rebecca, A, 2022)
" Ketorolac has well-documented opioid-sparing effects in the postoperative period; however, its use is limited because of concerns of postoperative bleeding and hematoma formation."3.88Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases. ( Firriolo, JM; Labow, BI; Nuzzi, LC; Schmidtberg, LC, 2018)
"We conducted a retrospective review following concerns involving a suspected increase in the requirement for surgical re-exploration for hematoma evacuation when ketorolac was administered perioperatively in patients undergoing reduction mammoplasty."3.78Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty. ( Cawthorn, TR; Davidson, JS; Phelan, R; Turner, KE, 2012)
"Antithrombotic agent usage, postoperative pain, and two or more doses of ketorolac postoperatively were identified as independent risk factors for PH."1.51Perioperative risk factors for post-thyroidectomy hematoma: Significance of pain and ketorolac usage. ( Ahn, SH; Jeong, WJ; Jung, YH; Kim, Y; Lee, M; Rhee, J, 2019)
"Ketorolac was associated with fewer readmissions (OR, 0."1.48Postoperative Ketorolac in Breast and Body Contouring Procedures: A Nationwide Claims Analysis. ( Bennett, KG; Chung, KC; Chung, TT; Kelley, BP; Sacks, G; Sears, ED; Waljee, JF, 2018)
"Ketorolac has a strong antiplatelet activity and further acts by the inhibition of platelet function, which may last as long as 24 h after the last administration."1.32Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. ( Halkic, N; Vuilleumier, H, 2003)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (21.43)18.2507
2000's3 (21.43)29.6817
2010's7 (50.00)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Abujbarah, SM1
Jogerst, K1
Kosiorek, HE1
Ahmad, S1
Cronin, PA1
Casey, W1
Craner, R1
Rebecca, A1
Pockaj, BA1
Mikhaylov, Y1
Weinstein, B1
Schrank, TP1
Swartz, JD1
Ulm, JP1
Armstrong, MB1
Delaney, KO1
Firriolo, JM1
Nuzzi, LC1
Schmidtberg, LC1
Labow, BI1
Kelley, BP1
Chung, KC1
Chung, TT1
Bennett, KG1
Sacks, G1
Sears, ED1
Waljee, JF1
Lee, M1
Rhee, J1
Kim, Y1
Jung, YH1
Ahn, SH1
Jeong, WJ1
Brown, V1
Martin, J1
Magee, D1
Chin, CJ1
Franklin, JH1
Turner, B1
Sowerby, L1
Fung, K1
Yoo, JH1
Cawthorn, TR1
Phelan, R1
Davidson, JS1
Turner, KE1
Vuilleumier, H1
Halkic, N1
Ignjatovic, D1
Alcaraz, A1
López-Herce, J1
Seriñá, C1
Bueso-Inchausti, A1
Saez, MJ1
Sancho, L1
Gerancher, JC1
Waterer, R1
Middleton, J1
Sharma, S1
Chang, DW1
Koutz, C1
Evans, GR1
Robb, GL1
Langstein, HN1
Kroll, SS1
Garcha, IS1
Bostwick, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Perioperative Systemic Acetaminophen to Improve Postoperative Quality of Recovery After Ambulatory Breast Surgery[NCT01852955]70 participants (Actual)Interventional2013-11-30Completed
Does Ketorolac Increase the Risk of Hematoma After Reduction Mammoplasty? A Case-control Study.[NCT03280043]80 participants (Actual)Observational2015-09-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Postoperative Opioid Consumption

Postoperative opioid consumption over 24 hours. Converted into oral mg of morpine equivalents. (NCT01852955)
Timeframe: 24 hour

Interventionoral mg of morpine equivalents (Median)
IV Acetaminophen20
Placebo30

Postoperative Pain in the Post Anesthesia Care Unit

Postoperative pain within the post anesthesia care unit after surgery. Area under the numeric rating scale for pain versus time curve in the post anesthesia care unit (score * min).Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve in the post anesthesia care unit ( score * min). Area under a curve units of the horizontal axis multiplied by the units of the vertical axis. A higher value indicates more pain and time in the Post Anesthesia Care Unit.The range is 0 pain to x time in minutes x 1 hour to 5 hour ( 60-300 minutes) . The pain scores were collected at 15 minute intervals from the time of admission to the PACU. The area under the NRS pain scale versus time curve was calculated using the trapezoidal method as an indicator of pain burden during early recovery (Graph Pad Prism ver 5.03, Graph Pad Software INC. (NCT01852955)
Timeframe: Time in the post anesthesia care unit after surgery (average of 5 hours)

