ketorolac has been researched along with Cancer of Lung in 6 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Focusing on a high-risk group with preoperative inflammation could lead to a clinical trial to test the effect of ketorolac on cancer outcome." | 4.90 | Perspectives in anaesthesia for cancer surgery. ( De Kock, M; Forget, P, 2014) |
| "To investigate the efficacy and safety of whole-course application of dexmedetomidine combined with ketorolac in nonnarcotic postoperative analgesia and its effect on inflammatory response and immune function in thoracoscopic surgery of lung cancer." | 2.94 | Whole-Course Application of Dexmedetomidine Combined with Ketorolac in Nonnarcotic Postoperative Analgesia for Patients with Lung Cancer Undergoing Thoracoscopic Surgery: A Randomized Control Trial. ( Hou, QH; Lin, Y; Lu, XY; Lv, R; Miao, Z; Wang, J; Wen, QP; Wu, P; Zhou, FC, 2020) |
| "The intraoperative use of NSAIDs in breast cancer patients (Centre 1) is associated with a reduced recurrence rate (HR = 0." | 1.39 | Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery. ( Berliere, M; Canon, JL; Coulie, PG; De Kock, M; Forget, P; Kremer, Y; Legrand, C; Machiels, JP; Poncelet, AJ; Stainier, A; Tombal, B, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Miao, Z | 1 |
| Wu, P | 1 |
| Wang, J | 1 |
| Zhou, FC | 1 |
| Lin, Y | 1 |
| Lu, XY | 1 |
| Lv, R | 1 |
| Hou, QH | 1 |
| Wen, QP | 1 |
| Connolly, JG | 1 |
| Scarpa, JR | 1 |
| Gupta, HV | 1 |
| Tan, KS | 1 |
| Mastrogiacomo, B | 1 |
| Dycoco, J | 1 |
| Caso, R | 1 |
| Jones, GD | 1 |
| Sanchez-Vega, F | 1 |
| Adusumilli, PS | 1 |
| Rocco, G | 1 |
| Isbell, JM | 1 |
| Bott, MJ | 1 |
| Irie, T | 1 |
| McCormick, PJ | 1 |
| Fischer, GW | 1 |
| Jones, DR | 1 |
| Mincer, JS | 1 |
| Forget, P | 2 |
| Machiels, JP | 1 |
| Coulie, PG | 1 |
| Berliere, M | 1 |
| Poncelet, AJ | 1 |
| Tombal, B | 1 |
| Stainier, A | 1 |
| Legrand, C | 1 |
| Canon, JL | 1 |
| Kremer, Y | 1 |
| De Kock, M | 2 |
| Boussofara, M | 1 |
| Mtaallah, MH | 1 |
| Bracco, D | 1 |
| Sellam, MR | 1 |
| Raucoles, M | 1 |
| Blackwell, N | 1 |
| Bangham, L | 1 |
| Hughes, M | 1 |
| Melzack, D | 1 |
| Trotman, I | 1 |
1 review available for ketorolac and Cancer of Lung
| Article | Year |
|---|---|
Perspectives in anaesthesia for cancer surgery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Breast Neoplasms; Clinical Trials as Topic; Fem | 2014 |
2 trials available for ketorolac and Cancer of Lung
| Article | Year |
|---|---|
Whole-Course Application of Dexmedetomidine Combined with Ketorolac in Nonnarcotic Postoperative Analgesia for Patients with Lung Cancer Undergoing Thoracoscopic Surgery: A Randomized Control Trial.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Dexmedetomidine; Double-Blind Method | 2020 |
Co-analgesic effect of ketorolac after thoracic surgery.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Lung Diseases; Lung | 2006 |
3 other studies available for ketorolac and Cancer of Lung
| Article | Year |
|---|---|
Intraoperative ketorolac may interact with patient-specific tumour genomics to modify recurrence risk in lung adenocarcinoma: an exploratory analysis.
Topics: Adenocarcinoma of Lung; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Gene Regulatory | 2021 |
Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Carcinoma, Non-Small-Cell | 2013 |
Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; | 1993 |