ketorolac has been researched along with Gastric Ulcer in 8 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, seven (23%) of the 31 ketorolac subjects had at least one ulcer; five (16%) had gastric ulcers, and two (6%) had duodenal ulcers (p < 0." | 5.10 | Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects. ( Dhadda, S; Harris, SI; Hubbard, RC; Kuss, ME; LeComte, D; Stoltz, RR; Talwalker, S, 2002) |
| " In a single dose study, its pharmacokinetic profile was compared with that of ketorolac." | 1.35 | Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations. ( Abignente, E; Boatto, G; Calignano, A; Curcio, A; Gavini, E; La Rana, G; Melisi, D; Nieddu, M; Rimoli, MG; Russo, R; Sasso, O, 2009) |
| "Ketorolac is a non-steroidal anti-inflammatory drug." | 1.34 | Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation. ( Chaturvedi, SC; Trivedi, P; Vyas, S, 2007) |
| "Ketorolac, is a non-steroidal anti-inflammatory drug, with strong analgesic activity." | 1.31 | Solid dispersion of hydroxypropyl beta-cyclodextrin and ketorolac: enhancement of in-vitro dissolution rates, improvement in anti-inflammatory activity and reduction in ulcerogenicity in rats. ( Meshram, RN; Nagarsenker, MS; Ramprakash, G, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Curcio, A | 1 |
| Sasso, O | 1 |
| Melisi, D | 1 |
| Nieddu, M | 1 |
| La Rana, G | 1 |
| Russo, R | 1 |
| Gavini, E | 1 |
| Boatto, G | 1 |
| Abignente, E | 1 |
| Calignano, A | 1 |
| Rimoli, MG | 1 |
| Majumder, R | 1 |
| Datta, M | 1 |
| Banerjee, A | 1 |
| Bandyopadhyay, D | 1 |
| Chattopadhyay, A | 1 |
| Vyas, S | 1 |
| Trivedi, P | 1 |
| Chaturvedi, SC | 1 |
| Lilley, LL | 1 |
| Guanci, R | 1 |
| Quigley, EM | 1 |
| Donovan, JP | 1 |
| Livingston, WC | 1 |
| Godessart, N | 1 |
| Salcedo, C | 1 |
| Fernández, AG | 1 |
| Palacios, JM | 1 |
| Nagarsenker, MS | 1 |
| Meshram, RN | 1 |
| Ramprakash, G | 1 |
| Stoltz, RR | 1 |
| Harris, SI | 1 |
| Kuss, ME | 1 |
| LeComte, D | 1 |
| Talwalker, S | 1 |
| Dhadda, S | 1 |
| Hubbard, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Comparison Between Parecoxib and Placebo Added to a Standard Perioperative Analgesic Protocol for Total Knee Arthroplasty[NCT05924412] | Phase 4 | 40 participants (Anticipated) | Interventional | 2023-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ketorolac and Gastric Ulcer
| Article | Year |
|---|---|
Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects.
Topics: Age Factors; Aged; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug | 2002 |
7 other studies available for ketorolac and Gastric Ulcer
| Article | Year |
|---|---|
Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edem | 2009 |
Melatonin protects against ketorolac induced gastric mucosal toxic injuries through molecular mechanism associated with the modulation of Arylakylamine N-Acetyltransferase (AANAT) activity.
Topics: Animals; Gastric Mucosa; Ketorolac; Melatonin; Rats; Stomach; Stomach Ulcer; Ulcer | 2023 |
Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Carrag | 2007 |
Adverse effects of NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Female; Humans; Ketorolac; Middle Aged; | 1995 |
Ketorolac-related giant gastric ulcers.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ionophores; Ketorolac; Mal | 1994 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 1999 |
Solid dispersion of hydroxypropyl beta-cyclodextrin and ketorolac: enhancement of in-vitro dissolution rates, improvement in anti-inflammatory activity and reduction in ulcerogenicity in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextr | 2000 |