ketorolac has been researched along with Complication, Intraoperative in 9 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of intraoperative shoulder pain in the control group was significantly higher than the ketorolac group (P = 0." | 9.24 | Pre-emptive ketorolac for prevention of intraoperative shoulder pain in patients undergoing cesarean section: A double blind randomized clinical trial. ( Abbas, MS; Abdel Aleem, AA; Askar, OA, 2017) |
| "Topical ketorolac tromethamine usage is no more effective than artificial tears for pain relief during posterior segment laser procedures in proliferative diabetic retinopathy patients." | 9.12 | Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser. ( Esgin, H; Samut, HS, 2006) |
| "The incidence of intraoperative shoulder pain in the control group was significantly higher than the ketorolac group (P = 0." | 5.24 | Pre-emptive ketorolac for prevention of intraoperative shoulder pain in patients undergoing cesarean section: A double blind randomized clinical trial. ( Abbas, MS; Abdel Aleem, AA; Askar, OA, 2017) |
| "Topical ketorolac tromethamine usage is no more effective than artificial tears for pain relief during posterior segment laser procedures in proliferative diabetic retinopathy patients." | 5.12 | Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser. ( Esgin, H; Samut, HS, 2006) |
| "Men treated with tamsulosin having standard cataract extraction surgery were placed in a treatment group that received phenylephrine 1." | 2.87 | Effect of phenylephrine 1.0%-ketorolac 0.3% injection on tamsulosin-associated intraoperative floppy-iris syndrome. ( Juzych, MS; Nariman, N; Pankratz, J; Rana, S; Rana, VK; Segars, L; Silverstein, SM; Stephens, R, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diakonis, VF | 1 |
| Kontadakis, GA | 1 |
| Anagnostopoulos, AG | 1 |
| Yesilirmak, N | 1 |
| Waren, DP | 1 |
| Cabot, F | 1 |
| Yoo, SH | 1 |
| Donaldson, KE | 1 |
| Abbas, MS | 1 |
| Askar, OA | 1 |
| Abdel Aleem, AA | 1 |
| Silverstein, SM | 1 |
| Rana, VK | 1 |
| Stephens, R | 1 |
| Segars, L | 1 |
| Pankratz, J | 1 |
| Rana, S | 1 |
| Juzych, MS | 1 |
| Nariman, N | 1 |
| Bugada, D | 1 |
| Lavand'homme, P | 1 |
| Ambrosoli, AL | 1 |
| Cappelleri, G | 1 |
| Saccani Jotti, GM | 1 |
| Meschi, T | 1 |
| Fanelli, G | 1 |
| Allegri, M | 1 |
| Medina-Vera, AJ | 1 |
| Novoa, LM | 1 |
| Esgin, H | 1 |
| Samut, HS | 1 |
| Ignjatovic, D | 1 |
| Reuben, SS | 1 |
| Steinberg, RB | 1 |
| Kreitzer, JM | 1 |
| Duprat, KM | 1 |
| Williams, EL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preemptive Ketorolac for Intraoperative Shoulder Tip Pain During Cesarean Section: A Double-Blind Randomized Clinical Trial.[NCT02380898] | Phase 4 | 200 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for ketorolac and Complication, Intraoperative
| Article | Year |
|---|---|
Effects of Short-term Preoperative Topical Ketorolac on Pupil Diameter in Eyes Undergoing Femtosecond Laser-Assisted Capsulotomy.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dose-Resp | 2017 |
Pre-emptive ketorolac for prevention of intraoperative shoulder pain in patients undergoing cesarean section: A double blind randomized clinical trial.
Topics: Adult; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Double-Blind M | 2017 |
Effect of phenylephrine 1.0%-ketorolac 0.3% injection on tamsulosin-associated intraoperative floppy-iris syndrome.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Aged; Aged, 80 and ov | 2018 |
Reduced anaesthetic requirements and postoperative analgesics in patients undergoing laparoscopic cholecystectomy: premedication with intravenous paracetamol versus ketorolac, a double blind and randomised clinical trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Inhalation; Anesthe | 2017 |
Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Retinopathy; | 2006 |
Intravenous regional anesthesia using lidocaine and ketorolac.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla | 1995 |
3 other studies available for ketorolac and Complication, Intraoperative
| Article | Year |
|---|---|
Effect of Preoperative Inflammatory Status and Comorbidities on Pain Resolution and Persistent Postsurgical Pain after Inguinal Hernia Repair.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pai | 2016 |
Comment to: Vuilleumier H, Halkic N. Ruptured subcapsular hematoma after laparoscopic cholecystectomy attributed to ketorolac-induced coagulopathy. Surg Endosc 2006, online first.
Topics: Blood Coagulation; Cholecystectomy, Laparoscopic; Follow-Up Studies; Gastrointestinal Hemorrhage; He | 2007 |
Ketorolac appears to decrease polyuria during intracranial surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Craniotomy; Female; Humans; Intraoperative Complicat | 1996 |