ketorolac has been researched along with Cleft Palate, Isolated in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the efficacy and safety profile of ketorolac in cleft palate surgery." | 8.12 | Postoperative Use of Ketorolac Improves Pain Management and Decreases Narcotic Use Following Primary Cleft Palate Surgery. ( Dudley, S; Frederick, R; Spence, M; Stocks, R, 2022) |
| "To study the efficacy and safety profile of ketorolac in cleft palate surgery." | 4.12 | Postoperative Use of Ketorolac Improves Pain Management and Decreases Narcotic Use Following Primary Cleft Palate Surgery. ( Dudley, S; Frederick, R; Spence, M; Stocks, R, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dudley, S | 1 |
| Spence, M | 1 |
| Frederick, R | 1 |
| Stocks, R | 1 |
| Ganske, IM | 1 |
| Langa, OC | 1 |
| Cappitelli, AT | 1 |
| Nuzzi, LC | 1 |
| Staffa, SJ | 1 |
| DiTullio, N | 1 |
| Fullerton, Z | 1 |
| Alrayashi, W | 1 |
| Meara, JG | 1 |
| Rogers-Vizena, CR | 1 |
| Cepeda, A | 1 |
| Johnson, ML | 1 |
| Kelagere, K | 1 |
| Obinero, CG | 1 |
| Nguyen, PD | 1 |
| Greives, MR | 1 |
| Stein, JR | 1 |
| Mantilla-Rivas, E | 1 |
| Aivaz, M | 1 |
| Rana, MS | 1 |
| Mamidi, IS | 1 |
| Ichiuji, BA | 1 |
| Manrique, M | 1 |
| Rogers, GF | 1 |
| Finkel, JC | 1 |
| Oh, AK | 1 |
| Hayes, JA | 1 |
| Forrest, CR | 1 |
| Walsh, W | 1 |
| Pétroz, GC | 1 |
| Adeli, K | 1 |
| Bissonnette, B | 1 |
| Dawson, KH | 1 |
| Egbert, MA | 1 |
| Myall, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effectiveness of Bupivicaine Infusion Versus Intravenous Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting for Lefort I Osteotomy or Alveolar Cleft Repair.[NCT00405262] | Phase 3 | 54 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for ketorolac and Cleft Palate, Isolated
| Article | Year |
|---|---|
Continuous bupivacaine infusion post-iliac crest bone graft harvesting in pediatric cleft surgery: role and comparison with ketorolac.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bone Tr | 2011 |
Pain following iliac crest bone grafting of alveolar clefts.
Topics: Age Factors; Alveolar Process; Alveoloplasty; Analgesia, Patient-Controlled; Analgesics, Non-Narcoti | 1996 |
4 other studies available for ketorolac and Cleft Palate, Isolated
| Article | Year |
|---|---|
Postoperative Use of Ketorolac Improves Pain Management and Decreases Narcotic Use Following Primary Cleft Palate Surgery.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Cleft Palate; Humans; Ketorolac; | 2022 |
Perioperative Pain Management After Primary Palate Repair: A 3-Surgeon Retrospective Study.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Cleft Palate; Dexamethasone; Humans; Ketorolac; | 2023 |
The Limit Is Zero: A Prospective Evaluation of Ketorolac in Patients Undergoing Primary Palatoplasty to Reduce Narcotic Utilization.
Topics: Cleft Palate; Cohort Studies; Humans; Ketorolac; Length of Stay; Morphine Derivatives; Narcotics; Pa | 2023 |
Safety and Efficacy of Single-Dose Ketorolac for Postoperative Pain Management After Primary Palatoplasty: A Prospective Cohort Study With Historical Controls.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Cleft Palate; Double-Blind Metho | 2022 |