ketorolac has been researched along with Fractures, Bone in 7 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Fractures, Bone: Breaks in bones.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department." | 9.09 | Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. ( Cheung, NK; Cocks, RA; Jacobs, P; Lam, PK; Ng, YC; Rainer, TH; Tam, M; Wong, R, 2000) |
| "To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department." | 5.09 | Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. ( Cheung, NK; Cocks, RA; Jacobs, P; Lam, PK; Ng, YC; Rainer, TH; Tam, M; Wong, R, 2000) |
| "Ketorolac was better tolerated than meperidine." | 2.68 | Ketorolac versus meperidine for pain relief after orthopaedic surgery. ( Brown, J; Bynum, L; Cardea, J; Chang, YL; DeAndrade, JR; Howe, D; Maneatis, T; Maslanka, M; Rasmussen, GL; Reines, HD; Shefrin, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neri, E | 1 |
| Maestro, A | 1 |
| Minen, F | 1 |
| Montico, M | 1 |
| Ronfani, L | 1 |
| Zanon, D | 1 |
| Favret, A | 1 |
| Messi, G | 1 |
| Barbi, E | 1 |
| Ortiz, MI | 1 |
| Monroy-Maya, R | 1 |
| Soto-Ríos, M | 1 |
| Carrillo-Alarcón, LC | 1 |
| Ponce-Monter, HA | 1 |
| Rangel-Flores, E | 1 |
| Loo-Estrada, JJ | 1 |
| Izquierdo-Vega, JA | 1 |
| Sánchez-Gutiérrez, M | 1 |
| Gerstenfeld, LC | 1 |
| Al-Ghawas, M | 1 |
| Alkhiary, YM | 1 |
| Cullinane, DM | 1 |
| Krall, EA | 1 |
| Fitch, JL | 1 |
| Webb, EG | 1 |
| Thiede, MA | 1 |
| Einhorn, TA | 1 |
| Eipe, N | 1 |
| Kay, J | 1 |
| DeAndrade, JR | 1 |
| Maslanka, M | 1 |
| Reines, HD | 1 |
| Howe, D | 1 |
| Rasmussen, GL | 1 |
| Cardea, J | 1 |
| Brown, J | 1 |
| Bynum, L | 1 |
| Shefrin, A | 1 |
| Chang, YL | 1 |
| Maneatis, T | 1 |
| Pierce, MC | 1 |
| Fuchs, S | 1 |
| Rainer, TH | 1 |
| Jacobs, P | 1 |
| Ng, YC | 1 |
| Cheung, NK | 1 |
| Tam, M | 1 |
| Lam, PK | 1 |
| Wong, R | 1 |
| Cocks, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Controlled Trial on Effectiveness of Ketorolac and Tramadol in Not Compound Fractures of Child[NCT00560443] | Phase 4 | 133 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Prospective, Randomized, Allocation-Concealed, Blinded Study Designed to Compare Ketorolac Sublingual and Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children[NCT02653742] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| A Randomized, Double-blinded, Placebo-controlled Study of Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy[NCT03453541] | Phase 4 | 600 participants (Anticipated) | Interventional | 2017-11-21 | Recruiting | ||
| Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections: a Prospective Double-Blinded Randomized Trial[NCT04895280] | Phase 4 | 400 participants (Anticipated) | Interventional | 2024-04-30 | Not yet recruiting | ||
| Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial[NCT04115644] | Phase 4 | 82 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Covid-19 and we failed to submit annual report for 2017 and 2018) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain as measured by the Visual Analog Scale after first injection. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Baseline - immediately after the injection
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.197 |
| Group 2 (Ketorolac) | 3.577 |
| Group 3 (Kenalog) | 3.677 |
Pain as measured by the Visual Analog Scale prior to first injection. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Baseline - pre-injection
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 5.77 |
| Group 2 (Ketorolac) | 4.57 |
| Group 3 (Kenalog) | 4.67 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Day 2
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 2.347 |
| Group 2 (Ketorolac) | 2.837 |
| Group 3 (Kenalog) | 2.67 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 1
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.397 |
| Group 2 (Ketorolac) | 3.7 |
| Group 3 (Kenalog) | 3.257 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 12
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.447 |
| Group 2 (Ketorolac) | 1.417 |
| Group 3 (Kenalog) | 2.027 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 2
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.547 |
| Group 2 (Ketorolac) | 2.67 |
| Group 3 (Kenalog) | 2.57 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 4
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.547 |
| Group 2 (Ketorolac) | 2.67 |
| Group 3 (Kenalog) | 2.317 |
Pain as measured by the Visual Analog Scale. The visual analog scale is a 0-10 scale, 0 being no pain, 10 being unbearable pain. (NCT04115644)
Timeframe: Week 6
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1 (Control) | 3.357 |
| Group 2 (Ketorolac) | 2.757 |
| Group 3 (Kenalog) | 2.687 |
5 trials available for ketorolac and Fractures, Bone
| Article | Year |
|---|---|
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial.
Topics: Administration, Sublingual; Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Effectiveness of diclofenac, ketorolac and etoricoxib in the treatment of acute pain from ankle fracture.
Topics: Acute Pain; Adult; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind | 2010 |
Ketorolac versus meperidine for pain relief after orthopaedic surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Bli | 1996 |
Evaluation of ketorolac in children with forearm fractures.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Prescho | 1997 |
Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit A | 2000 |
2 other studies available for ketorolac and Fractures, Bone
| Article | Year |
|---|---|
Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment.
Topics: Animals; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor | 2007 |
Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment.
Topics: Animals; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor | 2007 |
Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment.
Topics: Animals; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor | 2007 |
Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment.
Topics: Animals; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor | 2007 |
Spontaneously breathing technique for opioid tolerance.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhalation; Anti-Inflammatory | 2008 |