ketorolac has been researched along with Chronic Disease in 10 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate whether ketorolac ophthalmic drops prescribed four times a day can be associated with improved visual acuity and prompt resolution of edema for patients with pseudophakic cystoid macular edema identified more than 24 months after cataract surgery." | 9.09 | Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction. ( Bressler, NM; Bressler, SB; Schachat, AP; Weisz, JM, 1999) |
| "This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain." | 7.73 | Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005) |
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 7.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| "To evaluate whether ketorolac ophthalmic drops prescribed four times a day can be associated with improved visual acuity and prompt resolution of edema for patients with pseudophakic cystoid macular edema identified more than 24 months after cataract surgery." | 5.09 | Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction. ( Bressler, NM; Bressler, SB; Schachat, AP; Weisz, JM, 1999) |
| "This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain." | 3.73 | Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005) |
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 3.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| " Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic." | 2.82 | Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. ( Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC, 2022) |
| " Pain levels were also recorded at 15 and 30 minutes after the initial IN dosing (before endodontic treatment); 30 minutes after completion of endodontic treatment; and 4, 8, and 12 hours after the initial IN spray." | 2.76 | Sniffing out endodontic pain: use of an intranasal analgesic in a randomized clinical trial. ( Bowles, WR; Eggleston, GW; Johnson, N; Lunos, S; Turner, CL; Wiedmann, TS, 2011) |
| "Indomethacin was used orally and was found to be ineffective for chronic CMO in one trial." | 2.48 | Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. ( Bunce, C; Crosby-Nwaobi, R; Sivaprasad, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ziesenitz, VC | 1 |
| Welzel, T | 1 |
| van Dyk, M | 1 |
| Saur, P | 1 |
| Gorenflo, M | 1 |
| van den Anker, JN | 1 |
| Seeger, DR | 1 |
| Golovko, SA | 1 |
| Grove, BD | 1 |
| Golovko, MY | 1 |
| Scarlett, JM | 1 |
| Zhu, X | 1 |
| Enriori, PJ | 1 |
| Bowe, DD | 1 |
| Batra, AK | 1 |
| Levasseur, PR | 1 |
| Grant, WF | 1 |
| Meguid, MM | 1 |
| Cowley, MA | 1 |
| Marks, DL | 1 |
| Turner, CL | 1 |
| Eggleston, GW | 1 |
| Lunos, S | 1 |
| Johnson, N | 1 |
| Wiedmann, TS | 1 |
| Bowles, WR | 1 |
| Sivaprasad, S | 1 |
| Bunce, C | 1 |
| Crosby-Nwaobi, R | 1 |
| Good, P | 1 |
| Tullio, F | 1 |
| Jackson, K | 1 |
| Goodchild, C | 1 |
| Ashby, M | 1 |
| Eipe, N | 1 |
| Kay, J | 1 |
| Miller, LJ | 1 |
| Kramer, MA | 1 |
| Weisz, JM | 1 |
| Bressler, NM | 1 |
| Bressler, SB | 1 |
| Schachat, AP | 1 |
| Saberski, LR | 1 |
| Ahmad, M | 1 |
| Munir, MA | 1 |
| Brull, SJ | 1 |
2 reviews available for ketorolac and Chronic Disease
| Article | Year |
|---|---|
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; C | 2022 |
Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Chronic Disease; Fenopr | 2012 |
2 trials available for ketorolac and Chronic Disease
| Article | Year |
|---|---|
Sniffing out endodontic pain: use of an intranasal analgesic in a randomized clinical trial.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chroni | 2011 |
Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Chronic Disea | 1999 |
6 other studies available for ketorolac and Chronic Disease
| Article | Year |
|---|---|
Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia.
Topics: Angiogenesis Inhibitors; Animals; Chronic Disease; Cyclooxygenase Inhibitors; Dose-Response Relation | 2021 |
Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
Topics: Agouti-Related Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arcuate Nucleus of Hypotha | 2008 |
Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age | 2005 |
Spontaneously breathing technique for opioid tolerance.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhalation; Anti-Inflammatory | 2008 |
Pain management with intravenous ketorolac.
Topics: Adenocarcinoma; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Neoplasms; Chr | 1993 |
Identification of a new therapeutic approach for iliac crest donor site chronic pain: a case report.
Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bone Transplantation; Bupivacaine; Chro | 1999 |