ketorolac has been researched along with Conjunctivitis, Allergic in 9 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Conjunctivitis, Allergic: Conjunctivitis due to hypersensitivity to various allergens.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emedastine is superior to ketorolac in controlling itching and redness, the cardinal symptom and sign of allergic conjunctivitis." | 9.09 | Comparison of the topical ocular antiallergic efficacy of emedastine 0.05% ophthalmic solution to ketorolac 0.5% ophthalmic solution in a clinical model of allergic conjunctivitis. ( Abelson, M; Deschenes, J; Discepola, M, 1999) |
| "Emedastine is superior to ketorolac in controlling itching and redness, the cardinal symptom and sign of allergic conjunctivitis." | 5.09 | Comparison of the topical ocular antiallergic efficacy of emedastine 0.05% ophthalmic solution to ketorolac 0.5% ophthalmic solution in a clinical model of allergic conjunctivitis. ( Abelson, M; Deschenes, J; Discepola, M, 1999) |
| "The study demonstrated that olopatadine is effective and safe in preventing and treating ocular itching and hyperemia associated with acute allergic conjunctivitis and is more effective and more comfortable than ketorolac." | 5.09 | Comparative evaluation of olopatadine ophthalmic solution (0.1%) versus ketorolac ophthalmic solution (0.5%) using the provocative antigen challenge model. ( Abelson, M; Deschenes, J; Discepola, M, 1999) |
| "The therapeutic utility of cyclooxygenase (CO) inhibitors, such as ketorolac, in reducing the inflammatory events associated with allergic conjunctivitis is not unexpected since prostanoids (PG) elicit conjunctival redness (PGD2, PGE2, PGF2 alpha), edema (PGD2, TxA2), eosinophil infiltration (PGD2, PGJ2) and mucous cell discharge (PGD2, PGJ2, TxA2)." | 3.69 | The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. ( Hawley, SB; Joseph, R; Merlino, GF; Nieves, AL; Spada, CS; Woodward, DF, 1995) |
| "Topically administered ketorolac (Acular), a cyclooxygenase inhibitor, has recently been reported as clinically beneficial for treating allergic conjunctivitis." | 3.69 | Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching. ( Friedlaender, MH; Nieves, AL; Woodward, DF, 1996) |
| " In this single-center, 7-day, prospective, double-blind, single-dose, crossover, parallel-group study, subjects were randomized to be bilaterally dosed with pemirolast, cromolyn, or ketorolac at each of 3 visits." | 2.71 | A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents. ( Amdahl, L; Graves, A; Shulman, DG; Washington, C, 2003) |
| "Ketorolac treated eyes showed 50." | 2.68 | Topical ketorolac 0.5% solution for the treatment of vernal keratoconjunctivitis. ( Gupta, A; Gupta, R; Ram, J; Sharma, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Celik, T | 1 |
| Turkoglu, EB | 1 |
| Shulman, DG | 1 |
| Amdahl, L | 1 |
| Washington, C | 1 |
| Graves, A | 1 |
| Holdcroft, C | 1 |
| Meijer, F | 1 |
| Ruijter, JM | 1 |
| Van Delft, JL | 1 |
| Van Haeringen, NJ | 1 |
| Woodward, DF | 2 |
| Nieves, AL | 2 |
| Hawley, SB | 1 |
| Joseph, R | 1 |
| Merlino, GF | 1 |
| Spada, CS | 1 |
| Friedlaender, MH | 1 |
| Sharma, A | 1 |
| Gupta, R | 1 |
| Ram, J | 1 |
| Gupta, A | 1 |
| Discepola, M | 2 |
| Deschenes, J | 2 |
| Abelson, M | 2 |
5 trials available for ketorolac and Conjunctivitis, Allergic
| Article | Year |
|---|---|
Comparative evaluation of olopatadine 0.01% combined fluorometholone 0.1% treatment versus olopatadine 0.01% combined ketorolac 0.4% treatment in patients with acute seasonal allergic conjunctivitis.
Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; | 2014 |
A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents.
Topics: Administration, Topical; Adult; Anti-Allergic Agents; Conjunctivitis, Allergic; Cromolyn Sodium; Dou | 2003 |
Topical ketorolac 0.5% solution for the treatment of vernal keratoconjunctivitis.
Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, P | 1997 |
Comparison of the topical ocular antiallergic efficacy of emedastine 0.05% ophthalmic solution to ketorolac 0.5% ophthalmic solution in a clinical model of allergic conjunctivitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Conjunctivitis, Allergic; Cross-Over Studie | 1999 |
Comparative evaluation of olopatadine ophthalmic solution (0.1%) versus ketorolac ophthalmic solution (0.5%) using the provocative antigen challenge model.
Topics: Acute Disease; Adult; Aged; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Alle | 1999 |
4 other studies available for ketorolac and Conjunctivitis, Allergic
| Article | Year |
|---|---|
Ketorolac: a new antiinflammatory for seasonal allergic conjunctivitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; Humans; Ketorolac; Ophthalmic Sol | 1994 |
Nitric oxide induces vascular permeability changes in the guinea pig conjunctiva.
Topics: Albumins; Animals; Arginine; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Enzyme I | 1995 |
The pruritogenic and inflammatory effects of prostanoids in the conjunctiva.
Topics: Animals; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Cyclooxygenase Inhibitors; D | 1995 |
Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching.
Topics: Animals; Conjunctivitis, Allergic; Female; Guinea Pigs; Ketorolac; Male; Prostaglandins; Pruritus; R | 1996 |