ketorolac has been researched along with Emesis, Postoperative in 18 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of ketorolac for pre-emptive analgesia is effective in patients undergoing retinal detachment surgery under general anesthesia." | 9.12 | Ketorolac as a pre-emptive analgesic in retinal detachment surgery: a prospective, randomized clinical trial. ( Sindjelic, R; Stefanovic, I; Vlajkovic, G, 2007) |
| "5% ketorolac eye drops at the start and end of strabismus repair surgery." | 9.10 | Amethocaine or ketorolac eyedrops provide inadequate analgesia in pediatric strabismus surgery. ( Azavedo, L; Bhananker, S; Bonn, G; Kim, J; Splinter, W, 2003) |
| "To determine the efficacy of oral granisetron in preventing postoperative vomiting (POV) following strabismus repair in children." | 9.09 | Oral granisetron for strabismus surgery in children. ( D'Errico, CC; Lauder, GR; Munro, HM; Tait, AR; Voepel-Lewis, T; Wagner, DS, 1999) |
| "The use of ketorolac for pre-emptive analgesia is effective in patients undergoing retinal detachment surgery under general anesthesia." | 5.12 | Ketorolac as a pre-emptive analgesic in retinal detachment surgery: a prospective, randomized clinical trial. ( Sindjelic, R; Stefanovic, I; Vlajkovic, G, 2007) |
| "5% ketorolac eye drops at the start and end of strabismus repair surgery." | 5.10 | Amethocaine or ketorolac eyedrops provide inadequate analgesia in pediatric strabismus surgery. ( Azavedo, L; Bhananker, S; Bonn, G; Kim, J; Splinter, W, 2003) |
| "To determine the efficacy of oral granisetron in preventing postoperative vomiting (POV) following strabismus repair in children." | 5.09 | Oral granisetron for strabismus surgery in children. ( D'Errico, CC; Lauder, GR; Munro, HM; Tait, AR; Voepel-Lewis, T; Wagner, DS, 1999) |
| "We convened a multidisciplinary team to develop a postoperative nausea and vomiting prophylaxis guideline which included administration of dexamethasone, ondansetron, and a low-dose propofol infusion in addition to a femoral and sciatic nerve block and routine ketorolac administration for pain control." | 3.96 | Reducing postoperative nausea and vomiting in pediatric patients undergoing anterior cruciate ligament reconstruction: A quality report. ( Browne, P; Galvez, J; Ganley, T; Gurnaney, HG; Jantzen, E; Keren, R; Kerr, J; Kraemer, FW; Muhly, WT; Wells, L, 2020) |
| "Ketorolac was the least immunosuppressive among the 3 drugs." | 2.82 | Comparison Between the Effects of Intravenous Morphine, Tramadol, and Ketorolac on Stress and Immune Responses in Patients Undergoing Modified Radical Mastectomy. ( Abd El-Rahman, AM; Amr, SA; Bakr, MA; El Sherif, FA; Hamed, HB; Mohamed, SA; Mostafa, MA, 2016) |
| "All patients were assessed for postoperative nausea and vomiting by a blinded research nurse." | 2.80 | A Randomized Controlled Trial of Oral Versus Intravenous Administration of a Nonnarcotic Analgesia Protocol Following Pediatric Craniosynostosis Corrections on Nausea and Vomiting Rates. ( Dimas, V; Ditthakasem, K; Fearon, JA; Herbert, MA, 2015) |
| "Postoperative pain and postoperative nausea and vomiting (PONV) were assessed via a visual analog scale." | 2.79 | Efficacy of continuous wound infiltration of local anesthetic for pain relief after gynecologic laparoscopy. ( Cheong, JY; Kong, TW; Min, SK; Park, H; Ryu, HS, 2014) |
