ketorolac has been researched along with Exomphalos in 2 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This case report describes postoperative, reversible renal dysfunction and hypertension in a 5-year-old healthy boy after administration of relevant doses of ketorolac during anaesthesia." | 3.75 | [Ketorolac as a possible cause of reversible renal dysfunction in a 5-year-old child]. ( Knudsen, SM; Mantoni, T; Walther-Larsen, S, 2009) |
| "After umbilical hernia surgery, and wound infiltration with bupivacaine 0." | 2.68 | The effect of ketorolac as an adjuvant to local anaesthetic infiltration for analgesia in paediatric umbilical hernia surgery. ( Graham, SG; Wandless, JG, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knudsen, SM | 1 |
| Mantoni, T | 1 |
| Walther-Larsen, S | 1 |
| Graham, SG | 1 |
| Wandless, JG | 1 |
1 trial available for ketorolac and Exomphalos
| Article | Year |
|---|---|
The effect of ketorolac as an adjuvant to local anaesthetic infiltration for analgesia in paediatric umbilical hernia surgery.
Topics: Acetaminophen; Adjuvants, Anesthesia; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Anti- | 1995 |
1 other study available for ketorolac and Exomphalos
| Article | Year |
|---|---|
[Ketorolac as a possible cause of reversible renal dysfunction in a 5-year-old child].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Hernia, Umbilical; Humans; Hypertension; | 2009 |