ketorolac has been researched along with Gastrointestinal Hemorrhage in 19 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Method We performed a cost-effectiveness analysis of three clinical rules of the CMA, targeting adverse drug events at three levels of severity: A) persistent opioid-induced constipation, B) ketorolac-induced gastrointestinal bleeding and C) drug-induced Torsade de Pointes." | 4.12 | Cost-effectiveness of check of medication appropriateness: methodological approach. ( Bisschops, R; D'hulster, E; Luyten, J; Peetermans, WE; Quintens, C; Verbakel, JY; Willems, R, 2022) |
| "Treatment with ketorolac is completed during hospitalization; therefore, compliance is ensured." | 2.68 | Ketorolac prophylaxis against heterotopic ossification after hip replacement. ( Pritchett, JW, 1995) |
| " In general, the adverse events associated with ketorolac are similar to other NSAIDs." | 2.39 | Side effects of NSAIDs and dosing recommendations for ketorolac. ( Camu, F; Lauwers, MH; Vanlersberghe, C, 1996) |
| "There are no rational schemes for postoperative pain relief." | 1.62 | The effect of ( Akmalova, KA; Blagovestnov, DA; Epifanova, IA; Kerimova, LN; Koroshvili, VT; Muradian, AA; Sozaeva, ZA; Sychev, DA; Zastrozhin, MS, 2021) |
| "Ketorolac was 5 times more gastrotoxic than all other NSAIDs (RR, 5." | 1.30 | Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs. ( Agostinis, L; Cattaruzzi, C; García Rodríguez, LA; Troncon, MG, 1998) |
| "Ketorolac proved safe for short-term intravenous use in children more than 1 year of age when patients with known contraindications to the use of non-steroidal antiinflammatory drugs were excluded." | 1.29 | Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. ( Berde, CB; Houck, CS; McDermott, JS; Sethna, NF; Wilder, RT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (73.68) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| D'hulster, E | 1 |
| Quintens, C | 1 |
| Bisschops, R | 1 |
| Willems, R | 1 |
| Peetermans, WE | 1 |
| Verbakel, JY | 1 |
| Luyten, J | 1 |
| Muradian, AA | 1 |
| Sychev, DA | 1 |
| Blagovestnov, DA | 1 |
| Sozaeva, ZA | 1 |
| Akmalova, KA | 1 |
| Zastrozhin, MS | 1 |
| Kerimova, LN | 1 |
| Koroshvili, VT | 1 |
| Epifanova, IA | 1 |
| Van Vertloo, LR | 1 |
| Terhaar, HM | 1 |
| Viall, AK | 1 |
| Allbaugh, RA | 1 |
| Han, JB | 1 |
| Keller, EE | 1 |
| Grothe, RM | 1 |
| Ignjatovic, D | 1 |
| Pritchett, JW | 1 |
| Wiedrick, JE | 1 |
| Friesen, EG | 1 |
| Garton, AM | 1 |
| Otten, NH | 1 |
| Marcos Sánchez, F | 1 |
| Aparicio Martínez, JC | 1 |
| Arranz Nieto, MJ | 1 |
| Pérez-Navarro, AD | 1 |
| Quigley, EM | 1 |
| Ruh, P | 1 |
| Steinberg, RB | 1 |
| Tessier, EG | 1 |
| Sacanella, E | 1 |
| Muñoz, F | 1 |
| Cardellach, F | 1 |
| Estruch, R | 1 |
| Miró, O | 1 |
| Urbano-Márquez, A | 1 |
| Houck, CS | 1 |
| Wilder, RT | 1 |
| McDermott, JS | 1 |
| Sethna, NF | 1 |
| Berde, CB | 1 |
| O'Hanlon, JJ | 1 |
| Beers, H | 1 |
| Huss, BK | 1 |
| Milligan, KR | 1 |
| Alcaraz, A | 1 |
| López-Herce, J | 1 |
| Seriñá, C | 1 |
| Bueso-Inchausti, A | 1 |
| Saez, MJ | 1 |
| Sancho, L | 1 |
| Camu, F | 1 |
| Lauwers, MH | 1 |
| Vanlersberghe, C | 1 |
| Lagerkranser, M | 1 |
| Belfrage, M | 1 |
| Flordal, PA | 1 |
| Persson, E | 1 |
| García Rodríguez, LA | 1 |
| Cattaruzzi, C | 1 |
| Troncon, MG | 1 |
| Agostinis, L | 1 |
| O'Hara, DA | 1 |
| Horswell, JL | 1 |
1 review available for ketorolac and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Side effects of NSAIDs and dosing recommendations for ketorolac.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cyclooxygenase Inhibitors; Dose-Response Rela | 1996 |
2 trials available for ketorolac and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Ketorolac prophylaxis against heterotopic ossification after hip replacement.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female | 1995 |
A comparison of the effect of intramuscular diclofenac, ketorolac or piroxicam on post-operative pain following laparoscopy.
Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bronchial Disea | 1996 |
16 other studies available for ketorolac and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Cost-effectiveness of check of medication appropriateness: methodological approach.
Topics: Analgesics, Opioid; Constipation; Cost-Benefit Analysis; Drug-Related Side Effects and Adverse React | 2022 |
The effect of
Topics: Analgesics, Opioid; Cholecystectomy, Laparoscopic; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; | 2021 |
Retrospective evaluation of the incidence of gastrointestinal bleeding in dogs receiving ophthalmic nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dog Diseases; Dogs; Flurbiprofen; Gast | 2023 |
Postoperative gastrointestinal bleeding in orthognathic surgery patients: its estimated prevalence and possible association to known risk factors.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Bone Transplantation; | 2014 |
Comment to: Vuilleumier H, Halkic N. Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. Surg Endosc 2006, online first.
Topics: Blood Coagulation; Cholecystectomy, Laparoscopic; Follow-Up Studies; Gastrointestinal Hemorrhage; He | 2007 |
Upper gastrointestinal bleeding associated with oral ketorolac therapy.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedule; | 1994 |
[Upper digestive hemorrhage after oral administration of ketorolac].
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Hu | 1994 |
Ketorolac-associated upper gastrointestinal hemorrhage.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastrointestinal Hemorrhag | 1994 |
Gastrointestinal bleeding after administration of ketorolac.
Topics: Aged; Aged, 80 and over; Analgesics; Female; Gastrointestinal Hemorrhage; Humans; Injections, Intram | 1993 |
Massive haemorrhage due to colitis secondary to nonsteroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aortic Aneurysm, Abdominal; Colitis; Gastrointestinal | 1996 |
Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Prescho | 1996 |
Gastrointestinal bleeding following ketorolac administration in a pediatric patient.
Topics: Analgesics, Non-Narcotic; Aneurysm, False; Aortic Coarctation; Female; Gastrointestinal Hemorrhage; | 1996 |
[Reduce the dosage of ketorolac! Following EEC recommendations reduces the risk of hemorrhage with a marginal reduction of the analgesic effect].
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Europea | 1996 |
Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Ca | 1998 |
Bleeding diathesis after perioperative ketorolac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Humans; Ketorolac; Postoperati | 1992 |
Bleeding diathesis after perioperative ketorolac.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Humans; Ketorolac; Male; | 1992 |