| "Ketorolac was more effective in reducing the frequency of bladder spasms and rescue analgesic requirements." | 2.76 | Ketorolac or fentanyl continuous infusion for post-operative analgesia in children undergoing ureteroneocystostomy. ( Choi, EK; Hong, JY; Jo, YY; Kil, HK, 2011) |
| "However, postoperative nausea and vomiting was significantly lower in groups II and III (p < 0." | 2.73 | Postoperative intravenous patient-controlled analgesia in thyroid surgery: comparison of fentanyl and ondansetron regimens with and without the nonsteriodal anti-inflammatory drug ketorolac. ( Chang, DJ; Kim, EM; Kim, KJ; Kim, SY; Nam, KH; Nam, SH, 2008) |
| "The ketorolac patients were significantly faster for ready discharge, median 165 min vs." | 2.73 | Analgesic and antiemetic effect of ketorolac vs. betamethasone or dexamethasone after ambulatory surgery. ( Jensen, HH; Raeder, J; Thagaard, KS, 2007) |
| "In this retrospective analysis of 10,575 patients who used fentanyl-based intravenous patient-controlled analgesia (IV-PCA) after surgery, we evaluated difference between young and elderly patients on their characteristic of adverse effects." | 1.42 | Postoperative Pain and Intravenous Patient-Controlled Analgesia-Related Adverse Effects in Young and Elderly Patients: A Retrospective Analysis of 10,575 Patients. ( Choi, S; Han, DW; Kim, SY; Koh, JC; Lee, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Gaballah, KM | 1 |
| Habeeb, RM | 1 |
| Abdallah, SI | 1 |
| Muhly, WT | 1 |
| Ganley, T | 1 |
| Jantzen, E | 1 |
| Browne, P | 1 |
| Kerr, J | 1 |
| Gurnaney, HG | 1 |
| Kraemer, FW | 1 |
| Galvez, J | 1 |
| Keren, R | 1 |
| Wells, L | 1 |
| Kong, TW | 1 |
| Park, H | 1 |
| Cheong, JY | 1 |
| Min, SK | 1 |
| Ryu, HS | 1 |
| Tietje, T | 1 |
| Davis, AB | 1 |
| Rivey, MP | 1 |
| Fearon, JA | 1 |
| Dimas, V | 1 |
| Ditthakasem, K | 1 |
| Herbert, MA | 1 |
| Koh, JC | 1 |
| Lee, J | 1 |
| Kim, SY | 2 |
| Choi, S | 1 |
| Han, DW | 1 |
| Bakr, MA | 1 |
| Amr, SA | 1 |
| Mohamed, SA | 1 |
| Hamed, HB | 1 |
| Abd El-Rahman, AM | 1 |
| Mostafa, MA | 1 |
| El Sherif, FA | 1 |
| Kim, EM | 1 |
| Nam, KH | 1 |
| Chang, DJ | 1 |
| Nam, SH | 1 |
| Kim, KJ | 1 |
| Jo, YY | 1 |
| Hong, JY | 1 |
| Choi, EK | 1 |
| Kil, HK | 1 |
| Kim, J | 1 |
| Azavedo, L | 1 |
| Bhananker, S | 1 |
| Bonn, G | 1 |
| Splinter, W | 1 |
| Keidan, I | 1 |
| Zaslansky, R | 1 |
| Eviatar, E | 1 |
| Segal, S | 1 |
| Sarfaty, SM | 1 |
| Vintar, N | 1 |
| Rawal, N | 1 |
| Veselko, M | 1 |
| Ali, A | 1 |
| Chohan, U | 1 |
| Atiq, F | 1 |
| Thagaard, KS | 1 |
| Jensen, HH | 1 |
| Raeder, J | 1 |
| Vlajkovic, G | 1 |
| Sindjelic, R | 1 |
| Stefanovic, I | 1 |
| Munro, HM | 1 |
| D'Errico, CC | 1 |
| Lauder, GR | 1 |
| Wagner, DS | 1 |
| Voepel-Lewis, T | 1 |
| Tait, AR | 1 |
| Peng, P | 1 |
| Claxton, A | 1 |
| Chung, F | 1 |
| Chan, V | 1 |
| Miniaci, A | 1 |
| Krishnathas, A | 1 |
| Bridge, HS | 1 |
| Montgomery, CJ | 1 |
| Kennedy, RA | 1 |
| Merrick, PM | 1 |
15 trials available for ketorolac and Emesis, Postoperative
| Article | Year |
|---|---|
Efficacy of intraperitoneal bupivacaine, hydrocortisone, and magnesium sulfate in different combinations for pain relief after laparoscopic ovarian cystectomy: a double-blind randomized controlled trial.
