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ketorolac and Conjunctivitis, Allergic

ketorolac has been researched along with Conjunctivitis, Allergic in 9 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Conjunctivitis, Allergic: Conjunctivitis due to hypersensitivity to various allergens.

Research Excerpts

ExcerptRelevanceReference
"Emedastine is superior to ketorolac in controlling itching and redness, the cardinal symptom and sign of allergic conjunctivitis."9.09Comparison of the topical ocular antiallergic efficacy of emedastine 0.05% ophthalmic solution to ketorolac 0.5% ophthalmic solution in a clinical model of allergic conjunctivitis. ( Abelson, M; Deschenes, J; Discepola, M, 1999)
"Emedastine is superior to ketorolac in controlling itching and redness, the cardinal symptom and sign of allergic conjunctivitis."5.09Comparison of the topical ocular antiallergic efficacy of emedastine 0.05% ophthalmic solution to ketorolac 0.5% ophthalmic solution in a clinical model of allergic conjunctivitis. ( Abelson, M; Deschenes, J; Discepola, M, 1999)
"The study demonstrated that olopatadine is effective and safe in preventing and treating ocular itching and hyperemia associated with acute allergic conjunctivitis and is more effective and more comfortable than ketorolac."5.09Comparative evaluation of olopatadine ophthalmic solution (0.1%) versus ketorolac ophthalmic solution (0.5%) using the provocative antigen challenge model. ( Abelson, M; Deschenes, J; Discepola, M, 1999)
"The therapeutic utility of cyclooxygenase (CO) inhibitors, such as ketorolac, in reducing the inflammatory events associated with allergic conjunctivitis is not unexpected since prostanoids (PG) elicit conjunctival redness (PGD2, PGE2, PGF2 alpha), edema (PGD2, TxA2), eosinophil infiltration (PGD2, PGJ2) and mucous cell discharge (PGD2, PGJ2, TxA2)."3.69The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. ( Hawley, SB; Joseph, R; Merlino, GF; Nieves, AL; Spada, CS; Woodward, DF, 1995)
"Topically administered ketorolac (Acular), a cyclooxygenase inhibitor, has recently been reported as clinically beneficial for treating allergic conjunctivitis."3.69Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching. ( Friedlaender, MH; Nieves, AL; Woodward, DF, 1996)
" In this single-center, 7-day, prospective, double-blind, single-dose, crossover, parallel-group study, subjects were randomized to be bilaterally dosed with pemirolast, cromolyn, or ketorolac at each of 3 visits."2.71A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents. ( Amdahl, L; Graves, A; Shulman, DG; Washington, C, 2003)
"Ketorolac treated eyes showed 50."2.68Topical ketorolac 0.5% solution for the treatment of vernal keratoconjunctivitis. ( Gupta, A; Gupta, R; Ram, J; Sharma, A, 1997)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (77.78)18.2507
2000's1 (11.11)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Celik, T1
Turkoglu, EB1
Shulman, DG1
Amdahl, L1
Washington, C1
Graves, A1
Holdcroft, C1
Meijer, F1
Ruijter, JM1
Van Delft, JL1
Van Haeringen, NJ1
Woodward, DF2
Nieves, AL2
Hawley, SB1
Joseph, R1
Merlino, GF1
Spada, CS1
Friedlaender, MH1
Sharma, A1
Gupta, R1
Ram, J1
Gupta, A1
Discepola, M2
Deschenes, J2
Abelson, M2

Trials

5 trials available for ketorolac and Conjunctivitis, Allergic

ArticleYear
Comparative evaluation of olopatadine 0.01% combined fluorometholone 0.1% treatment versus olopatadine 0.01% combined ketorolac 0.4% treatment in patients with acute seasonal allergic conjunctivitis.
    Current eye research, 2014, Volume: 39, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic;

2014
A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents.
    Clinical therapeutics, 2003, Volume: 25, Issue:4

    Topics: Administration, Topical; Adult; Anti-Allergic Agents; Conjunctivitis, Allergic; Cromolyn Sodium; Dou

2003
Topical ketorolac 0.5% solution for the treatment of vernal keratoconjunctivitis.
    Indian journal of ophthalmology, 1997, Volume: 45, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, P

1997
Comparison of the topical ocular antiallergic efficacy of emedastine 0.05% ophthalmic solution to ketorolac 0.5% ophthalmic solution in a clinical model of allergic conjunctivitis.
    Acta ophthalmologica Scandinavica. Supplement, 1999, Issue:228

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Conjunctivitis, Allergic; Cross-Over Studie

1999
Comparative evaluation of olopatadine ophthalmic solution (0.1%) versus ketorolac ophthalmic solution (0.5%) using the provocative antigen challenge model.
    Acta ophthalmologica Scandinavica. Supplement, 1999, Issue:228

    Topics: Acute Disease; Adult; Aged; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Alle

1999

Other Studies

4 other studies available for ketorolac and Conjunctivitis, Allergic

ArticleYear
Ketorolac: a new antiinflammatory for seasonal allergic conjunctivitis.
    The Nurse practitioner, 1994, Volume: 19, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; Humans; Ketorolac; Ophthalmic Sol

1994
Nitric oxide induces vascular permeability changes in the guinea pig conjunctiva.
    European journal of pharmacology, 1995, Sep-15, Volume: 284, Issue:1-2

    Topics: Albumins; Animals; Arginine; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Enzyme I

1995
The pruritogenic and inflammatory effects of prostanoids in the conjunctiva.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Fall, Volume: 11, Issue:3

    Topics: Animals; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Cyclooxygenase Inhibitors; D

1995
Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:1

    Topics: Animals; Conjunctivitis, Allergic; Female; Guinea Pigs; Ketorolac; Male; Prostaglandins; Pruritus; R

1996