ketorolac has been researched along with Constricted Pupil in 7 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0." | 9.20 | The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery. ( Chung, BH; Jung, JW; Kim, EK; Kim, TI; Seo, KY, 2015) |
| "Topical ketorolac was a more effective inhibitor of miosis than topical diclofenac during extracapsular cataract extraction and IOL implantation." | 9.10 | Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. ( Srinivasan, R, 2002) |
| "A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0." | 5.20 | The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery. ( Chung, BH; Jung, JW; Kim, EK; Kim, TI; Seo, KY, 2015) |
| "Topical ketorolac was a more effective inhibitor of miosis than topical diclofenac during extracapsular cataract extraction and IOL implantation." | 5.10 | Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. ( Srinivasan, R, 2002) |
| "Men treated with tamsulosin having standard cataract extraction surgery were placed in a treatment group that received phenylephrine 1." | 2.87 | Effect of phenylephrine 1.0%-ketorolac 0.3% injection on tamsulosin-associated intraoperative floppy-iris syndrome. ( Juzych, MS; Nariman, N; Pankratz, J; Rana, S; Rana, VK; Segars, L; Silverstein, SM; Stephens, R, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silverstein, SM | 1 |
| Rana, VK | 1 |
| Stephens, R | 1 |
| Segars, L | 1 |
| Pankratz, J | 1 |
| Rana, S | 1 |
| Juzych, MS | 1 |
| Nariman, N | 1 |
| Walter, K | 1 |
| Delwadia, N | 1 |
| Coben, J | 1 |
| Sullivan-Mackenna, D | 1 |
| Roberts, H | 1 |
| O'Brart, D | 1 |
| Walter, KA | 1 |
| Jung, JW | 1 |
| Chung, BH | 1 |
| Kim, EK | 1 |
| Seo, KY | 1 |
| Kim, TI | 1 |
| Chatterjee, S | 1 |
| Srinivasan, R | 1 |
3 trials available for ketorolac and Constricted Pupil
| Article | Year |
|---|---|
Effect of phenylephrine 1.0%-ketorolac 0.3% injection on tamsulosin-associated intraoperative floppy-iris syndrome.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Aged; Aged, 80 and ov | 2018 |
The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Cataract; Cataract Extr | 2015 |
Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; D | 2002 |
4 other studies available for ketorolac and Constricted Pupil
| Article | Year |
|---|---|
Continuous intracameral phenylephrine-ketorolac irrigation for miosis prevention in femtosecond laser-assisted cataract surgery: Reduction in surgical time and iris manipulation.
Topics: Adrenergic alpha-1 Receptor Agonists; Aged; Aged, 80 and over; Anterior Chamber; Cataract Extraction | 2019 |
Reduction in surgical time and iris manipulation using continuous intracameral irrigation of phenylephrine and ketorolac to prevent miosis in FLACS.
Topics: Cataract; Humans; Iris; Ketorolac; Miosis; Operative Time; Phenylephrine | 2019 |
Reply.
Topics: Cataract; Humans; Iris; Ketorolac; Miosis; Operative Time; Phenylephrine | 2019 |
Preventing perioperative miosis in cataract surgery.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ketorolac; Miosis; Myd | 2003 |