ketorolac has been researched along with Cancer of Prostate in 5 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration." | 9.16 | Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012) |
| "Lidocaine-prilocaine cream was most effective on probe-related pain, whereas lidocaine-ketorolac gel was most effective on sampling-related pain." | 5.17 | Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2013) |
| "What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration." | 5.16 | Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012) |
| "The primary outcome was a reduction in postoperative pain as assessed by a visual analogue scale (VAS)." | 2.78 | Intravesical ropivacaine as a novel means of analgesia post-robot-assisted radical prostatectomy: a randomized, double-blind, placebo-controlled trial. ( Fuller, A; Martin, PR; Nott, L; Pautler, SE; Vanderhaeghe, L, 2013) |
| "Minimal postoperative pain has been reported following robot assisted laparoscopic prostatectomy (RALP) but there have been few comparative studies with RRP." | 2.71 | Robotic assisted laparoscopic radical prostatectomy versus retropubic radical prostatectomy: a prospective assessment of postoperative pain. ( Anderson, LW; Baumgartner, RG; Chang, SS; Cookson, MS; Herrell, SD; Smith, JA; Webster, TM, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cormio, L | 2 |
| Lorusso, F | 2 |
| Selvaggio, O | 2 |
| Perrone, A | 2 |
| Sanguedolce, F | 2 |
| Pagliarulo, V | 2 |
| Bufo, P | 2 |
| Carrieri, G | 2 |
| Fuller, A | 1 |
| Vanderhaeghe, L | 1 |
| Nott, L | 1 |
| Martin, PR | 1 |
| Pautler, SE | 1 |
| Palayoor, ST | 1 |
| Tofilon, PJ | 1 |
| Coleman, CN | 1 |
| Webster, TM | 1 |
| Herrell, SD | 1 |
| Chang, SS | 1 |
| Cookson, MS | 1 |
| Baumgartner, RG | 1 |
| Anderson, LW | 1 |
| Smith, JA | 1 |
4 trials available for ketorolac and Cancer of Prostate
1 other study available for ketorolac and Cancer of Prostate
| Article | Year |
|---|---|
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tu | 2003 |