Page last updated: 2024-10-29
ketorolac and Fracture Malunion
ketorolac has been researched along with Fracture Malunion in 1 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "Ketorolac administered in the first 24 hours after fracture repair for acute pain management does not seem to have a negative impact on time to healing or incidence of nonunion for femoral or tibial shaft fractures." | 7.83 | Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures. ( Donohue, D; Gaskins, R; Jordan, C; Sagi, HC; Sanders, D; Sanders, R; Serrano-Riera, R, 2016) |
| "Ketorolac administered in the first 24 hours after fracture repair for acute pain management does not seem to have a negative impact on time to healing or incidence of nonunion for femoral or tibial shaft fractures." | 3.83 | Ketorolac Administered in the Recovery Room for Acute Pain Management Does Not Affect Healing Rates of Femoral and Tibial Fractures. ( Donohue, D; Gaskins, R; Jordan, C; Sagi, HC; Sanders, D; Sanders, R; Serrano-Riera, R, 2016) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Donohue, D | 1 |
| Sanders, D | 1 |
| Serrano-Riera, R | 1 |
| Jordan, C | 1 |
| Gaskins, R | 1 |
| Sanders, R | 1 |
| Sagi, HC | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| Effect of Toradol on Post-operative Foot and Ankle Healing[NCT03727048] | Phase 4 | 128 participants (Actual) | Interventional | 2016-08-31 | Completed |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Other Studies
1 other study available for ketorolac and Fracture Malunion