ketorolac has been researched along with Disc, Herniated in 4 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pre- and postoperative pain was assessed by using a standard scale and was correlated to postoperative MSO4 demand by Pearson correlation." | 2.70 | Postoperative narcotic requirement after microscopic lumbar discectomy is not affected by intraoperative ketorolac or bupivacaine. ( Hass, D; Lavyne, MH; Lien, CA; Mack, PF; Snow, RB, 2001) |
| "Ketorolac was delivered through a device for patient controlled analgesia after surgery." | 2.70 | [Bupivacaine in continuous epidural infusion using a portable mechanical devise for postoperative analgesia after surgery for hernia of the lumbar disk]. ( Burguillos López, S; Hernández-Palazón, J; Martínez-Pérez, M; Piqueras-Pérez, C; Tortosa Serrano, JA, 2001) |
| "Ketorolac was no better than the other analgesics studied but was associated with a higher number of mild side effects." | 2.68 | [Postoperative analgesia in herniated disk surgery. Comparative study of diclofenac , lysine acetylsalicylate, and ketorolac]. ( Fábregas, N; Izquierdo, E; Nalda, MA; Salvador, L; Soley, R; Valero, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Izquierdo, E | 1 |
| Fábregas, N | 1 |
| Valero, R | 1 |
| Salvador, L | 1 |
| Soley, R | 1 |
| Nalda, MA | 1 |
| Hernández-Palazón, J | 2 |
| Tortosa Serrano, JA | 2 |
| Burguillos López, S | 2 |
| Molero Molero, E | 1 |
| Mack, PF | 1 |
| Hass, D | 1 |
| Lavyne, MH | 1 |
| Snow, RB | 1 |
| Lien, CA | 1 |
| Martínez-Pérez, M | 1 |
| Piqueras-Pérez, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative, Randomized Trial of SPI-directed Intravenous Analgesia Using Metamizole With Tramadol Versus Preemptive Wound Infiltration Using 0,2 % Ropivacaine With Fentanyl or 0,2 % Bupivacaine With Fentanyl for Lumbar Discectomy[NCT02971540] | 132 participants (Actual) | Interventional | 2016-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for ketorolac and Disc, Herniated
| Article | Year |
|---|---|
[Postoperative analgesia in herniated disk surgery. Comparative study of diclofenac , lysine acetylsalicylate, and ketorolac].
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Diskectomy; Female; | 1995 |
[Infiltration of the surgical wound with local anesthetic for postoperative analgesia in patients operated on for lumbar disc herniation. Comparative study of ropivacaine and bupivacaine].
Topics: Adult; Amides; Analgesia; Analgesia, Patient-Controlled; Anesthesia, Local; Anesthetics, Local; Bupi | 2001 |
Postoperative narcotic requirement after microscopic lumbar discectomy is not affected by intraoperative ketorolac or bupivacaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; | 2001 |
[Bupivacaine in continuous epidural infusion using a portable mechanical devise for postoperative analgesia after surgery for hernia of the lumbar disk].
Topics: Adult; Anesthesia, Epidural; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain | 2001 |