Intervention(units on a scale * minutes (Median)
IV Acetaminophen255
Placebo240

Quality of Recovery at 24 Hours(QoR-40 Instrument)

Quality of recovery score 24 hours after the surgical procedure. Total score range of 40 (poor recovery) and a score of 200 (good recovery). (NCT01852955)
Timeframe: 24 hours after the surgical procedure

Interventionunits on a scale (Median)
IV Acetaminophen189
Placebo183

Reviews

1 review available for ketorolac and Hematoma

ArticleYear
Transient paraparesis after postdural puncture spinal hematoma in a patient receiving ketorolac.
    Anesthesiology, 1997, Volume: 86, Issue:2

    Topics: Aged; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Ketorol

1997

Other Studies

13 other studies available for ketorolac and Hematoma

ArticleYear
Postoperative Hematomas in the Era of Outpatient Mastectomy: Is Ketorolac Really to Blame?
    Annals of surgical oncology, 2022, Volume: 29, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Female; Hematoma; Humans; Ketorolac; Mast

2022
Ketorolac and Hematoma Incidence in Postmastectomy Implant-Based Breast Reconstruction.
    Annals of plastic surgery, 2018, Volume: 80, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Implants; Breast Neoplasms; Female; Hematoma; Humans

2018
Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases.
    Plastic and reconstructive surgery, 2018, Volume: 142, Issue:5

    Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedul

2018
Postoperative Ketorolac in Breast and Body Contouring Procedures: A Nationwide Claims Analysis.
    Plastic and reconstructive surgery, 2018, Volume: 142, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Contouring; Breast; Female; Hematoma; Hum

2018
Perioperative risk factors for post-thyroidectomy hematoma: Significance of pain and ketorolac usage.
    Head & neck, 2019, Volume: 41, Issue:10

    Topics: Adult; Case-Control Studies; Female; Follow-Up Studies; Hematoma; Humans; Incidence; Ketorolac; Male

2019
A rare case of subcapsular liver haematoma following laparoscopic cholecystectomy.
    BMJ case reports, 2015, Jun-25, Volume: 2015

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Cholecystectomy, Laparoscopic; Cholelithias

2015
Ketorolac in thyroid surgery: quantifying the risk of hematoma.
    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2011, Volume: 40, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Ketorolac; Male; Middle Aged; Thy

2011
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2012, Volume: 59, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K

2012
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2012, Volume: 59, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K

2012
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2012, Volume: 59, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K

2012
Retrospective analysis of perioperative ketorolac and postoperative bleeding in reduction mammoplasty.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2012, Volume: 59, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Hematoma; Humans; Injections, Intravenous; K

2012
Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy.
    Surgical endoscopy, 2003, Volume: 17, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Coagulation; Chemical and Drug Induced Liver I

2003
Comment to: Vuilleumier H, Halkic N. Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. Surg Endosc 2006, online first.
    Surgical endoscopy, 2007, Volume: 21, Issue:7

    Topics: Blood Coagulation; Cholecystectomy, Laparoscopic; Follow-Up Studies; Gastrointestinal Hemorrhage; He

2007
Gastrointestinal bleeding following ketorolac administration in a pediatric patient.
    Journal of pediatric gastroenterology and nutrition, 1996, Volume: 23, Issue:4

    Topics: Analgesics, Non-Narcotic; Aneurysm, False; Aortic Coarctation; Female; Gastrointestinal Hemorrhage;

1996
Incidence of hematoma associated with ketorolac after TRAM flap breast reconstruction.
    Plastic and reconstructive surgery, 2001, Volume: 107, Issue:2

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Dose-Response Relationship, Drug; Drug Therapy, Combinat

2001
Postoperative hematomas associated with Toradol.
    Plastic and reconstructive surgery, 1991, Volume: 88, Issue:5

    Topics: Analgesics; Hematoma; Humans; Ketorolac; Postoperative Complications; Tolmetin

1991