ketorolac has been researched along with Experimental Neoplasms in 1 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Preoperative, but not postoperative, administration of the nonsteroidal antiinflammatory drug ketorolac and/or resolvins, a family of specialized proresolving autacoid mediators, eliminated micrometastases in multiple tumor-resection models, resulting in long-term survival." | 3.91 | Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. ( Bhasin, M; Bhasin, SS; Bielenberg, DR; Chang, J; Fishbein, A; Gartung, A; Gilligan, MM; Hammock, BD; Huang, S; Kieran, MW; Panigrahy, D; Piwowarski, J; Schmidt, BA; Serhan, CN; Soler-Ferran, D; Sparks, MA; Staffa, SJ; Sukhatme, V; Sukhatme, VP; Sulciner, ML; Yang, H; Yang, J, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Panigrahy, D | 1 |
| Gartung, A | 1 |
| Yang, J | 1 |
| Yang, H | 1 |
| Gilligan, MM | 1 |
| Sulciner, ML | 1 |
| Bhasin, SS | 1 |
| Bielenberg, DR | 1 |
| Chang, J | 1 |
| Schmidt, BA | 1 |
| Piwowarski, J | 1 |
| Fishbein, A | 1 |
| Soler-Ferran, D | 1 |
| Sparks, MA | 1 |
| Staffa, SJ | 1 |
| Sukhatme, V | 1 |
| Hammock, BD | 1 |
| Kieran, MW | 1 |
| Huang, S | 1 |
| Bhasin, M | 1 |
| Serhan, CN | 1 |
| Sukhatme, VP | 1 |
1 other study available for ketorolac and Experimental Neoplasms
| Article | Year |
|---|---|
Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.
Topics: Animals; Docosahexaenoic Acids; Immunity, Cellular; Ketorolac; Male; Mice; Mice, Knockout; Neoplasm | 2019 |