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ketorolac and Chronic Disease

ketorolac has been researched along with Chronic Disease in 10 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"To evaluate whether ketorolac ophthalmic drops prescribed four times a day can be associated with improved visual acuity and prompt resolution of edema for patients with pseudophakic cystoid macular edema identified more than 24 months after cataract surgery."9.09Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction. ( Bressler, NM; Bressler, SB; Schachat, AP; Weisz, JM, 1999)
"This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain."7.73Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005)
"To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain."7.68Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993)
"To evaluate whether ketorolac ophthalmic drops prescribed four times a day can be associated with improved visual acuity and prompt resolution of edema for patients with pseudophakic cystoid macular edema identified more than 24 months after cataract surgery."5.09Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction. ( Bressler, NM; Bressler, SB; Schachat, AP; Weisz, JM, 1999)
"This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain."3.73Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005)
"To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain."3.68Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993)
" Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic."2.82Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. ( Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC, 2022)
" Pain levels were also recorded at 15 and 30 minutes after the initial IN dosing (before endodontic treatment); 30 minutes after completion of endodontic treatment; and 4, 8, and 12 hours after the initial IN spray."2.76Sniffing out endodontic pain: use of an intranasal analgesic in a randomized clinical trial. ( Bowles, WR; Eggleston, GW; Johnson, N; Lunos, S; Turner, CL; Wiedmann, TS, 2011)
"Indomethacin was used orally and was found to be ineffective for chronic CMO in one trial."2.48Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. ( Bunce, C; Crosby-Nwaobi, R; Sivaprasad, S, 2012)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's3 (30.00)29.6817
2010's2 (20.00)24.3611
2020's2 (20.00)2.80

Authors

AuthorsStudies
Ziesenitz, VC1
Welzel, T1
van Dyk, M1
Saur, P1
Gorenflo, M1
van den Anker, JN1
Seeger, DR1
Golovko, SA1
Grove, BD1
Golovko, MY1
Scarlett, JM1
Zhu, X1
Enriori, PJ1
Bowe, DD1
Batra, AK1
Levasseur, PR1
Grant, WF1
Meguid, MM1
Cowley, MA1
Marks, DL1
Turner, CL1
Eggleston, GW1
Lunos, S1
Johnson, N1
Wiedmann, TS1
Bowles, WR1
Sivaprasad, S1
Bunce, C1
Crosby-Nwaobi, R1
Good, P1
Tullio, F1
Jackson, K1
Goodchild, C1
Ashby, M1
Eipe, N1
Kay, J1
Miller, LJ1
Kramer, MA1
Weisz, JM1
Bressler, NM1
Bressler, SB1
Schachat, AP1
Saberski, LR1
Ahmad, M1
Munir, MA1
Brull, SJ1

Reviews

2 reviews available for ketorolac and Chronic Disease

ArticleYear
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; C

2022
Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery.
    The Cochrane database of systematic reviews, 2012, Feb-15, Issue:2

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Chronic Disease; Fenopr

2012

Trials

2 trials available for ketorolac and Chronic Disease

ArticleYear
Sniffing out endodontic pain: use of an intranasal analgesic in a randomized clinical trial.
    Journal of endodontics, 2011, Volume: 37, Issue:4

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chroni

2011
Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction.
    Ophthalmology, 1999, Volume: 106, Issue:9

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Chronic Disea

1999

Other Studies

6 other studies available for ketorolac and Chronic Disease

ArticleYear
Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia.
    Journal of neurochemistry, 2021, Volume: 158, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Chronic Disease; Cyclooxygenase Inhibitors; Dose-Response Relation

2021
Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
    Endocrinology, 2008, Volume: 149, Issue:10

    Topics: Agouti-Related Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arcuate Nucleus of Hypotha

2008
Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain.
    Internal medicine journal, 2005, Volume: 35, Issue:1

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age

2005
Spontaneously breathing technique for opioid tolerance.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhalation; Anti-Inflammatory

2008
Pain management with intravenous ketorolac.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:3

    Topics: Adenocarcinoma; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Neoplasms; Chr

1993
Identification of a new therapeutic approach for iliac crest donor site chronic pain: a case report.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:6

    Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bone Transplantation; Bupivacaine; Chro

1999