Page last updated: 2024-10-29

ketorolac and Esophageal Neoplasms

ketorolac has been researched along with Esophageal Neoplasms in 6 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.

Research Excerpts

ExcerptRelevanceReference
"The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer."7.88Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018)
"The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer."3.88Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients. ( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018)
"Ketorolac was administered to 686 patients (67%); use was observed to increase over the study period from 49% in 2006 to 92% in 2016."1.62Ketorolac use and anastomotic leak in patients with esophageal cancer. ( Corsini, EM; Hofstetter, WL, 2021)
"It has the potential to reduce postoperative pain and use of nonsteroidal anti-inflammatory drugs, and to enhance recovery from surgery."1.48Outcomes of Transhiatal and Intercostal Pleural Drain After Ivor Lewis Esophagectomy: Comparative Analysis of Two Consecutive Patient Cohorts. ( Asti, E; Bernardi, D; Bonavina, L; Bonitta, G, 2018)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's3 (50.00)2.80

Authors

AuthorsStudies
Kwon, JH1
Denlinger, CE1
Corsini, EM1
Hofstetter, WL1
Groth, SS1
Fjederholt, KT1
Okholm, C1
Svendsen, LB1
Achiam, MP1
Kirkegård, J1
Mortensen, FV1
Asti, E1
Bernardi, D1
Bonitta, G1
Bonavina, L1
Jain, PN1
Shah, SC1

Other Studies

6 other studies available for ketorolac and Esophageal Neoplasms

ArticleYear
Commentary: Don't fear the nonsteroidal anti-inflammatory drugs.
    The Journal of thoracic and cardiovascular surgery, 2021, Volume: 161, Issue:2

    Topics: Anastomotic Leak; Anti-Inflammatory Agents; Esophageal Neoplasms; Humans; Ketorolac; Pharmaceutical

2021
Ketorolac use and anastomotic leak in patients with esophageal cancer.
    The Journal of thoracic and cardiovascular surgery, 2021, Volume: 161, Issue:2

    Topics: Adenocarcinoma; Aged; Anastomosis, Surgical; Anti-Inflammatory Agents, Non-Steroidal; Endoleak; Enha

2021
Commentary: Enhanced recovery after surgery: Does ketorolac get in the WAE of anastomotic healing following esophagectomy?
    The Journal of thoracic and cardiovascular surgery, 2021, Volume: 161, Issue:2

    Topics: Anastomosis, Surgical; Anastomotic Leak; Enhanced Recovery After Surgery; Esophageal Neoplasms; Esop

2021
Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018, Volume: 22, Issue:4

    Topics: Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Datab

2018
Outcomes of Transhiatal and Intercostal Pleural Drain After Ivor Lewis Esophagectomy: Comparative Analysis of Two Consecutive Patient Cohorts.
    Journal of laparoendoscopic & advanced surgical techniques. Part A, 2018, Volume: 28, Issue:5

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chest Tubes; Drainage; Esophageal Neoplasms; Esophage

2018
Respiratory depression following combination of epidural buprenorphine and intramuscular ketorolac.
    Anaesthesia, 1993, Volume: 48, Issue:10

    Topics: Analgesia, Epidural; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Depression,

1993