Topics: Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Double-Blind Method; F | 2020 |
Efficacy of continuous wound infiltration of local anesthetic for pain relief after gynecologic laparoscopy.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Female; Fentan | 2014 |
A Randomized Controlled Trial of Oral Versus Intravenous Administration of a Nonnarcotic Analgesia Protocol Following Pediatric Craniosynostosis Corrections on Nausea and Vomiting Rates.
Topics: Acetaminophen; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Anesthesia Recovery Perio | 2015 |
Comparison Between the Effects of Intravenous Morphine, Tramadol, and Ketorolac on Stress and Immune Responses in Patients Undergoing Modified Radical Mastectomy.
Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Hum | 2016 |
Postoperative intravenous patient-controlled analgesia in thyroid surgery: comparison of fentanyl and ondansetron regimens with and without the nonsteriodal anti-inflammatory drug ketorolac.
Topics: Adult; Analgesia, Patient-Controlled; Anti-Inflammatory Agents, Non-Steroidal; Dizziness; Female; Fe | 2008 |
Ketorolac or fentanyl continuous infusion for post-operative analgesia in children undergoing ureteroneocystostomy.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Cystostomy; Double-Bl | 2011 |
Amethocaine or ketorolac eyedrops provide inadequate analgesia in pediatric strabismus surgery.
Topics: Anesthesia, Local; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Presch | 2003 |
Intraoperative ketorolac is an effective substitute for fentanyl in children undergoing outpatient adenotonsillectomy.
Topics: Adenoidectomy; Ambulatory Surgical Procedures; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2004 |
Intraarticular patient-controlled regional anesthesia after arthroscopically assisted anterior cruciate ligament reconstruction: ropivacaine/morphine/ketorolac versus ropivacaine/morphine.
Topics: Adolescent; Adult; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Conduction | 2005 |
Intravenous tramadol vs ketorolac in laparoscopic dye test.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; | 2006 |
Analgesic and antiemetic effect of ketorolac vs. betamethasone or dexamethasone after ambulatory surgery.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics; Anesthesia, General; Antiemetics; Betamethasone; | 2007 |
Ketorolac as a pre-emptive analgesic in retinal detachment surgery: a prospective, randomized clinical trial.
Topics: Analgesics; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal | 2007 |
Oral granisetron for strabismus surgery in children.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Antiemetics; | 1999 |
Femoral nerve block and ketorolac in patients undergoing anterior cruciate ligament reconstruction.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anterior Cruciate Ligament; Anti-Inflammatory Agents, | 1999 |
Analgesic efficacy of ketorolac 0.5% ophthalmic solution (Accular) in paediatric strabismus surgery.
Topics: Child; Child, Preschool; Double-Blind Method; Female; Humans; Ketorolac; Male; Ophthalmic Solutions; | 2000 |
3 other studies available for ketorolac and Emesis, Postoperative
| Article | Year |
|---|---|
Reducing postoperative nausea and vomiting in pediatric patients undergoing anterior cruciate ligament reconstruction: A quality report.
Topics: Adolescent; Anterior Cruciate Ligament Reconstruction; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2020 |
Comparison of 2 Methods of Local Anesthetic-Based Injection as Part of a Multimodal Approach to Pain Management After Total Knee Arthroplasty.
Topics: Aged; Amides; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, | 2015 |
Postoperative Pain and Intravenous Patient-Controlled Analgesia-Related Adverse Effects in Young and Elderly Patients: A Retrospective Analysis of 10,575 Patients.
Topics: Adult; Age Factors; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agent | 2015 |